Chalcone Derivative CX258 Suppresses Colorectal Cancer via Inhibiting the TOP2A/Wnt/β-Catenin Signaling

The deregulation in the Wnt/β-catenin signaling pathway is associated with many human cancers, particularly colorectal cancer (CRC) and, therefore, represents a promising target for drug development. We have screened over 300 semisynthetic and natural compounds using a Wnt reporter assay and identif...

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Detalles Bibliográficos
Autores principales: Chen, Xi, Lv, Xiaocheng, Gao, Lijie, Liu, Jiawei, Wang, Wei, Guo, Lichao, Frasinyuk, Mykhaylo S., Zhang, Wen, Watt, David S., Liu, Chunming, Liu, Xifu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093515/
https://www.ncbi.nlm.nih.gov/pubmed/37048139
http://dx.doi.org/10.3390/cells12071066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093515/
https://www.ncbi.nlm.nih.gov/pubmed/37048139
http://dx.doi.org/10.3390/cells12071066

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