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Quantitative MR Neurography in Multifocal Motor Neuropathy and Amyotrophic Lateral Sclerosis
Background: The aim of this study was to assess the phenotype of multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis (ALS) in quantitative MR neurography. Methods: In this prospective study, 22 patients with ALS, 8 patients with MMN, and 10 healthy volunteers were examined with 3T MR...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093201/ https://www.ncbi.nlm.nih.gov/pubmed/37046455 http://dx.doi.org/10.3390/diagnostics13071237 |
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author | Foesleitner, Olivia Knop, Karl Christian Lindenau, Matthias Preisner, Fabian Bäumer, Philipp Heiland, Sabine Bendszus, Martin Kronlage, Moritz |
author_facet | Foesleitner, Olivia Knop, Karl Christian Lindenau, Matthias Preisner, Fabian Bäumer, Philipp Heiland, Sabine Bendszus, Martin Kronlage, Moritz |
author_sort | Foesleitner, Olivia |
collection | PubMed |
description | Background: The aim of this study was to assess the phenotype of multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis (ALS) in quantitative MR neurography. Methods: In this prospective study, 22 patients with ALS, 8 patients with MMN, and 10 healthy volunteers were examined with 3T MR neurography, using a high-resolution fat-saturated T2-weighted sequence, diffusion-tensor imaging (DTI), and a multi-echo T2-relaxometry sequence. The quantitative biomarkers fractional anisotropy (FA), radial and axial diffusivity (RD, AD), mean diffusivity (MD), cross-sectional area (CSA), T2-relaxation time, and proton spin density (PSD) were measured in the tibial nerve at the thigh and calf, and in the median, radial, and ulnar nerves at the mid-upper arm. Results: MMN showed a characteristic imaging pattern of decreased FA (p = 0.018), increased RD (p = 0.014), increased CSA (p < 0.001), increased T2-relaxation time (p < 0.001), and increased PSD (p = 0.025) in the upper arm nerves compared to ALS and controls. ALS patients did not differ from controls in any imaging marker, nor were there any group differences in the tibial nerve (p > 0.05). Conclusions: MMN shows a characteristic pattern of quantitative DTI and T2-relaxometry parameters in the upper-arm nerves, primarily indicating demyelination. Peripheral nerve changes in ALS seem to be below the detection level of current state-of-the-art quantitative MR neurography. |
format | Online Article Text |
id | pubmed-10093201 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100932012023-04-13 Quantitative MR Neurography in Multifocal Motor Neuropathy and Amyotrophic Lateral Sclerosis Foesleitner, Olivia Knop, Karl Christian Lindenau, Matthias Preisner, Fabian Bäumer, Philipp Heiland, Sabine Bendszus, Martin Kronlage, Moritz Diagnostics (Basel) Article Background: The aim of this study was to assess the phenotype of multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis (ALS) in quantitative MR neurography. Methods: In this prospective study, 22 patients with ALS, 8 patients with MMN, and 10 healthy volunteers were examined with 3T MR neurography, using a high-resolution fat-saturated T2-weighted sequence, diffusion-tensor imaging (DTI), and a multi-echo T2-relaxometry sequence. The quantitative biomarkers fractional anisotropy (FA), radial and axial diffusivity (RD, AD), mean diffusivity (MD), cross-sectional area (CSA), T2-relaxation time, and proton spin density (PSD) were measured in the tibial nerve at the thigh and calf, and in the median, radial, and ulnar nerves at the mid-upper arm. Results: MMN showed a characteristic imaging pattern of decreased FA (p = 0.018), increased RD (p = 0.014), increased CSA (p < 0.001), increased T2-relaxation time (p < 0.001), and increased PSD (p = 0.025) in the upper arm nerves compared to ALS and controls. ALS patients did not differ from controls in any imaging marker, nor were there any group differences in the tibial nerve (p > 0.05). Conclusions: MMN shows a characteristic pattern of quantitative DTI and T2-relaxometry parameters in the upper-arm nerves, primarily indicating demyelination. Peripheral nerve changes in ALS seem to be below the detection level of current state-of-the-art quantitative MR neurography. MDPI 2023-03-25 /pmc/articles/PMC10093201/ /pubmed/37046455 http://dx.doi.org/10.3390/diagnostics13071237 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Foesleitner, Olivia Knop, Karl Christian Lindenau, Matthias Preisner, Fabian Bäumer, Philipp Heiland, Sabine Bendszus, Martin Kronlage, Moritz Quantitative MR Neurography in Multifocal Motor Neuropathy and Amyotrophic Lateral Sclerosis |
title | Quantitative MR Neurography in Multifocal Motor Neuropathy and Amyotrophic Lateral Sclerosis |
title_full | Quantitative MR Neurography in Multifocal Motor Neuropathy and Amyotrophic Lateral Sclerosis |
title_fullStr | Quantitative MR Neurography in Multifocal Motor Neuropathy and Amyotrophic Lateral Sclerosis |
title_full_unstemmed | Quantitative MR Neurography in Multifocal Motor Neuropathy and Amyotrophic Lateral Sclerosis |
title_short | Quantitative MR Neurography in Multifocal Motor Neuropathy and Amyotrophic Lateral Sclerosis |
title_sort | quantitative mr neurography in multifocal motor neuropathy and amyotrophic lateral sclerosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093201/ https://www.ncbi.nlm.nih.gov/pubmed/37046455 http://dx.doi.org/10.3390/diagnostics13071237 |
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