TRPM8 indicates poor prognosis in colorectal cancer patients and its pharmacological targeting reduces tumour growth in mice by inhibiting Wnt/β‐catenin signalling

BACKGROUND AND PURPOSE: Transient receptor potential melastatin type‐8 (TRPM8) is a cold‐sensitive cation channel protein belonging to the TRP superfamily of ion channels. Here, we reveal the molecular mechanism of TRPM8 and its clinical relevance in colorectal cancer (CRC). EXPERIMENTAL APPROACH: T...

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Detalles Bibliográficos
Autores principales: Pagano, Ester, Romano, Barbara, Cicia, Donatella, Iannotti, Fabio A., Venneri, Tommaso, Lucariello, Giuseppe, Nanì, Maria Francesca, Cattaneo, Fabio, De Cicco, Paola, D'Armiento, Maria, De Luca, Marcello, Lionetti, Ruggiero, Lama, Stefania, Stiuso, Paola, Zoppoli, Pietro, Falco, Geppino, Marchianò, Silvia, Fiorucci, Stefano, Capasso, Raffaele, Di Marzo, Vincenzo, Borrelli, Francesca, Izzo, Angelo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092658/
https://www.ncbi.nlm.nih.gov/pubmed/36168728
http://dx.doi.org/10.1111/bph.15960

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