Cargando…

Cracking the Code of Neuronal Cell Fate

Transcriptional regulation is fundamental to most biological processes and reverse-engineering programs can be used to decipher the underlying programs. In this review, we describe how genomics is offering a systems biology-based perspective of the intricate and temporally coordinated transcriptiona...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morello, Giovanna, La Cognata, Valentina, Guarnaccia, Maria, D’Agata, Velia, Cavallaro, Sebastiano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093029/ https://www.ncbi.nlm.nih.gov/pubmed/37048129 http://dx.doi.org/10.3390/cells12071057

Ejemplares similares

Transcriptional Profiles of Cell Fate Transitions Reveal Early Drivers of Neuronal Apoptosis and Survival
por: Morello, Giovanna, et al.
Publicado: (2021)

Copy number variability in Parkinson’s disease: assembling the puzzle through a systems biology approach
por: La Cognata, Valentina, et al.
Publicado: (2016)

Copy Number Variations in Amyotrophic Lateral Sclerosis: Piecing the Mosaic Tiles Together through a Systems Biology Approach
por: Morello, Giovanna, et al.
Publicado: (2017)

CXCR2 Is Deregulated in ALS Spinal Cord and Its Activation Triggers Apoptosis in Motor Neuron-Like Cells Overexpressing hSOD1-G93A
por: La Cognata, Valentina, et al.
Publicado: (2023)

The ε-Isozyme of Protein Kinase C (PKCε) Is Impaired in ALS Motor Cortex and Its Pulse Activation by Bryostatin-1 Produces Long Term Survival in Degenerating SOD1-G93A Motor Neuron-like Cells
por: La Cognata, Valentina, et al.
Publicado: (2023)

Splicing: is there an alternative contribution to Parkinson’s disease?
por: La Cognata, Valentina, et al.
Publicado: (2015)

A customized high-resolution array-comparative genomic hybridization to explore copy number variations in Parkinson’s disease
por: La Cognata, Valentina, et al.
Publicado: (2016)

Alternative Splicing Generates Different Parkin Protein Isoforms: Evidences in Human, Rat, and Mouse Brain
por: Scuderi, Soraya, et al.
Publicado: (2014)

Increasing the Coding Potential of Genomes Through Alternative Splicing: The Case of PARK2 Gene
por: Cognata, Valentina La, et al.
Publicado: (2014)

Design and Validation of a Custom NGS Panel Targeting a Set of Lysosomal Storage Diseases Candidate for NBS Applications
por: La Cognata, Valentina, et al.
Publicado: (2021)

Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases
por: Gentile, Giulia, et al.
Publicado: (2022)

Highlights on Genomics Applications for Lysosomal Storage Diseases
por: La Cognata, Valentina, et al.
Publicado: (2020)

Omics Data and Their Integrative Analysis to Support Stratified Medicine in Neurodegenerative Diseases
por: La Cognata, Valentina, et al.
Publicado: (2021)

NeuroArray, A Custom CGH Microarray to Decipher Copy Number Variants in Alzheimer’s Disease
por: Cuccaro, Denis, et al.
Publicado: (2018)

Integrative multi-omic analysis identifies new drivers and pathways in molecularly distinct subtypes of ALS
por: Morello, Giovanna, et al.
Publicado: (2019)

Transcriptomic Analysis in the Hippocampus and Retina of Tg2576 AD Mice Reveals Defective Mitochondrial Oxidative Phosphorylation and Recovery by Tau 12A12mAb Treatment
por: Morello, Giovanna, et al.
Publicado: (2023)

A Diagnostic Gene-Expression Signature in Fibroblasts of Amyotrophic Lateral Sclerosis
por: Morello, Giovanna, et al.
Publicado: (2023)

Development of a Pharmacogenetic Lab-on-Chip Assay Based on the In-Check Technology to Screen for Genetic Variations Associated to Adverse Drug Reactions to Common Chemotherapeutic Agents
por: Iemmolo, Rosario, et al.
Publicado: (2020)

From Multi-Omics Approaches to Precision Medicine in Amyotrophic Lateral Sclerosis
por: Morello, Giovanna, et al.
Publicado: (2020)

Selection and Prioritization of Candidate Drug Targets for Amyotrophic Lateral Sclerosis Through a Meta-Analysis Approach
por: Morello, Giovanna, et al.
Publicado: (2017)

iPSCs: A Preclinical Drug Research Tool for Neurological Disorders
por: Bonaventura, Gabriele, et al.
Publicado: (2021)

Differential Vulnerability of Oculomotor Versus Hypoglossal Nucleus During ALS: Involvement of PACAP
por: Maugeri, Grazia, et al.
Publicado: (2020)

Detection of Single-Nucleotide and Copy Number Defects Underlying Hyperphenylalaninemia by Next-Generation Sequencing
por: Tendi, Elisabetta Anna, et al.
Publicado: (2023)

NeuroArray: A Customized aCGH for the Analysis of Copy Number Variations in Neurological Disorders
por: La Cognata, Valentina, et al.
Publicado: (2018)

Cracking the code of neuronal apoptosis and survival
por: Cavallaro, S
Publicado: (2015)

Detection of Structural Variants by NGS: Revealing Missing Alleles in Lysosomal Storage Diseases
por: La Cognata, Valentina, et al.
Publicado: (2022)

The Utility of Genomic Testing for Hyperphenylalaninemia
por: Tendi, Elisabetta Anna, et al.
Publicado: (2022)

A Comprehensive, Targeted NGS Approach to Assessing Molecular Diagnosis of Lysosomal Storage Diseases
por: La Cognata, Valentina, et al.
Publicado: (2021)

PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression
por: Maugeri, Grazia, et al.
Publicado: (2016)

A Targeted Next-Generation Sequencing Panel to Genotype Gliomas
por: Guarnaccia, Maria, et al.
Publicado: (2022)

PACAP Modulates the Autophagy Process in an In Vitro Model of Amyotrophic Lateral Sclerosis
por: D’Amico, Agata Grazia, et al.
Publicado: (2020)

Splicing Players Are Differently Expressed in Sporadic Amyotrophic Lateral Sclerosis Molecular Clusters and Brain Regions
por: La Cognata, Valentina, et al.
Publicado: (2020)

Effects of PACAP on Schwann Cells: Focus on Nerve Injury
por: Maugeri, Grazia, et al.
Publicado: (2020)

Effects of Physical Activity on Amyotrophic Lateral Sclerosis
por: Maugeri, Grazia, et al.
Publicado: (2020)

Cracking the Monoubiquitin Code of Genetic Diseases
por: Sewduth, Raj Nayan, et al.
Publicado: (2020)

Activity-Dependent Neuroprotective Protein (ADNP): An Overview of Its Role in the Eye
por: Maugeri, Grazia, et al.
Publicado: (2022)

The Practice of Physical Activity on Psychological, Mental, Physical, and Social Wellbeing for Breast-Cancer Survivors: An Umbrella Review
por: Zanghì, Marta, et al.
Publicado: (2022)

Genomic Portrait of a Sporadic Amyotrophic Lateral Sclerosis Case in a Large Spinocerebellar Ataxia Type 1 Family
por: Morello, Giovanna, et al.
Publicado: (2020)

Role of exercise in the brain: focus on oligodendrocytes and remyelination
por: Maugeri, Grazia, et al.
Publicado: (2023)

Transcriptional landscapes at the intersection of neuronal apoptosis and substance P-induced survival: exploring pathways and drug targets
por: Paparone, S, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_tl7m0h14b10115rb4atdrco6cv