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Chondrosarcoma Resistance to Radiation Therapy: Origins and Potential Therapeutic Solutions

SIMPLE SUMMARY: This review article aims in describing the origins of chondrosarcoma radiation-resistance and proposes several potential solutions in order to improve the treatment, in regard with tumor grade and characteristics. ABSTRACT: Chondrosarcoma is a malignant cartilaginous tumor that is pa...

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Autores principales: Gilbert, Antoine, Tudor, Mihaela, Montanari, Juliette, Commenchail, Kevin, Savu, Diana Iulia, Lesueur, Paul, Chevalier, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093143/
https://www.ncbi.nlm.nih.gov/pubmed/37046623
http://dx.doi.org/10.3390/cancers15071962
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author Gilbert, Antoine
Tudor, Mihaela
Montanari, Juliette
Commenchail, Kevin
Savu, Diana Iulia
Lesueur, Paul
Chevalier, François
author_facet Gilbert, Antoine
Tudor, Mihaela
Montanari, Juliette
Commenchail, Kevin
Savu, Diana Iulia
Lesueur, Paul
Chevalier, François
author_sort Gilbert, Antoine
collection PubMed
description SIMPLE SUMMARY: This review article aims in describing the origins of chondrosarcoma radiation-resistance and proposes several potential solutions in order to improve the treatment, in regard with tumor grade and characteristics. ABSTRACT: Chondrosarcoma is a malignant cartilaginous tumor that is particularly chemoresistant and radioresistant to X-rays. The first line of treatment is surgery, though this is almost impossible in some specific locations. Such resistances can be explained by the particular composition of the tumor, which develops within a dense cartilaginous matrix, producing a resistant area where the oxygen tension is very low. This microenvironment forces the cells to adapt and dedifferentiate into cancer stem cells, which are described to be more resistant to conventional treatments. One of the main avenues considered to treat this type of tumor is hadrontherapy, in particular for its ballistic properties but also its greater biological effectiveness against tumor cells. In this review, we describe the different forms of chondrosarcoma resistance and how hadrontherapy, combined with other treatments involving targeted inhibitors, could help to better treat high-grade chondrosarcoma.
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spelling pubmed-100931432023-04-13 Chondrosarcoma Resistance to Radiation Therapy: Origins and Potential Therapeutic Solutions Gilbert, Antoine Tudor, Mihaela Montanari, Juliette Commenchail, Kevin Savu, Diana Iulia Lesueur, Paul Chevalier, François Cancers (Basel) Review SIMPLE SUMMARY: This review article aims in describing the origins of chondrosarcoma radiation-resistance and proposes several potential solutions in order to improve the treatment, in regard with tumor grade and characteristics. ABSTRACT: Chondrosarcoma is a malignant cartilaginous tumor that is particularly chemoresistant and radioresistant to X-rays. The first line of treatment is surgery, though this is almost impossible in some specific locations. Such resistances can be explained by the particular composition of the tumor, which develops within a dense cartilaginous matrix, producing a resistant area where the oxygen tension is very low. This microenvironment forces the cells to adapt and dedifferentiate into cancer stem cells, which are described to be more resistant to conventional treatments. One of the main avenues considered to treat this type of tumor is hadrontherapy, in particular for its ballistic properties but also its greater biological effectiveness against tumor cells. In this review, we describe the different forms of chondrosarcoma resistance and how hadrontherapy, combined with other treatments involving targeted inhibitors, could help to better treat high-grade chondrosarcoma. MDPI 2023-03-24 /pmc/articles/PMC10093143/ /pubmed/37046623 http://dx.doi.org/10.3390/cancers15071962 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gilbert, Antoine
Tudor, Mihaela
Montanari, Juliette
Commenchail, Kevin
Savu, Diana Iulia
Lesueur, Paul
Chevalier, François
Chondrosarcoma Resistance to Radiation Therapy: Origins and Potential Therapeutic Solutions
title Chondrosarcoma Resistance to Radiation Therapy: Origins and Potential Therapeutic Solutions
title_full Chondrosarcoma Resistance to Radiation Therapy: Origins and Potential Therapeutic Solutions
title_fullStr Chondrosarcoma Resistance to Radiation Therapy: Origins and Potential Therapeutic Solutions
title_full_unstemmed Chondrosarcoma Resistance to Radiation Therapy: Origins and Potential Therapeutic Solutions
title_short Chondrosarcoma Resistance to Radiation Therapy: Origins and Potential Therapeutic Solutions
title_sort chondrosarcoma resistance to radiation therapy: origins and potential therapeutic solutions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093143/
https://www.ncbi.nlm.nih.gov/pubmed/37046623
http://dx.doi.org/10.3390/cancers15071962
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