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Radiation-Induced Retinopathy and Optic Neuropathy after Radiation Therapy for Brain, Head, and Neck Tumors: A Systematic Review

SIMPLE SUMMARY: Retinopathy and optic neuropathy are well-known, severe ocular complications in patients undergoing radiation therapy for brain, head, and neck cancer. However, little is known about the prevalence and dose–response relationship of retinopathy and optic neuropathy in these patients....

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Autores principales: Kinaci-Tas, Buket, Alderliesten, Tanja, Verbraak, Frank D., Rasch, Coen R. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093581/
https://www.ncbi.nlm.nih.gov/pubmed/37046660
http://dx.doi.org/10.3390/cancers15071999
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author Kinaci-Tas, Buket
Alderliesten, Tanja
Verbraak, Frank D.
Rasch, Coen R. N.
author_facet Kinaci-Tas, Buket
Alderliesten, Tanja
Verbraak, Frank D.
Rasch, Coen R. N.
author_sort Kinaci-Tas, Buket
collection PubMed
description SIMPLE SUMMARY: Retinopathy and optic neuropathy are well-known, severe ocular complications in patients undergoing radiation therapy for brain, head, and neck cancer. However, little is known about the prevalence and dose–response relationship of retinopathy and optic neuropathy in these patients. More knowledge about the prevalence and dose–response relationship may contribute to developing a high-precision radiation therapy approach. ABSTRACT: Background: Patients with brain, head, and neck tumors experience a decline in their quality of life due to radiation retinopathy and optic neuropathy. Little is known about the dose–response relationship and patient characteristics. We aimed to systematically review the prevalence of radiation retinopathy and optic neuropathy. Method: The primary outcome was the pooled prevalence of radiation retinopathy and optic neuropathy. The secondary outcome included the effect of the total radiation dose prescribed for the tumor according to the patient’s characteristics. Furthermore, we aimed to evaluate the radiation dose parameters for organs at risk of radiation retinopathy and optic neuropathy. Results: The pooled prevalence was 3.8%. No retinopathy was reported for the tumor’s prescribed dose of <50 Gy. Optic neuropathy was more prevalent for a prescribed dose of >50 Gy than <50 Gy. We observed a higher prevalence rate for retinopathy (6.0%) than optic neuropathy (2.0%). Insufficient data on the dose for organs at risk were reported. Conclusion: The prevalence of radiation retinopathy was higher compared to optic neuropathy. This review emphasizes the need for future studies considering retinopathy and optic neuropathy as primary objective parameters.
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spelling pubmed-100935812023-04-13 Radiation-Induced Retinopathy and Optic Neuropathy after Radiation Therapy for Brain, Head, and Neck Tumors: A Systematic Review Kinaci-Tas, Buket Alderliesten, Tanja Verbraak, Frank D. Rasch, Coen R. N. Cancers (Basel) Systematic Review SIMPLE SUMMARY: Retinopathy and optic neuropathy are well-known, severe ocular complications in patients undergoing radiation therapy for brain, head, and neck cancer. However, little is known about the prevalence and dose–response relationship of retinopathy and optic neuropathy in these patients. More knowledge about the prevalence and dose–response relationship may contribute to developing a high-precision radiation therapy approach. ABSTRACT: Background: Patients with brain, head, and neck tumors experience a decline in their quality of life due to radiation retinopathy and optic neuropathy. Little is known about the dose–response relationship and patient characteristics. We aimed to systematically review the prevalence of radiation retinopathy and optic neuropathy. Method: The primary outcome was the pooled prevalence of radiation retinopathy and optic neuropathy. The secondary outcome included the effect of the total radiation dose prescribed for the tumor according to the patient’s characteristics. Furthermore, we aimed to evaluate the radiation dose parameters for organs at risk of radiation retinopathy and optic neuropathy. Results: The pooled prevalence was 3.8%. No retinopathy was reported for the tumor’s prescribed dose of <50 Gy. Optic neuropathy was more prevalent for a prescribed dose of >50 Gy than <50 Gy. We observed a higher prevalence rate for retinopathy (6.0%) than optic neuropathy (2.0%). Insufficient data on the dose for organs at risk were reported. Conclusion: The prevalence of radiation retinopathy was higher compared to optic neuropathy. This review emphasizes the need for future studies considering retinopathy and optic neuropathy as primary objective parameters. MDPI 2023-03-27 /pmc/articles/PMC10093581/ /pubmed/37046660 http://dx.doi.org/10.3390/cancers15071999 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Kinaci-Tas, Buket
Alderliesten, Tanja
Verbraak, Frank D.
Rasch, Coen R. N.
Radiation-Induced Retinopathy and Optic Neuropathy after Radiation Therapy for Brain, Head, and Neck Tumors: A Systematic Review
title Radiation-Induced Retinopathy and Optic Neuropathy after Radiation Therapy for Brain, Head, and Neck Tumors: A Systematic Review
title_full Radiation-Induced Retinopathy and Optic Neuropathy after Radiation Therapy for Brain, Head, and Neck Tumors: A Systematic Review
title_fullStr Radiation-Induced Retinopathy and Optic Neuropathy after Radiation Therapy for Brain, Head, and Neck Tumors: A Systematic Review
title_full_unstemmed Radiation-Induced Retinopathy and Optic Neuropathy after Radiation Therapy for Brain, Head, and Neck Tumors: A Systematic Review
title_short Radiation-Induced Retinopathy and Optic Neuropathy after Radiation Therapy for Brain, Head, and Neck Tumors: A Systematic Review
title_sort radiation-induced retinopathy and optic neuropathy after radiation therapy for brain, head, and neck tumors: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093581/
https://www.ncbi.nlm.nih.gov/pubmed/37046660
http://dx.doi.org/10.3390/cancers15071999
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