Bing–Neel Syndrome and Coexisting Pituitary Macroadenoma in a Patient with Waldenström Macroglobulinemia Revealed by (18)F-FDG and (68)Ga-Pentixafor PET/CT

A 63-year-old man presenting with peripheral neuropathies was diagnosed of Waldenström’s macroglobulinemia, and Bing–Neel syndrome was subsequently confirmed via cerebrospinal fluid examinations. Besides involvement in bone marrow, lymph nodes, as well as the thoracic and sacral nerve root,( 68)Ga-P...

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Autores principales: Pan, Qingqing, Luo, Yaping, Cao, Xinxin, Li, Jian, Feng, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093397/
https://www.ncbi.nlm.nih.gov/pubmed/37046551
http://dx.doi.org/10.3390/diagnostics13071334
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author Pan, Qingqing
Luo, Yaping
Cao, Xinxin
Li, Jian
Feng, Jun
author_facet Pan, Qingqing
Luo, Yaping
Cao, Xinxin
Li, Jian
Feng, Jun
author_sort Pan, Qingqing
collection PubMed
description A 63-year-old man presenting with peripheral neuropathies was diagnosed of Waldenström’s macroglobulinemia, and Bing–Neel syndrome was subsequently confirmed via cerebrospinal fluid examinations. Besides involvement in bone marrow, lymph nodes, as well as the thoracic and sacral nerve root,( 68)Ga-Pentixafor PET/CT detected active tracer uptake in bilateral choroid plexus, which was negative in (18)F-FDG PET/CT, possibly suggesting the involvement of Bing–Neel syndrome. The coexisting pituitary macroadenoma was FDG-avid but negative in (68)Ga-Pentixafor PET/CT. After six cycles of chemotherapy, the follow-up PET/CT showed complete remission of the previous disease, including the high uptake of (68)Ga-Pentixafor in choroid plexus. However, the hypermetabolic pituitary macroadenoma remained unchanged.
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spelling pubmed-100933972023-04-13 Bing–Neel Syndrome and Coexisting Pituitary Macroadenoma in a Patient with Waldenström Macroglobulinemia Revealed by (18)F-FDG and (68)Ga-Pentixafor PET/CT Pan, Qingqing Luo, Yaping Cao, Xinxin Li, Jian Feng, Jun Diagnostics (Basel) Interesting Images A 63-year-old man presenting with peripheral neuropathies was diagnosed of Waldenström’s macroglobulinemia, and Bing–Neel syndrome was subsequently confirmed via cerebrospinal fluid examinations. Besides involvement in bone marrow, lymph nodes, as well as the thoracic and sacral nerve root,( 68)Ga-Pentixafor PET/CT detected active tracer uptake in bilateral choroid plexus, which was negative in (18)F-FDG PET/CT, possibly suggesting the involvement of Bing–Neel syndrome. The coexisting pituitary macroadenoma was FDG-avid but negative in (68)Ga-Pentixafor PET/CT. After six cycles of chemotherapy, the follow-up PET/CT showed complete remission of the previous disease, including the high uptake of (68)Ga-Pentixafor in choroid plexus. However, the hypermetabolic pituitary macroadenoma remained unchanged. MDPI 2023-04-03 /pmc/articles/PMC10093397/ /pubmed/37046551 http://dx.doi.org/10.3390/diagnostics13071334 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Interesting Images
Pan, Qingqing
Luo, Yaping
Cao, Xinxin
Li, Jian
Feng, Jun
Bing–Neel Syndrome and Coexisting Pituitary Macroadenoma in a Patient with Waldenström Macroglobulinemia Revealed by (18)F-FDG and (68)Ga-Pentixafor PET/CT
title Bing–Neel Syndrome and Coexisting Pituitary Macroadenoma in a Patient with Waldenström Macroglobulinemia Revealed by (18)F-FDG and (68)Ga-Pentixafor PET/CT
title_full Bing–Neel Syndrome and Coexisting Pituitary Macroadenoma in a Patient with Waldenström Macroglobulinemia Revealed by (18)F-FDG and (68)Ga-Pentixafor PET/CT
title_fullStr Bing–Neel Syndrome and Coexisting Pituitary Macroadenoma in a Patient with Waldenström Macroglobulinemia Revealed by (18)F-FDG and (68)Ga-Pentixafor PET/CT
title_full_unstemmed Bing–Neel Syndrome and Coexisting Pituitary Macroadenoma in a Patient with Waldenström Macroglobulinemia Revealed by (18)F-FDG and (68)Ga-Pentixafor PET/CT
title_short Bing–Neel Syndrome and Coexisting Pituitary Macroadenoma in a Patient with Waldenström Macroglobulinemia Revealed by (18)F-FDG and (68)Ga-Pentixafor PET/CT
title_sort bing–neel syndrome and coexisting pituitary macroadenoma in a patient with waldenström macroglobulinemia revealed by (18)f-fdg and (68)ga-pentixafor pet/ct
topic Interesting Images
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093397/
https://www.ncbi.nlm.nih.gov/pubmed/37046551
http://dx.doi.org/10.3390/diagnostics13071334
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