Cargando…

What Can Trigger Spontaneous Regression of Breast Cancer?

Background: Spontaneous regression of tumors is a rare phenomenon in which cancer volume is reduced or, alternatively, a tumor completely disappears in the absence of any pharmacological treatment. This phenomenon has previously been described in several tumors, such as neuroblastomas, testicular ma...

Descripción completa

Detalles Bibliográficos
Autores principales: D’Alessandris, Nicoletta, Santoro, Angela, Arciuolo, Damiano, Angelico, Giuseppe, Valente, Michele, Scaglione, Giulia, Sfregola, Stefania, Carlino, Angela, Navarra, Elena, Mulè, Antonino, Zannoni, Gian Franco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093529/
https://www.ncbi.nlm.nih.gov/pubmed/37046442
http://dx.doi.org/10.3390/diagnostics13071224
_version_ 1785023608230248448
author D’Alessandris, Nicoletta
Santoro, Angela
Arciuolo, Damiano
Angelico, Giuseppe
Valente, Michele
Scaglione, Giulia
Sfregola, Stefania
Carlino, Angela
Navarra, Elena
Mulè, Antonino
Zannoni, Gian Franco
author_facet D’Alessandris, Nicoletta
Santoro, Angela
Arciuolo, Damiano
Angelico, Giuseppe
Valente, Michele
Scaglione, Giulia
Sfregola, Stefania
Carlino, Angela
Navarra, Elena
Mulè, Antonino
Zannoni, Gian Franco
author_sort D’Alessandris, Nicoletta
collection PubMed
description Background: Spontaneous regression of tumors is a rare phenomenon in which cancer volume is reduced or, alternatively, a tumor completely disappears in the absence of any pharmacological treatment. This phenomenon has previously been described in several tumors, such as neuroblastomas, testicular malignancies, renal cell carcinomas, melanomas, and lymphomas. Spontaneous remission has also been documented in breast cancer; however, it represents an extremely rare and poorly understood phenomenon, with only a few reported cases in the literature. Methods: We herein report two cases of breast cancer that showed spontaneous tumor regression in the surgical specimen after a pathologically confirmed diagnosis of invasive breast cancer in core needle biopsy samples. Results: Macroscopically, both the surgical samples revealed a whitish, fibrous area with a rubbery consistency. On histological examination, diffuse fibrous tissue, hemosiderin deposition, and chronic inflammation were observed. The first case showed the complete disappearance of the tumor, whereas the second case showed just a small (3 mm), residual nest of neoplastic cells. Conclusions: Although spontaneous regression of breast cancer is a rare event, it is important to know that it might happen. It is also of great importance to try to better explain, over time, its underlying mechanism. This knowledge could help us to further develop cancer prevention methods and predict the clinical course of these kinds of neoplasms.
format Online
Article
Text
id pubmed-10093529
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100935292023-04-13 What Can Trigger Spontaneous Regression of Breast Cancer? D’Alessandris, Nicoletta Santoro, Angela Arciuolo, Damiano Angelico, Giuseppe Valente, Michele Scaglione, Giulia Sfregola, Stefania Carlino, Angela Navarra, Elena Mulè, Antonino Zannoni, Gian Franco Diagnostics (Basel) Case Report Background: Spontaneous regression of tumors is a rare phenomenon in which cancer volume is reduced or, alternatively, a tumor completely disappears in the absence of any pharmacological treatment. This phenomenon has previously been described in several tumors, such as neuroblastomas, testicular malignancies, renal cell carcinomas, melanomas, and lymphomas. Spontaneous remission has also been documented in breast cancer; however, it represents an extremely rare and poorly understood phenomenon, with only a few reported cases in the literature. Methods: We herein report two cases of breast cancer that showed spontaneous tumor regression in the surgical specimen after a pathologically confirmed diagnosis of invasive breast cancer in core needle biopsy samples. Results: Macroscopically, both the surgical samples revealed a whitish, fibrous area with a rubbery consistency. On histological examination, diffuse fibrous tissue, hemosiderin deposition, and chronic inflammation were observed. The first case showed the complete disappearance of the tumor, whereas the second case showed just a small (3 mm), residual nest of neoplastic cells. Conclusions: Although spontaneous regression of breast cancer is a rare event, it is important to know that it might happen. It is also of great importance to try to better explain, over time, its underlying mechanism. This knowledge could help us to further develop cancer prevention methods and predict the clinical course of these kinds of neoplasms. MDPI 2023-03-24 /pmc/articles/PMC10093529/ /pubmed/37046442 http://dx.doi.org/10.3390/diagnostics13071224 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
D’Alessandris, Nicoletta
Santoro, Angela
Arciuolo, Damiano
Angelico, Giuseppe
Valente, Michele
Scaglione, Giulia
Sfregola, Stefania
Carlino, Angela
Navarra, Elena
Mulè, Antonino
Zannoni, Gian Franco
What Can Trigger Spontaneous Regression of Breast Cancer?
title What Can Trigger Spontaneous Regression of Breast Cancer?
title_full What Can Trigger Spontaneous Regression of Breast Cancer?
title_fullStr What Can Trigger Spontaneous Regression of Breast Cancer?
title_full_unstemmed What Can Trigger Spontaneous Regression of Breast Cancer?
title_short What Can Trigger Spontaneous Regression of Breast Cancer?
title_sort what can trigger spontaneous regression of breast cancer?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093529/
https://www.ncbi.nlm.nih.gov/pubmed/37046442
http://dx.doi.org/10.3390/diagnostics13071224
work_keys_str_mv AT dalessandrisnicoletta whatcantriggerspontaneousregressionofbreastcancer
AT santoroangela whatcantriggerspontaneousregressionofbreastcancer
AT arciuolodamiano whatcantriggerspontaneousregressionofbreastcancer
AT angelicogiuseppe whatcantriggerspontaneousregressionofbreastcancer
AT valentemichele whatcantriggerspontaneousregressionofbreastcancer
AT scaglionegiulia whatcantriggerspontaneousregressionofbreastcancer
AT sfregolastefania whatcantriggerspontaneousregressionofbreastcancer
AT carlinoangela whatcantriggerspontaneousregressionofbreastcancer
AT navarraelena whatcantriggerspontaneousregressionofbreastcancer
AT muleantonino whatcantriggerspontaneousregressionofbreastcancer
AT zannonigianfranco whatcantriggerspontaneousregressionofbreastcancer