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Fluorescence and Intraoperative Ultrasound as Surgical Adjuncts for Brain Metastases Resection: What Do We Know? A Systematic Review of the Literature
SIMPLE SUMMARY: The purpose of this review stems from the need, based on the incidence of brain metastases, to investigate the roles of some intraoperative adjuncts. Surgery still plays a central role in the treatment of this disease for an optimal local control of the disease. It is therefore essen...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092992/ https://www.ncbi.nlm.nih.gov/pubmed/37046709 http://dx.doi.org/10.3390/cancers15072047 |
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author | Di Cristofori, Andrea Carone, Giovanni Rocca, Alessandra Rui, Chiara Benedetta Trezza, Andrea Carrabba, Giorgio Giussani, Carlo |
author_facet | Di Cristofori, Andrea Carone, Giovanni Rocca, Alessandra Rui, Chiara Benedetta Trezza, Andrea Carrabba, Giorgio Giussani, Carlo |
author_sort | Di Cristofori, Andrea |
collection | PubMed |
description | SIMPLE SUMMARY: The purpose of this review stems from the need, based on the incidence of brain metastases, to investigate the roles of some intraoperative adjuncts. Surgery still plays a central role in the treatment of this disease for an optimal local control of the disease. It is therefore essential to know all the tools that can help to achieve this goal safely and with maximum results. To this end, intraoperative tumour enhancing methods and intraoperative visualisation systems were examined. ABSTRACT: (1) Background: brain metastases (BMs) are the most common neoplasm of the central nervous system; despite the high incidence of this type of tumour, to date there is no universal consensus on the most effective treatment in patients with BMs, even if surgery still plays a primary role. Despite this, the adjunct systems that help to reach the GTR, which are well structured for other tumour forms such as ultrasound and fluorescence systems, are not yet well employed and standardised in surgical practice. The aim of this review is to provide a picture of the current state-of-art of the roles of iOUS and intraoperative fluorescence to better understand their potential roles as surgical tools. (2) Methods: to reach this goal, the PubMed database was searched using the following string as the keyword: (((Brain cerebral metastasis [MeSH Major Topic])OR (brain metastasis, [MeSH Major Topic])) AND ((5-ala, [MeSH Terms]) OR (Aminolevulinicacid [All fields]) OR (fluorescein, [MeSH Terms]) OR (contrast enhanced ultrasound [MeSH Terms])OR ((intraoperative ultrasound. [MeSH Terms]))) AND (english [Filter]) AND ((english [Filter]) AND (2010:2022 [pdat])) AND (english [Filter]). (3) Results: from our research, a total of 661 articles emerged; of these, 57 were selected. 21 of these included BMs generically as a secondary class for comparisons with gliomas, without going deeply into specific details. Therefore, for our purposes, 36 articles were considered. (4) Conclusions: with regard to BMs treatment and their surgical adjuncts, there is still much to be explored. This is mainly related to the heterogeneity of patients, the primary tumour histology and the extent of systemic disease; regardless, surgery plays a paramount role in obtaining a local disease control, and more standardised surgical protocols need to be made, with the aim of optimizing the use of the available surgical adjuncts and in order to increase the rate of GTR. |
format | Online Article Text |
id | pubmed-10092992 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100929922023-04-13 Fluorescence and Intraoperative Ultrasound as Surgical Adjuncts for Brain Metastases Resection: What Do We Know? A Systematic Review of the Literature Di Cristofori, Andrea Carone, Giovanni Rocca, Alessandra Rui, Chiara Benedetta Trezza, Andrea Carrabba, Giorgio Giussani, Carlo Cancers (Basel) Systematic Review SIMPLE SUMMARY: The purpose of this review stems from the need, based on the incidence of brain metastases, to investigate the roles of some intraoperative adjuncts. Surgery still plays a central role in the treatment of this disease for an optimal local control of the disease. It is therefore essential to know all the tools that can help to achieve this goal safely and with maximum results. To this end, intraoperative tumour enhancing methods and intraoperative visualisation systems were examined. ABSTRACT: (1) Background: brain metastases (BMs) are the most common neoplasm of the central nervous system; despite the high incidence of this type of tumour, to date there is no universal consensus on the most effective treatment in patients with BMs, even if surgery still plays a primary role. Despite this, the adjunct systems that help to reach the GTR, which are well structured for other tumour forms such as ultrasound and fluorescence systems, are not yet well employed and standardised in surgical practice. The aim of this review is to provide a picture of the current state-of-art of the roles of iOUS and intraoperative fluorescence to better understand their potential roles as surgical tools. (2) Methods: to reach this goal, the PubMed database was searched using the following string as the keyword: (((Brain cerebral metastasis [MeSH Major Topic])OR (brain metastasis, [MeSH Major Topic])) AND ((5-ala, [MeSH Terms]) OR (Aminolevulinicacid [All fields]) OR (fluorescein, [MeSH Terms]) OR (contrast enhanced ultrasound [MeSH Terms])OR ((intraoperative ultrasound. [MeSH Terms]))) AND (english [Filter]) AND ((english [Filter]) AND (2010:2022 [pdat])) AND (english [Filter]). (3) Results: from our research, a total of 661 articles emerged; of these, 57 were selected. 21 of these included BMs generically as a secondary class for comparisons with gliomas, without going deeply into specific details. Therefore, for our purposes, 36 articles were considered. (4) Conclusions: with regard to BMs treatment and their surgical adjuncts, there is still much to be explored. This is mainly related to the heterogeneity of patients, the primary tumour histology and the extent of systemic disease; regardless, surgery plays a paramount role in obtaining a local disease control, and more standardised surgical protocols need to be made, with the aim of optimizing the use of the available surgical adjuncts and in order to increase the rate of GTR. MDPI 2023-03-29 /pmc/articles/PMC10092992/ /pubmed/37046709 http://dx.doi.org/10.3390/cancers15072047 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Di Cristofori, Andrea Carone, Giovanni Rocca, Alessandra Rui, Chiara Benedetta Trezza, Andrea Carrabba, Giorgio Giussani, Carlo Fluorescence and Intraoperative Ultrasound as Surgical Adjuncts for Brain Metastases Resection: What Do We Know? A Systematic Review of the Literature |
title | Fluorescence and Intraoperative Ultrasound as Surgical Adjuncts for Brain Metastases Resection: What Do We Know? A Systematic Review of the Literature |
title_full | Fluorescence and Intraoperative Ultrasound as Surgical Adjuncts for Brain Metastases Resection: What Do We Know? A Systematic Review of the Literature |
title_fullStr | Fluorescence and Intraoperative Ultrasound as Surgical Adjuncts for Brain Metastases Resection: What Do We Know? A Systematic Review of the Literature |
title_full_unstemmed | Fluorescence and Intraoperative Ultrasound as Surgical Adjuncts for Brain Metastases Resection: What Do We Know? A Systematic Review of the Literature |
title_short | Fluorescence and Intraoperative Ultrasound as Surgical Adjuncts for Brain Metastases Resection: What Do We Know? A Systematic Review of the Literature |
title_sort | fluorescence and intraoperative ultrasound as surgical adjuncts for brain metastases resection: what do we know? a systematic review of the literature |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092992/ https://www.ncbi.nlm.nih.gov/pubmed/37046709 http://dx.doi.org/10.3390/cancers15072047 |
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