Cargando…

Bamboo Shoots Modulate Gut Microbiota, Eliminate Obesity in High-Fat-Diet-Fed Mice and Improve Lipid Metabolism

Bamboo shoots (BS) have a variety of nutritional benefits; however, their anti-obesity effect and its underlying mechanism of action are still unclear. In this study, we investigated the protective effect of BS against high-fat diet (HFD)-induced gut dysbiosis in mice. After 12 weeks of feeding C57B...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Xiaolu, Pak, SolJu, Li, Daotong, Dong, Li, Chen, Fang, Hu, Xiaosong, Ma, Lingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093345/
https://www.ncbi.nlm.nih.gov/pubmed/37048203
http://dx.doi.org/10.3390/foods12071380
_version_ 1785023563719245824
author Zhou, Xiaolu
Pak, SolJu
Li, Daotong
Dong, Li
Chen, Fang
Hu, Xiaosong
Ma, Lingjun
author_facet Zhou, Xiaolu
Pak, SolJu
Li, Daotong
Dong, Li
Chen, Fang
Hu, Xiaosong
Ma, Lingjun
author_sort Zhou, Xiaolu
collection PubMed
description Bamboo shoots (BS) have a variety of nutritional benefits; however, their anti-obesity effect and its underlying mechanism of action are still unclear. In this study, we investigated the protective effect of BS against high-fat diet (HFD)-induced gut dysbiosis in mice. After 12 weeks of feeding C57BL/6J mice either on a normal or an HFD with or without BS, metabolic indicators, including blood lipids and glucose tolerance, were measured. 16S rRNA gene sequencing and metabolomics were used to identify alterations in gut microbiota composition and fecal metabolic profiling. The results demonstrated that BS supplementation reduced body weight by 30.56%, mitigated liver damage, and improved insulin resistance and inflammation in obese mice. In addition, BS increased short-chain fatty acid (SCFA) levels and SCFA-producing bacteria (e.g., Lachnospiraceae_NK4A136_group and Norank_f_Muribaculaceae), and reduced levels of harmful bacteria (e.g., Blautia and Burkholderia–Paraburkholderia). Finally, BS increased many beneficial fecal metabolites, such as fatty acids and bile acids, which are highly relevant to the altered gut microbiota. Based on the modulatory effect of BS on microbiota composition and gut metabolite levels observed in this study, we suggest that BS may be beneficial in treating obesity and its related complications.
format Online
Article
Text
id pubmed-10093345
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100933452023-04-13 Bamboo Shoots Modulate Gut Microbiota, Eliminate Obesity in High-Fat-Diet-Fed Mice and Improve Lipid Metabolism Zhou, Xiaolu Pak, SolJu Li, Daotong Dong, Li Chen, Fang Hu, Xiaosong Ma, Lingjun Foods Article Bamboo shoots (BS) have a variety of nutritional benefits; however, their anti-obesity effect and its underlying mechanism of action are still unclear. In this study, we investigated the protective effect of BS against high-fat diet (HFD)-induced gut dysbiosis in mice. After 12 weeks of feeding C57BL/6J mice either on a normal or an HFD with or without BS, metabolic indicators, including blood lipids and glucose tolerance, were measured. 16S rRNA gene sequencing and metabolomics were used to identify alterations in gut microbiota composition and fecal metabolic profiling. The results demonstrated that BS supplementation reduced body weight by 30.56%, mitigated liver damage, and improved insulin resistance and inflammation in obese mice. In addition, BS increased short-chain fatty acid (SCFA) levels and SCFA-producing bacteria (e.g., Lachnospiraceae_NK4A136_group and Norank_f_Muribaculaceae), and reduced levels of harmful bacteria (e.g., Blautia and Burkholderia–Paraburkholderia). Finally, BS increased many beneficial fecal metabolites, such as fatty acids and bile acids, which are highly relevant to the altered gut microbiota. Based on the modulatory effect of BS on microbiota composition and gut metabolite levels observed in this study, we suggest that BS may be beneficial in treating obesity and its related complications. MDPI 2023-03-24 /pmc/articles/PMC10093345/ /pubmed/37048203 http://dx.doi.org/10.3390/foods12071380 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhou, Xiaolu
Pak, SolJu
Li, Daotong
Dong, Li
Chen, Fang
Hu, Xiaosong
Ma, Lingjun
Bamboo Shoots Modulate Gut Microbiota, Eliminate Obesity in High-Fat-Diet-Fed Mice and Improve Lipid Metabolism
title Bamboo Shoots Modulate Gut Microbiota, Eliminate Obesity in High-Fat-Diet-Fed Mice and Improve Lipid Metabolism
title_full Bamboo Shoots Modulate Gut Microbiota, Eliminate Obesity in High-Fat-Diet-Fed Mice and Improve Lipid Metabolism
title_fullStr Bamboo Shoots Modulate Gut Microbiota, Eliminate Obesity in High-Fat-Diet-Fed Mice and Improve Lipid Metabolism
title_full_unstemmed Bamboo Shoots Modulate Gut Microbiota, Eliminate Obesity in High-Fat-Diet-Fed Mice and Improve Lipid Metabolism
title_short Bamboo Shoots Modulate Gut Microbiota, Eliminate Obesity in High-Fat-Diet-Fed Mice and Improve Lipid Metabolism
title_sort bamboo shoots modulate gut microbiota, eliminate obesity in high-fat-diet-fed mice and improve lipid metabolism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093345/
https://www.ncbi.nlm.nih.gov/pubmed/37048203
http://dx.doi.org/10.3390/foods12071380
work_keys_str_mv AT zhouxiaolu bambooshootsmodulategutmicrobiotaeliminateobesityinhighfatdietfedmiceandimprovelipidmetabolism
AT paksolju bambooshootsmodulategutmicrobiotaeliminateobesityinhighfatdietfedmiceandimprovelipidmetabolism
AT lidaotong bambooshootsmodulategutmicrobiotaeliminateobesityinhighfatdietfedmiceandimprovelipidmetabolism
AT dongli bambooshootsmodulategutmicrobiotaeliminateobesityinhighfatdietfedmiceandimprovelipidmetabolism
AT chenfang bambooshootsmodulategutmicrobiotaeliminateobesityinhighfatdietfedmiceandimprovelipidmetabolism
AT huxiaosong bambooshootsmodulategutmicrobiotaeliminateobesityinhighfatdietfedmiceandimprovelipidmetabolism
AT malingjun bambooshootsmodulategutmicrobiotaeliminateobesityinhighfatdietfedmiceandimprovelipidmetabolism