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Effect of Systemic Prednisone Treatment on Changes of Inflammation Markers in Chronic Rhinosinusitis

(1) Objective: We aimed to evaluate the effect of treatment with prednisone on nasal and systemic periostin and eotaxin expression, IgE in plasma and eosinophils in tissue. (2) Methods: We compared the values of nasal and systemic periostin, eotaxin, IgE and eosinophils in tissue in patients treated...

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Autores principales: Wierzchowska, Malgorzata, Kalińczak-Górna, Paulina, Zwolińska, Magdalena, Ligmanowska, Joanna, Durślewicz, Justyna, Zwierz, Aleksander, Malinowski, Bartosz, Wiciński, Michał, Burduk, Paweł
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093034/
https://www.ncbi.nlm.nih.gov/pubmed/37046572
http://dx.doi.org/10.3390/diagnostics13071354
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author Wierzchowska, Malgorzata
Kalińczak-Górna, Paulina
Zwolińska, Magdalena
Ligmanowska, Joanna
Durślewicz, Justyna
Zwierz, Aleksander
Malinowski, Bartosz
Wiciński, Michał
Burduk, Paweł
author_facet Wierzchowska, Malgorzata
Kalińczak-Górna, Paulina
Zwolińska, Magdalena
Ligmanowska, Joanna
Durślewicz, Justyna
Zwierz, Aleksander
Malinowski, Bartosz
Wiciński, Michał
Burduk, Paweł
author_sort Wierzchowska, Malgorzata
collection PubMed
description (1) Objective: We aimed to evaluate the effect of treatment with prednisone on nasal and systemic periostin and eotaxin expression, IgE in plasma and eosinophils in tissue. (2) Methods: We compared the values of nasal and systemic periostin, eotaxin, IgE and eosinophils in tissue in patients treated with only nasal steroids before FESS, group 1, with those treated with an oral steroid–prednisone, group 2. (3) Results: A statistically significant decrease in the level of periostin, eotaxin and IgE in plasma was achieved in patients treated with prednisone one week before and after surgery (in sequence: p < 0.0476, p < 0.0006, p < 0.0031). In patients treated with steroids, we also observed a lower level of periostin in the epithelium (p < 0.044), eotaxin in the stroma (p limit value < 0.075) and eosinophils (p < 0.031) in the tissues collected during the operation. (4) Conclusions: Systemic steroid treatment with prednisone distinctly decreases periostin, eotaxin and IgE expression in plasma. We also observed a lower level of periostin in the epithelium, eotaxin in the stroma and eosinophils in the tissues. We need more attempts to find inflammatory markers associated with chronic rhinosinusitis. Identifying drugs that decrease inflammatory parameters would allow for more targeted therapy.
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spelling pubmed-100930342023-04-13 Effect of Systemic Prednisone Treatment on Changes of Inflammation Markers in Chronic Rhinosinusitis Wierzchowska, Malgorzata Kalińczak-Górna, Paulina Zwolińska, Magdalena Ligmanowska, Joanna Durślewicz, Justyna Zwierz, Aleksander Malinowski, Bartosz Wiciński, Michał Burduk, Paweł Diagnostics (Basel) Article (1) Objective: We aimed to evaluate the effect of treatment with prednisone on nasal and systemic periostin and eotaxin expression, IgE in plasma and eosinophils in tissue. (2) Methods: We compared the values of nasal and systemic periostin, eotaxin, IgE and eosinophils in tissue in patients treated with only nasal steroids before FESS, group 1, with those treated with an oral steroid–prednisone, group 2. (3) Results: A statistically significant decrease in the level of periostin, eotaxin and IgE in plasma was achieved in patients treated with prednisone one week before and after surgery (in sequence: p < 0.0476, p < 0.0006, p < 0.0031). In patients treated with steroids, we also observed a lower level of periostin in the epithelium (p < 0.044), eotaxin in the stroma (p limit value < 0.075) and eosinophils (p < 0.031) in the tissues collected during the operation. (4) Conclusions: Systemic steroid treatment with prednisone distinctly decreases periostin, eotaxin and IgE expression in plasma. We also observed a lower level of periostin in the epithelium, eotaxin in the stroma and eosinophils in the tissues. We need more attempts to find inflammatory markers associated with chronic rhinosinusitis. Identifying drugs that decrease inflammatory parameters would allow for more targeted therapy. MDPI 2023-04-05 /pmc/articles/PMC10093034/ /pubmed/37046572 http://dx.doi.org/10.3390/diagnostics13071354 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wierzchowska, Malgorzata
Kalińczak-Górna, Paulina
Zwolińska, Magdalena
Ligmanowska, Joanna
Durślewicz, Justyna
Zwierz, Aleksander
Malinowski, Bartosz
Wiciński, Michał
Burduk, Paweł
Effect of Systemic Prednisone Treatment on Changes of Inflammation Markers in Chronic Rhinosinusitis
title Effect of Systemic Prednisone Treatment on Changes of Inflammation Markers in Chronic Rhinosinusitis
title_full Effect of Systemic Prednisone Treatment on Changes of Inflammation Markers in Chronic Rhinosinusitis
title_fullStr Effect of Systemic Prednisone Treatment on Changes of Inflammation Markers in Chronic Rhinosinusitis
title_full_unstemmed Effect of Systemic Prednisone Treatment on Changes of Inflammation Markers in Chronic Rhinosinusitis
title_short Effect of Systemic Prednisone Treatment on Changes of Inflammation Markers in Chronic Rhinosinusitis
title_sort effect of systemic prednisone treatment on changes of inflammation markers in chronic rhinosinusitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093034/
https://www.ncbi.nlm.nih.gov/pubmed/37046572
http://dx.doi.org/10.3390/diagnostics13071354
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