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Impaired Mitochondrial Function in T-Lymphocytes as a Result of Exposure to HIV and ART
Mitochondrial dysfunction is a described phenomenon for a number of chronic and infectious diseases. At the same time, the question remains open: is this condition a consequence or a cause of the progression of the disease? In this review, we consider the role of the development of mitochondrial dys...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093108/ https://www.ncbi.nlm.nih.gov/pubmed/37048145 http://dx.doi.org/10.3390/cells12071072 |
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author | Blagov, Alexander V. Sukhorukov, Vasily N. Guo, Shuzhen Zhang, Dongwei Popov, Mikhail A. Orekhov, Alexander N. |
author_facet | Blagov, Alexander V. Sukhorukov, Vasily N. Guo, Shuzhen Zhang, Dongwei Popov, Mikhail A. Orekhov, Alexander N. |
author_sort | Blagov, Alexander V. |
collection | PubMed |
description | Mitochondrial dysfunction is a described phenomenon for a number of chronic and infectious diseases. At the same time, the question remains open: is this condition a consequence or a cause of the progression of the disease? In this review, we consider the role of the development of mitochondrial dysfunction in the progression of HIV (human immunodeficiency viruses) infection and the onset of AIDS (acquired immunodeficiency syndrome), as well as the direct impact of HIV on mitochondria. In addition, we will touch upon such an important issue as the effect of ART (Antiretroviral Therapy) drugs on mitochondria, since ART is currently the only effective way to curb the progression of HIV in infected patients, and because the identification of potential side effects can help to more consciously approach the development of new drugs in the treatment of HIV infection. |
format | Online Article Text |
id | pubmed-10093108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100931082023-04-13 Impaired Mitochondrial Function in T-Lymphocytes as a Result of Exposure to HIV and ART Blagov, Alexander V. Sukhorukov, Vasily N. Guo, Shuzhen Zhang, Dongwei Popov, Mikhail A. Orekhov, Alexander N. Cells Review Mitochondrial dysfunction is a described phenomenon for a number of chronic and infectious diseases. At the same time, the question remains open: is this condition a consequence or a cause of the progression of the disease? In this review, we consider the role of the development of mitochondrial dysfunction in the progression of HIV (human immunodeficiency viruses) infection and the onset of AIDS (acquired immunodeficiency syndrome), as well as the direct impact of HIV on mitochondria. In addition, we will touch upon such an important issue as the effect of ART (Antiretroviral Therapy) drugs on mitochondria, since ART is currently the only effective way to curb the progression of HIV in infected patients, and because the identification of potential side effects can help to more consciously approach the development of new drugs in the treatment of HIV infection. MDPI 2023-04-02 /pmc/articles/PMC10093108/ /pubmed/37048145 http://dx.doi.org/10.3390/cells12071072 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Blagov, Alexander V. Sukhorukov, Vasily N. Guo, Shuzhen Zhang, Dongwei Popov, Mikhail A. Orekhov, Alexander N. Impaired Mitochondrial Function in T-Lymphocytes as a Result of Exposure to HIV and ART |
title | Impaired Mitochondrial Function in T-Lymphocytes as a Result of Exposure to HIV and ART |
title_full | Impaired Mitochondrial Function in T-Lymphocytes as a Result of Exposure to HIV and ART |
title_fullStr | Impaired Mitochondrial Function in T-Lymphocytes as a Result of Exposure to HIV and ART |
title_full_unstemmed | Impaired Mitochondrial Function in T-Lymphocytes as a Result of Exposure to HIV and ART |
title_short | Impaired Mitochondrial Function in T-Lymphocytes as a Result of Exposure to HIV and ART |
title_sort | impaired mitochondrial function in t-lymphocytes as a result of exposure to hiv and art |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093108/ https://www.ncbi.nlm.nih.gov/pubmed/37048145 http://dx.doi.org/10.3390/cells12071072 |
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