Stem cell-derived exosome versus stem cell therapy

Stem cell therapies are being explored for the treatment of various diseases, including haematological disease, immune disease, neurodegenerative disease, and tissue injuries. Alternatively, stem cell-derived exosomes may provide similar clinical benefits without the biosafety concerns associated wi...

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Detalles Bibliográficos
Autores principales: Zhang, Kaiyue, Cheng, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092910/
https://www.ncbi.nlm.nih.gov/pubmed/37359776
http://dx.doi.org/10.1038/s44222-023-00064-2
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author Zhang, Kaiyue
Cheng, Ke
author_facet Zhang, Kaiyue
Cheng, Ke
author_sort Zhang, Kaiyue
collection PubMed
description Stem cell therapies are being explored for the treatment of various diseases, including haematological disease, immune disease, neurodegenerative disease, and tissue injuries. Alternatively, stem cell-derived exosomes may provide similar clinical benefits without the biosafety concerns associated with the transplantation of living cells. However, large-scale manufacturing and purification, batch-to-batch variation, and analysis of the complex cargos of exosomes will need to be addressed to enable their clinical translation.
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spelling pubmed-100929102023-04-14 Stem cell-derived exosome versus stem cell therapy Zhang, Kaiyue Cheng, Ke Nat Rev Bioeng Comment Stem cell therapies are being explored for the treatment of various diseases, including haematological disease, immune disease, neurodegenerative disease, and tissue injuries. Alternatively, stem cell-derived exosomes may provide similar clinical benefits without the biosafety concerns associated with the transplantation of living cells. However, large-scale manufacturing and purification, batch-to-batch variation, and analysis of the complex cargos of exosomes will need to be addressed to enable their clinical translation. Nature Publishing Group UK 2023-04-12 /pmc/articles/PMC10092910/ /pubmed/37359776 http://dx.doi.org/10.1038/s44222-023-00064-2 Text en © Springer Nature Limited 2023 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Comment
Zhang, Kaiyue
Cheng, Ke
Stem cell-derived exosome versus stem cell therapy
title Stem cell-derived exosome versus stem cell therapy
title_full Stem cell-derived exosome versus stem cell therapy
title_fullStr Stem cell-derived exosome versus stem cell therapy
title_full_unstemmed Stem cell-derived exosome versus stem cell therapy
title_short Stem cell-derived exosome versus stem cell therapy
title_sort stem cell-derived exosome versus stem cell therapy
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092910/
https://www.ncbi.nlm.nih.gov/pubmed/37359776
http://dx.doi.org/10.1038/s44222-023-00064-2
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