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Chondrosarcoma Resistance to Radiation Therapy: Origins and Potential Therapeutic Solutions
SIMPLE SUMMARY: This review article aims in describing the origins of chondrosarcoma radiation-resistance and proposes several potential solutions in order to improve the treatment, in regard with tumor grade and characteristics. ABSTRACT: Chondrosarcoma is a malignant cartilaginous tumor that is pa...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093143/ https://www.ncbi.nlm.nih.gov/pubmed/37046623 http://dx.doi.org/10.3390/cancers15071962 |
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author | Gilbert, Antoine Tudor, Mihaela Montanari, Juliette Commenchail, Kevin Savu, Diana Iulia Lesueur, Paul Chevalier, François |
author_facet | Gilbert, Antoine Tudor, Mihaela Montanari, Juliette Commenchail, Kevin Savu, Diana Iulia Lesueur, Paul Chevalier, François |
author_sort | Gilbert, Antoine |
collection | PubMed |
description | SIMPLE SUMMARY: This review article aims in describing the origins of chondrosarcoma radiation-resistance and proposes several potential solutions in order to improve the treatment, in regard with tumor grade and characteristics. ABSTRACT: Chondrosarcoma is a malignant cartilaginous tumor that is particularly chemoresistant and radioresistant to X-rays. The first line of treatment is surgery, though this is almost impossible in some specific locations. Such resistances can be explained by the particular composition of the tumor, which develops within a dense cartilaginous matrix, producing a resistant area where the oxygen tension is very low. This microenvironment forces the cells to adapt and dedifferentiate into cancer stem cells, which are described to be more resistant to conventional treatments. One of the main avenues considered to treat this type of tumor is hadrontherapy, in particular for its ballistic properties but also its greater biological effectiveness against tumor cells. In this review, we describe the different forms of chondrosarcoma resistance and how hadrontherapy, combined with other treatments involving targeted inhibitors, could help to better treat high-grade chondrosarcoma. |
format | Online Article Text |
id | pubmed-10093143 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100931432023-04-13 Chondrosarcoma Resistance to Radiation Therapy: Origins and Potential Therapeutic Solutions Gilbert, Antoine Tudor, Mihaela Montanari, Juliette Commenchail, Kevin Savu, Diana Iulia Lesueur, Paul Chevalier, François Cancers (Basel) Review SIMPLE SUMMARY: This review article aims in describing the origins of chondrosarcoma radiation-resistance and proposes several potential solutions in order to improve the treatment, in regard with tumor grade and characteristics. ABSTRACT: Chondrosarcoma is a malignant cartilaginous tumor that is particularly chemoresistant and radioresistant to X-rays. The first line of treatment is surgery, though this is almost impossible in some specific locations. Such resistances can be explained by the particular composition of the tumor, which develops within a dense cartilaginous matrix, producing a resistant area where the oxygen tension is very low. This microenvironment forces the cells to adapt and dedifferentiate into cancer stem cells, which are described to be more resistant to conventional treatments. One of the main avenues considered to treat this type of tumor is hadrontherapy, in particular for its ballistic properties but also its greater biological effectiveness against tumor cells. In this review, we describe the different forms of chondrosarcoma resistance and how hadrontherapy, combined with other treatments involving targeted inhibitors, could help to better treat high-grade chondrosarcoma. MDPI 2023-03-24 /pmc/articles/PMC10093143/ /pubmed/37046623 http://dx.doi.org/10.3390/cancers15071962 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gilbert, Antoine Tudor, Mihaela Montanari, Juliette Commenchail, Kevin Savu, Diana Iulia Lesueur, Paul Chevalier, François Chondrosarcoma Resistance to Radiation Therapy: Origins and Potential Therapeutic Solutions |
title | Chondrosarcoma Resistance to Radiation Therapy: Origins and Potential Therapeutic Solutions |
title_full | Chondrosarcoma Resistance to Radiation Therapy: Origins and Potential Therapeutic Solutions |
title_fullStr | Chondrosarcoma Resistance to Radiation Therapy: Origins and Potential Therapeutic Solutions |
title_full_unstemmed | Chondrosarcoma Resistance to Radiation Therapy: Origins and Potential Therapeutic Solutions |
title_short | Chondrosarcoma Resistance to Radiation Therapy: Origins and Potential Therapeutic Solutions |
title_sort | chondrosarcoma resistance to radiation therapy: origins and potential therapeutic solutions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093143/ https://www.ncbi.nlm.nih.gov/pubmed/37046623 http://dx.doi.org/10.3390/cancers15071962 |
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