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Quantitative MR Neurography in Multifocal Motor Neuropathy and Amyotrophic Lateral Sclerosis

Background: The aim of this study was to assess the phenotype of multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis (ALS) in quantitative MR neurography. Methods: In this prospective study, 22 patients with ALS, 8 patients with MMN, and 10 healthy volunteers were examined with 3T MR...

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Autores principales: Foesleitner, Olivia, Knop, Karl Christian, Lindenau, Matthias, Preisner, Fabian, Bäumer, Philipp, Heiland, Sabine, Bendszus, Martin, Kronlage, Moritz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093201/
https://www.ncbi.nlm.nih.gov/pubmed/37046455
http://dx.doi.org/10.3390/diagnostics13071237
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author Foesleitner, Olivia
Knop, Karl Christian
Lindenau, Matthias
Preisner, Fabian
Bäumer, Philipp
Heiland, Sabine
Bendszus, Martin
Kronlage, Moritz
author_facet Foesleitner, Olivia
Knop, Karl Christian
Lindenau, Matthias
Preisner, Fabian
Bäumer, Philipp
Heiland, Sabine
Bendszus, Martin
Kronlage, Moritz
author_sort Foesleitner, Olivia
collection PubMed
description Background: The aim of this study was to assess the phenotype of multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis (ALS) in quantitative MR neurography. Methods: In this prospective study, 22 patients with ALS, 8 patients with MMN, and 10 healthy volunteers were examined with 3T MR neurography, using a high-resolution fat-saturated T2-weighted sequence, diffusion-tensor imaging (DTI), and a multi-echo T2-relaxometry sequence. The quantitative biomarkers fractional anisotropy (FA), radial and axial diffusivity (RD, AD), mean diffusivity (MD), cross-sectional area (CSA), T2-relaxation time, and proton spin density (PSD) were measured in the tibial nerve at the thigh and calf, and in the median, radial, and ulnar nerves at the mid-upper arm. Results: MMN showed a characteristic imaging pattern of decreased FA (p = 0.018), increased RD (p = 0.014), increased CSA (p < 0.001), increased T2-relaxation time (p < 0.001), and increased PSD (p = 0.025) in the upper arm nerves compared to ALS and controls. ALS patients did not differ from controls in any imaging marker, nor were there any group differences in the tibial nerve (p > 0.05). Conclusions: MMN shows a characteristic pattern of quantitative DTI and T2-relaxometry parameters in the upper-arm nerves, primarily indicating demyelination. Peripheral nerve changes in ALS seem to be below the detection level of current state-of-the-art quantitative MR neurography.
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spelling pubmed-100932012023-04-13 Quantitative MR Neurography in Multifocal Motor Neuropathy and Amyotrophic Lateral Sclerosis Foesleitner, Olivia Knop, Karl Christian Lindenau, Matthias Preisner, Fabian Bäumer, Philipp Heiland, Sabine Bendszus, Martin Kronlage, Moritz Diagnostics (Basel) Article Background: The aim of this study was to assess the phenotype of multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis (ALS) in quantitative MR neurography. Methods: In this prospective study, 22 patients with ALS, 8 patients with MMN, and 10 healthy volunteers were examined with 3T MR neurography, using a high-resolution fat-saturated T2-weighted sequence, diffusion-tensor imaging (DTI), and a multi-echo T2-relaxometry sequence. The quantitative biomarkers fractional anisotropy (FA), radial and axial diffusivity (RD, AD), mean diffusivity (MD), cross-sectional area (CSA), T2-relaxation time, and proton spin density (PSD) were measured in the tibial nerve at the thigh and calf, and in the median, radial, and ulnar nerves at the mid-upper arm. Results: MMN showed a characteristic imaging pattern of decreased FA (p = 0.018), increased RD (p = 0.014), increased CSA (p < 0.001), increased T2-relaxation time (p < 0.001), and increased PSD (p = 0.025) in the upper arm nerves compared to ALS and controls. ALS patients did not differ from controls in any imaging marker, nor were there any group differences in the tibial nerve (p > 0.05). Conclusions: MMN shows a characteristic pattern of quantitative DTI and T2-relaxometry parameters in the upper-arm nerves, primarily indicating demyelination. Peripheral nerve changes in ALS seem to be below the detection level of current state-of-the-art quantitative MR neurography. MDPI 2023-03-25 /pmc/articles/PMC10093201/ /pubmed/37046455 http://dx.doi.org/10.3390/diagnostics13071237 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Foesleitner, Olivia
Knop, Karl Christian
Lindenau, Matthias
Preisner, Fabian
Bäumer, Philipp
Heiland, Sabine
Bendszus, Martin
Kronlage, Moritz
Quantitative MR Neurography in Multifocal Motor Neuropathy and Amyotrophic Lateral Sclerosis
title Quantitative MR Neurography in Multifocal Motor Neuropathy and Amyotrophic Lateral Sclerosis
title_full Quantitative MR Neurography in Multifocal Motor Neuropathy and Amyotrophic Lateral Sclerosis
title_fullStr Quantitative MR Neurography in Multifocal Motor Neuropathy and Amyotrophic Lateral Sclerosis
title_full_unstemmed Quantitative MR Neurography in Multifocal Motor Neuropathy and Amyotrophic Lateral Sclerosis
title_short Quantitative MR Neurography in Multifocal Motor Neuropathy and Amyotrophic Lateral Sclerosis
title_sort quantitative mr neurography in multifocal motor neuropathy and amyotrophic lateral sclerosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093201/
https://www.ncbi.nlm.nih.gov/pubmed/37046455
http://dx.doi.org/10.3390/diagnostics13071237
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