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Pitfalls of Thrombotic Microangiopathies in Children: Two Case Reports and Literature Review
Thrombotic microangiopathy can present itself in the form of several clinical entities, representing a real challenge for diagnosis and treatment in pediatric practice. Our article aims to explore the evolution of two rare cases of pediatric thrombotic thrombocytopenic purpura (TTP) and atypical hem...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093431/ https://www.ncbi.nlm.nih.gov/pubmed/37046448 http://dx.doi.org/10.3390/diagnostics13071228 |
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author | Mocanu, Adriana Bogos, Roxana Alexandra Lazaruc, Tudor Ilie Cianga, Anca Lavinia Lupu, Vasile Valeriu Ioniuc, Ileana Alecsa, Mirabela Lupu, Ancuta Ivanov, Anca Viorica Miron, Ingrith Crenguta Starcea, Iuliana Magdalena |
author_facet | Mocanu, Adriana Bogos, Roxana Alexandra Lazaruc, Tudor Ilie Cianga, Anca Lavinia Lupu, Vasile Valeriu Ioniuc, Ileana Alecsa, Mirabela Lupu, Ancuta Ivanov, Anca Viorica Miron, Ingrith Crenguta Starcea, Iuliana Magdalena |
author_sort | Mocanu, Adriana |
collection | PubMed |
description | Thrombotic microangiopathy can present itself in the form of several clinical entities, representing a real challenge for diagnosis and treatment in pediatric practice. Our article aims to explore the evolution of two rare cases of pediatric thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic uremic syndrome (aHUS) with extremely similar clinical pictures, which, coincidentally, presented at approximately the same time in our hospital. These cases and our literature review demonstrate the multiple facets of thrombotic microangiopathy, which can produce various determinations and salient manifestations even among the pediatric population. TTP and aHUS may represent genuine diagnostic pitfalls through the overlap of their clinical and biological findings, although they develop through fundamentally different mechanisms that require different therapeutic approaches. As a novelty, we underline that COVID-19 infection cannot be excluded as potential trigger for TTP and aHUS in our patients and we predict that other reports of such an association will follow, raising a complex question of COVID-19’s implication in the occurrence and evolution of thrombotic microangiopathies. On this matter, we conducted literature research that resulted in 15 cases of COVID-19 pediatric infections associated with either TTP or aHUS. Taking into consideration the morbidity associated with TTP and aHUS, an elaborate differential diagnosis and prompt intervention are of the essence. |
format | Online Article Text |
id | pubmed-10093431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100934312023-04-13 Pitfalls of Thrombotic Microangiopathies in Children: Two Case Reports and Literature Review Mocanu, Adriana Bogos, Roxana Alexandra Lazaruc, Tudor Ilie Cianga, Anca Lavinia Lupu, Vasile Valeriu Ioniuc, Ileana Alecsa, Mirabela Lupu, Ancuta Ivanov, Anca Viorica Miron, Ingrith Crenguta Starcea, Iuliana Magdalena Diagnostics (Basel) Review Thrombotic microangiopathy can present itself in the form of several clinical entities, representing a real challenge for diagnosis and treatment in pediatric practice. Our article aims to explore the evolution of two rare cases of pediatric thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic uremic syndrome (aHUS) with extremely similar clinical pictures, which, coincidentally, presented at approximately the same time in our hospital. These cases and our literature review demonstrate the multiple facets of thrombotic microangiopathy, which can produce various determinations and salient manifestations even among the pediatric population. TTP and aHUS may represent genuine diagnostic pitfalls through the overlap of their clinical and biological findings, although they develop through fundamentally different mechanisms that require different therapeutic approaches. As a novelty, we underline that COVID-19 infection cannot be excluded as potential trigger for TTP and aHUS in our patients and we predict that other reports of such an association will follow, raising a complex question of COVID-19’s implication in the occurrence and evolution of thrombotic microangiopathies. On this matter, we conducted literature research that resulted in 15 cases of COVID-19 pediatric infections associated with either TTP or aHUS. Taking into consideration the morbidity associated with TTP and aHUS, an elaborate differential diagnosis and prompt intervention are of the essence. MDPI 2023-03-24 /pmc/articles/PMC10093431/ /pubmed/37046448 http://dx.doi.org/10.3390/diagnostics13071228 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mocanu, Adriana Bogos, Roxana Alexandra Lazaruc, Tudor Ilie Cianga, Anca Lavinia Lupu, Vasile Valeriu Ioniuc, Ileana Alecsa, Mirabela Lupu, Ancuta Ivanov, Anca Viorica Miron, Ingrith Crenguta Starcea, Iuliana Magdalena Pitfalls of Thrombotic Microangiopathies in Children: Two Case Reports and Literature Review |
title | Pitfalls of Thrombotic Microangiopathies in Children: Two Case Reports and Literature Review |
title_full | Pitfalls of Thrombotic Microangiopathies in Children: Two Case Reports and Literature Review |
title_fullStr | Pitfalls of Thrombotic Microangiopathies in Children: Two Case Reports and Literature Review |
title_full_unstemmed | Pitfalls of Thrombotic Microangiopathies in Children: Two Case Reports and Literature Review |
title_short | Pitfalls of Thrombotic Microangiopathies in Children: Two Case Reports and Literature Review |
title_sort | pitfalls of thrombotic microangiopathies in children: two case reports and literature review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093431/ https://www.ncbi.nlm.nih.gov/pubmed/37046448 http://dx.doi.org/10.3390/diagnostics13071228 |
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