Cargando…
Current Applications of Liquid Biopsy in Gastrointestinal Cancer Disease—From Early Cancer Detection to Individualized Cancer Treatment
SIMPLE SUMMARY: Gastrointestinal (GI) cancers are a common cancer, affecting both men and women, normally diagnosed through tissue biopsies in combination with imaging techniques and standardized biomarkers leading to patient selection for local or systemic therapies. Liquid biopsies (LBs)—due to th...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093361/ https://www.ncbi.nlm.nih.gov/pubmed/37046585 http://dx.doi.org/10.3390/cancers15071924 |
_version_ | 1785023567615754240 |
---|---|
author | David, Paul Mittelstädt, Anke Kouhestani, Dina Anthuber, Anna Kahlert, Christoph Sohn, Kai Weber, Georg F. |
author_facet | David, Paul Mittelstädt, Anke Kouhestani, Dina Anthuber, Anna Kahlert, Christoph Sohn, Kai Weber, Georg F. |
author_sort | David, Paul |
collection | PubMed |
description | SIMPLE SUMMARY: Gastrointestinal (GI) cancers are a common cancer, affecting both men and women, normally diagnosed through tissue biopsies in combination with imaging techniques and standardized biomarkers leading to patient selection for local or systemic therapies. Liquid biopsies (LBs)—due to their non-invasive nature as well as low risk—are the current focus of cancer research and could be a promising tool for early cancer detection and treatment surveillance, thus leading to better patient outcomes. In this review, we provide an overview of different types of LBs enabling early detection and monitoring of GI cancers and their clinical application. ABSTRACT: Worldwide, gastrointestinal (GI) cancers account for a significant amount of cancer-related mortality. Tests that allow an early diagnosis could lead to an improvement in patient survival. Liquid biopsies (LBs) due to their non-invasive nature as well as low risk are the current focus of cancer research and could be a promising tool for early cancer detection. LB involves the sampling of any biological fluid (e.g., blood, urine, saliva) to enrich and analyze the tumor’s biological material. LBs can detect tumor-associated components such as circulating tumor DNA (ctDNA), extracellular vesicles (EVs), and circulating tumor cells (CTCs). These components can reflect the status of the disease and can facilitate clinical decisions. LBs offer a unique and new way to assess cancers at all stages of treatment, from cancer screenings to prognosis to management of multidisciplinary therapies. In this review, we will provide insights into the current status of the various types of LBs enabling early detection and monitoring of GI cancers and their use in in vitro diagnostics. |
format | Online Article Text |
id | pubmed-10093361 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100933612023-04-13 Current Applications of Liquid Biopsy in Gastrointestinal Cancer Disease—From Early Cancer Detection to Individualized Cancer Treatment David, Paul Mittelstädt, Anke Kouhestani, Dina Anthuber, Anna Kahlert, Christoph Sohn, Kai Weber, Georg F. Cancers (Basel) Review SIMPLE SUMMARY: Gastrointestinal (GI) cancers are a common cancer, affecting both men and women, normally diagnosed through tissue biopsies in combination with imaging techniques and standardized biomarkers leading to patient selection for local or systemic therapies. Liquid biopsies (LBs)—due to their non-invasive nature as well as low risk—are the current focus of cancer research and could be a promising tool for early cancer detection and treatment surveillance, thus leading to better patient outcomes. In this review, we provide an overview of different types of LBs enabling early detection and monitoring of GI cancers and their clinical application. ABSTRACT: Worldwide, gastrointestinal (GI) cancers account for a significant amount of cancer-related mortality. Tests that allow an early diagnosis could lead to an improvement in patient survival. Liquid biopsies (LBs) due to their non-invasive nature as well as low risk are the current focus of cancer research and could be a promising tool for early cancer detection. LB involves the sampling of any biological fluid (e.g., blood, urine, saliva) to enrich and analyze the tumor’s biological material. LBs can detect tumor-associated components such as circulating tumor DNA (ctDNA), extracellular vesicles (EVs), and circulating tumor cells (CTCs). These components can reflect the status of the disease and can facilitate clinical decisions. LBs offer a unique and new way to assess cancers at all stages of treatment, from cancer screenings to prognosis to management of multidisciplinary therapies. In this review, we will provide insights into the current status of the various types of LBs enabling early detection and monitoring of GI cancers and their use in in vitro diagnostics. MDPI 2023-03-23 /pmc/articles/PMC10093361/ /pubmed/37046585 http://dx.doi.org/10.3390/cancers15071924 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review David, Paul Mittelstädt, Anke Kouhestani, Dina Anthuber, Anna Kahlert, Christoph Sohn, Kai Weber, Georg F. Current Applications of Liquid Biopsy in Gastrointestinal Cancer Disease—From Early Cancer Detection to Individualized Cancer Treatment |
title | Current Applications of Liquid Biopsy in Gastrointestinal Cancer Disease—From Early Cancer Detection to Individualized Cancer Treatment |
title_full | Current Applications of Liquid Biopsy in Gastrointestinal Cancer Disease—From Early Cancer Detection to Individualized Cancer Treatment |
title_fullStr | Current Applications of Liquid Biopsy in Gastrointestinal Cancer Disease—From Early Cancer Detection to Individualized Cancer Treatment |
title_full_unstemmed | Current Applications of Liquid Biopsy in Gastrointestinal Cancer Disease—From Early Cancer Detection to Individualized Cancer Treatment |
title_short | Current Applications of Liquid Biopsy in Gastrointestinal Cancer Disease—From Early Cancer Detection to Individualized Cancer Treatment |
title_sort | current applications of liquid biopsy in gastrointestinal cancer disease—from early cancer detection to individualized cancer treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093361/ https://www.ncbi.nlm.nih.gov/pubmed/37046585 http://dx.doi.org/10.3390/cancers15071924 |
work_keys_str_mv | AT davidpaul currentapplicationsofliquidbiopsyingastrointestinalcancerdiseasefromearlycancerdetectiontoindividualizedcancertreatment AT mittelstadtanke currentapplicationsofliquidbiopsyingastrointestinalcancerdiseasefromearlycancerdetectiontoindividualizedcancertreatment AT kouhestanidina currentapplicationsofliquidbiopsyingastrointestinalcancerdiseasefromearlycancerdetectiontoindividualizedcancertreatment AT anthuberanna currentapplicationsofliquidbiopsyingastrointestinalcancerdiseasefromearlycancerdetectiontoindividualizedcancertreatment AT kahlertchristoph currentapplicationsofliquidbiopsyingastrointestinalcancerdiseasefromearlycancerdetectiontoindividualizedcancertreatment AT sohnkai currentapplicationsofliquidbiopsyingastrointestinalcancerdiseasefromearlycancerdetectiontoindividualizedcancertreatment AT webergeorgf currentapplicationsofliquidbiopsyingastrointestinalcancerdiseasefromearlycancerdetectiontoindividualizedcancertreatment |