Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget’s Disease of Bone

Paget’s Disease of Bone (PDB) is a metabolic bone disease that is characterized by dysregulated osteoclast function leading to focal abnormalities of bone remodeling. It can lead to pain, fracture, and bone deformity. G protein-coupled receptor kinase 3 (GRK3) is an important negative regulator of G...

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Detalles Bibliográficos
Autores principales: Rabjohns, Emily M., Rampersad, Rishi R., Ghosh, Arin, Hurst, Katlyn, Eudy, Amanda M., Brozowski, Jaime M., Lee, Hyun Ho, Ren, Yinshi, Mirando, Anthony, Gladman, Justin, Bowser, Jessica L., Berg, Kathryn, Wani, Sachin, Ralston, Stuart H., Hilton, Matthew J., Tarrant, Teresa K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093054/
https://www.ncbi.nlm.nih.gov/pubmed/37048054
http://dx.doi.org/10.3390/cells12070981

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