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Impaired Intestinal Permeability Assessed by Confocal Laser Endomicroscopy—A New Potential Therapeutic Target in Inflammatory Bowel Disease

Inflammatory bowel diseases (IBD) represent a global phenomenon, with a continuously rising prevalence. The strategies concerning IBD management are progressing from clinical monitorization to a targeted approach, and current therapies strive to reduce microscopic mucosal inflammation and stimulate...

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Autores principales: Chiriac, Stefan, Sfarti, Catalin Victor, Minea, Horia, Stanciu, Carol, Cojocariu, Camelia, Singeap, Ana-Maria, Girleanu, Irina, Cuciureanu, Tudor, Petrea, Oana, Huiban, Laura, Muzica, Cristina Maria, Zenovia, Sebastian, Nastasa, Robert, Stafie, Remus, Rotaru, Adrian, Stratina, Ermina, Trifan, Anca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093200/
https://www.ncbi.nlm.nih.gov/pubmed/37046447
http://dx.doi.org/10.3390/diagnostics13071230
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author Chiriac, Stefan
Sfarti, Catalin Victor
Minea, Horia
Stanciu, Carol
Cojocariu, Camelia
Singeap, Ana-Maria
Girleanu, Irina
Cuciureanu, Tudor
Petrea, Oana
Huiban, Laura
Muzica, Cristina Maria
Zenovia, Sebastian
Nastasa, Robert
Stafie, Remus
Rotaru, Adrian
Stratina, Ermina
Trifan, Anca
author_facet Chiriac, Stefan
Sfarti, Catalin Victor
Minea, Horia
Stanciu, Carol
Cojocariu, Camelia
Singeap, Ana-Maria
Girleanu, Irina
Cuciureanu, Tudor
Petrea, Oana
Huiban, Laura
Muzica, Cristina Maria
Zenovia, Sebastian
Nastasa, Robert
Stafie, Remus
Rotaru, Adrian
Stratina, Ermina
Trifan, Anca
author_sort Chiriac, Stefan
collection PubMed
description Inflammatory bowel diseases (IBD) represent a global phenomenon, with a continuously rising prevalence. The strategies concerning IBD management are progressing from clinical monitorization to a targeted approach, and current therapies strive to reduce microscopic mucosal inflammation and stimulate repair of the epithelial barrier function. Intestinal permeability has recently been receiving increased attention, as evidence suggests that it could be related to disease activity in IBD. However, most investigations do not successfully provide adequate information regarding the morphological integrity of the intestinal barrier. In this review, we discuss the advantages of confocal laser endomicroscopy (CLE), which allows in vivo visualization of histological abnormalities and targeted optical biopsies in the setting of IBD. Additionally, CLE has been used to assess vascular permeability and epithelial barrier function that could correlate with prolonged clinical remission, increased resection-free survival, and lower hospitalization rates. Moreover, the dynamic evaluation of the functional characteristics of the intestinal barrier presents an advantage over the endoscopic examination as it has the potential to select patients at risk of relapses. Along with mucosal healing, histological or transmural remission, the recovery of the intestinal barrier function emerges as a possible target that could be included in the future therapeutic strategies for IBD.
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spelling pubmed-100932002023-04-13 Impaired Intestinal Permeability Assessed by Confocal Laser Endomicroscopy—A New Potential Therapeutic Target in Inflammatory Bowel Disease Chiriac, Stefan Sfarti, Catalin Victor Minea, Horia Stanciu, Carol Cojocariu, Camelia Singeap, Ana-Maria Girleanu, Irina Cuciureanu, Tudor Petrea, Oana Huiban, Laura Muzica, Cristina Maria Zenovia, Sebastian Nastasa, Robert Stafie, Remus Rotaru, Adrian Stratina, Ermina Trifan, Anca Diagnostics (Basel) Review Inflammatory bowel diseases (IBD) represent a global phenomenon, with a continuously rising prevalence. The strategies concerning IBD management are progressing from clinical monitorization to a targeted approach, and current therapies strive to reduce microscopic mucosal inflammation and stimulate repair of the epithelial barrier function. Intestinal permeability has recently been receiving increased attention, as evidence suggests that it could be related to disease activity in IBD. However, most investigations do not successfully provide adequate information regarding the morphological integrity of the intestinal barrier. In this review, we discuss the advantages of confocal laser endomicroscopy (CLE), which allows in vivo visualization of histological abnormalities and targeted optical biopsies in the setting of IBD. Additionally, CLE has been used to assess vascular permeability and epithelial barrier function that could correlate with prolonged clinical remission, increased resection-free survival, and lower hospitalization rates. Moreover, the dynamic evaluation of the functional characteristics of the intestinal barrier presents an advantage over the endoscopic examination as it has the potential to select patients at risk of relapses. Along with mucosal healing, histological or transmural remission, the recovery of the intestinal barrier function emerges as a possible target that could be included in the future therapeutic strategies for IBD. MDPI 2023-03-24 /pmc/articles/PMC10093200/ /pubmed/37046447 http://dx.doi.org/10.3390/diagnostics13071230 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chiriac, Stefan
Sfarti, Catalin Victor
Minea, Horia
Stanciu, Carol
Cojocariu, Camelia
Singeap, Ana-Maria
Girleanu, Irina
Cuciureanu, Tudor
Petrea, Oana
Huiban, Laura
Muzica, Cristina Maria
Zenovia, Sebastian
Nastasa, Robert
Stafie, Remus
Rotaru, Adrian
Stratina, Ermina
Trifan, Anca
Impaired Intestinal Permeability Assessed by Confocal Laser Endomicroscopy—A New Potential Therapeutic Target in Inflammatory Bowel Disease
title Impaired Intestinal Permeability Assessed by Confocal Laser Endomicroscopy—A New Potential Therapeutic Target in Inflammatory Bowel Disease
title_full Impaired Intestinal Permeability Assessed by Confocal Laser Endomicroscopy—A New Potential Therapeutic Target in Inflammatory Bowel Disease
title_fullStr Impaired Intestinal Permeability Assessed by Confocal Laser Endomicroscopy—A New Potential Therapeutic Target in Inflammatory Bowel Disease
title_full_unstemmed Impaired Intestinal Permeability Assessed by Confocal Laser Endomicroscopy—A New Potential Therapeutic Target in Inflammatory Bowel Disease
title_short Impaired Intestinal Permeability Assessed by Confocal Laser Endomicroscopy—A New Potential Therapeutic Target in Inflammatory Bowel Disease
title_sort impaired intestinal permeability assessed by confocal laser endomicroscopy—a new potential therapeutic target in inflammatory bowel disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093200/
https://www.ncbi.nlm.nih.gov/pubmed/37046447
http://dx.doi.org/10.3390/diagnostics13071230
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