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Dose finding studies for therapies with late‐onset toxicities: A comparison study of designs

An objective of phase I dose‐finding trials is to find the maximum tolerated dose; the dose with a particular risk of toxicity. Frequently, this risk is assessed across the first cycle of therapy. However, in oncology, a course of treatment frequently consists of multiple cycles of therapy. In many...

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Detalles Bibliográficos
Autores principales: Barnett, Helen, Boix, Oliver, Kontos, Dimitris, Jaki, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092569/
https://www.ncbi.nlm.nih.gov/pubmed/36250912
http://dx.doi.org/10.1002/sim.9593

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