Chemical-proteomics Identify Peroxiredoxin-1 as an Actionable Target in Triple-negative Breast Cancer

Triple-negative breast cancer (TNBC) is difficult to treat; therefore, the development of drugs directed against its oncogenic vulnerabilities is a desirable goal. Herein, we report the antitumor effects of CM728, a novel quinone-fused oxazepine, against this malignancy. CM728 potently inhibited TNB...

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Detalles Bibliográficos
Autores principales: Spínola-Lasso, Elena, Montero, Juan Carlos, Jiménez-Monzón, Roberto, Estévez, Francisco, Quintana, José, Guerra, Borja, Elokely, Khaled M., León, Francisco, del Rosario, Henoc, Fernández-Pérez, Leandro, López, Manuel Rodríguez, Díaz-Chico, Bonifacio Nicolás, McNaughton-Smith, Grant, Pandiella, Atanasio, Díaz-Chico, Juan Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092761/
https://www.ncbi.nlm.nih.gov/pubmed/37063429
http://dx.doi.org/10.7150/ijbs.78554

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