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Retinal Development in a Precocial Bird Species, the Quail (Coturnix coturnix, Linnaeus 1758)

The quail (Coturnix coturnix, Linnaeus 1758), a notable model used in developmental biology, is a precocial bird species in which the processes of retinal cell differentiation and retinal histogenesis have been poorly studied. The purpose of the present research is to examine the retinogenesis in th...

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Autores principales: Álvarez-Hernán, Guadalupe, de Mera-Rodríguez, José Antonio, Calle-Guisado, Violeta, Martín-Partido, Gervasio, Rodríguez-León, Joaquín, Francisco-Morcillo, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093483/
https://www.ncbi.nlm.nih.gov/pubmed/37048062
http://dx.doi.org/10.3390/cells12070989
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author Álvarez-Hernán, Guadalupe
de Mera-Rodríguez, José Antonio
Calle-Guisado, Violeta
Martín-Partido, Gervasio
Rodríguez-León, Joaquín
Francisco-Morcillo, Javier
author_facet Álvarez-Hernán, Guadalupe
de Mera-Rodríguez, José Antonio
Calle-Guisado, Violeta
Martín-Partido, Gervasio
Rodríguez-León, Joaquín
Francisco-Morcillo, Javier
author_sort Álvarez-Hernán, Guadalupe
collection PubMed
description The quail (Coturnix coturnix, Linnaeus 1758), a notable model used in developmental biology, is a precocial bird species in which the processes of retinal cell differentiation and retinal histogenesis have been poorly studied. The purpose of the present research is to examine the retinogenesis in this bird species immunohistochemically and compare the results with those from previous studies in precocial and altricial birds. We found that the first PCNA-negative nuclei are detected at Stage (St) 21 in the vitreal region of the neuroblastic layer, coinciding topographically with the first αTubAc-/Tuj1-/Isl1-immunoreactive differentiating ganglion cells. At St28, the first Prox1-immunoreactive nuclei can be distinguished in the vitreal side of the neuroblastic layer (NbL), but also the first visinin-immunoreactive photoreceptors in the scleral surface. The inner plexiform layer (IPL) emerges at St32, and the outer plexiform layer (OPL) becomes visible at St35—the stage in which the first GS-immunoreactive Müller cells are distinguishable. Newly hatched animals show a well-developed stratified retina in which the PCNA-and pHisH3-immunoreactivies are absent. Therefore, retinal cell differentiation in the quail progresses in the stereotyped order conserved among vertebrates, in which ganglion cells initially appear and are followed by amacrine cells, horizontal cells, and photoreceptors. Müller glia are one of the last cell types to be born. Plexiform layers emerge following a vitreal-to-scleral gradient. Finally, our results suggest that there are no significant differences in the timing of different events involved in retinal maturation between the quail and the chicken, but the same events are delayed in an altricial bird species.
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spelling pubmed-100934832023-04-13 Retinal Development in a Precocial Bird Species, the Quail (Coturnix coturnix, Linnaeus 1758) Álvarez-Hernán, Guadalupe de Mera-Rodríguez, José Antonio Calle-Guisado, Violeta Martín-Partido, Gervasio Rodríguez-León, Joaquín Francisco-Morcillo, Javier Cells Article The quail (Coturnix coturnix, Linnaeus 1758), a notable model used in developmental biology, is a precocial bird species in which the processes of retinal cell differentiation and retinal histogenesis have been poorly studied. The purpose of the present research is to examine the retinogenesis in this bird species immunohistochemically and compare the results with those from previous studies in precocial and altricial birds. We found that the first PCNA-negative nuclei are detected at Stage (St) 21 in the vitreal region of the neuroblastic layer, coinciding topographically with the first αTubAc-/Tuj1-/Isl1-immunoreactive differentiating ganglion cells. At St28, the first Prox1-immunoreactive nuclei can be distinguished in the vitreal side of the neuroblastic layer (NbL), but also the first visinin-immunoreactive photoreceptors in the scleral surface. The inner plexiform layer (IPL) emerges at St32, and the outer plexiform layer (OPL) becomes visible at St35—the stage in which the first GS-immunoreactive Müller cells are distinguishable. Newly hatched animals show a well-developed stratified retina in which the PCNA-and pHisH3-immunoreactivies are absent. Therefore, retinal cell differentiation in the quail progresses in the stereotyped order conserved among vertebrates, in which ganglion cells initially appear and are followed by amacrine cells, horizontal cells, and photoreceptors. Müller glia are one of the last cell types to be born. Plexiform layers emerge following a vitreal-to-scleral gradient. Finally, our results suggest that there are no significant differences in the timing of different events involved in retinal maturation between the quail and the chicken, but the same events are delayed in an altricial bird species. MDPI 2023-03-23 /pmc/articles/PMC10093483/ /pubmed/37048062 http://dx.doi.org/10.3390/cells12070989 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Álvarez-Hernán, Guadalupe
de Mera-Rodríguez, José Antonio
Calle-Guisado, Violeta
Martín-Partido, Gervasio
Rodríguez-León, Joaquín
Francisco-Morcillo, Javier
Retinal Development in a Precocial Bird Species, the Quail (Coturnix coturnix, Linnaeus 1758)
title Retinal Development in a Precocial Bird Species, the Quail (Coturnix coturnix, Linnaeus 1758)
title_full Retinal Development in a Precocial Bird Species, the Quail (Coturnix coturnix, Linnaeus 1758)
title_fullStr Retinal Development in a Precocial Bird Species, the Quail (Coturnix coturnix, Linnaeus 1758)
title_full_unstemmed Retinal Development in a Precocial Bird Species, the Quail (Coturnix coturnix, Linnaeus 1758)
title_short Retinal Development in a Precocial Bird Species, the Quail (Coturnix coturnix, Linnaeus 1758)
title_sort retinal development in a precocial bird species, the quail (coturnix coturnix, linnaeus 1758)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093483/
https://www.ncbi.nlm.nih.gov/pubmed/37048062
http://dx.doi.org/10.3390/cells12070989
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