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The Clinical Significance of Incidental GIT Uptake on PET/CT: Radiologic, Endoscopic, and Pathologic Correlation

Incidental gastrointestinal tract (GIT) [18F]-Fluorodeoxyglucose (FDG) uptake in positron emission technology/computed tomography (PET/CT) is an unexpected and often complicated finding for clinicians. This retrospective study reviewed 8991 charts of patients who underwent PET/CT: 440 patients had i...

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Autores principales: Hosni, Mohammad N., Kassas, Mutaz, Itani, Mohamad I., Rahal, Mahmoud A., Al-Zakleet, Safaa, El-Jebai, Malak, Abi-Ghanem, Alain S., Moukaddam, Hicham, Haidar, Mohamad, Vinjamuri, Sobhan, Shaib, Yasser H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093625/
https://www.ncbi.nlm.nih.gov/pubmed/37046516
http://dx.doi.org/10.3390/diagnostics13071297
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author Hosni, Mohammad N.
Kassas, Mutaz
Itani, Mohamad I.
Rahal, Mahmoud A.
Al-Zakleet, Safaa
El-Jebai, Malak
Abi-Ghanem, Alain S.
Moukaddam, Hicham
Haidar, Mohamad
Vinjamuri, Sobhan
Shaib, Yasser H.
author_facet Hosni, Mohammad N.
Kassas, Mutaz
Itani, Mohamad I.
Rahal, Mahmoud A.
Al-Zakleet, Safaa
El-Jebai, Malak
Abi-Ghanem, Alain S.
Moukaddam, Hicham
Haidar, Mohamad
Vinjamuri, Sobhan
Shaib, Yasser H.
author_sort Hosni, Mohammad N.
collection PubMed
description Incidental gastrointestinal tract (GIT) [18F]-Fluorodeoxyglucose (FDG) uptake in positron emission technology/computed tomography (PET/CT) is an unexpected and often complicated finding for clinicians. This retrospective study reviewed 8991 charts of patients who underwent PET/CT: 440 patients had incidental GIT uptake, of which 80 underwent endoscopy. Patient characteristics, imaging parameters, and endoscopic findings were studied. Of the 80 patients, 31 had cancer/pre-cancer lesions (16 carcinomas; 15 pre-malignant polyps). Compared to patients with benign/absent lesions, patients with cancer/pre-cancer lesions were significantly older (p = 0.01), underwent PET/CT for primary evaluation/staging of cancer (p = 0.03), had focal GIT uptake (p = 0.04), and had lower GIT uptake (p = 0.004). Among patients with focal uptake, an SUVmax of 9.2 had the highest sensitivity (0.76) and specificity (0.885) in detecting cancer/pre-cancerous lesions. Lower GIT uptake was most common in the sigmoid colon, and upper GIT uptake was most frequent in the stomach. In a bivariate analysis, predictors of cancer/pre-cancer were older age, PET/CT indicated for primary evaluation, focal uptake, uptake in the lower GIT, and higher SUVmax. Further endoscopic investigation is warranted for patients with incidental GIT uptake, especially in the elderly or those presenting for primary evaluation with PET/CT, with the following findings on imaging: lower GIT uptake, focal uptake, or high SUVmax.
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spelling pubmed-100936252023-04-13 The Clinical Significance of Incidental GIT Uptake on PET/CT: Radiologic, Endoscopic, and Pathologic Correlation Hosni, Mohammad N. Kassas, Mutaz Itani, Mohamad I. Rahal, Mahmoud A. Al-Zakleet, Safaa El-Jebai, Malak Abi-Ghanem, Alain S. Moukaddam, Hicham Haidar, Mohamad Vinjamuri, Sobhan Shaib, Yasser H. Diagnostics (Basel) Article Incidental gastrointestinal tract (GIT) [18F]-Fluorodeoxyglucose (FDG) uptake in positron emission technology/computed tomography (PET/CT) is an unexpected and often complicated finding for clinicians. This retrospective study reviewed 8991 charts of patients who underwent PET/CT: 440 patients had incidental GIT uptake, of which 80 underwent endoscopy. Patient characteristics, imaging parameters, and endoscopic findings were studied. Of the 80 patients, 31 had cancer/pre-cancer lesions (16 carcinomas; 15 pre-malignant polyps). Compared to patients with benign/absent lesions, patients with cancer/pre-cancer lesions were significantly older (p = 0.01), underwent PET/CT for primary evaluation/staging of cancer (p = 0.03), had focal GIT uptake (p = 0.04), and had lower GIT uptake (p = 0.004). Among patients with focal uptake, an SUVmax of 9.2 had the highest sensitivity (0.76) and specificity (0.885) in detecting cancer/pre-cancerous lesions. Lower GIT uptake was most common in the sigmoid colon, and upper GIT uptake was most frequent in the stomach. In a bivariate analysis, predictors of cancer/pre-cancer were older age, PET/CT indicated for primary evaluation, focal uptake, uptake in the lower GIT, and higher SUVmax. Further endoscopic investigation is warranted for patients with incidental GIT uptake, especially in the elderly or those presenting for primary evaluation with PET/CT, with the following findings on imaging: lower GIT uptake, focal uptake, or high SUVmax. MDPI 2023-03-30 /pmc/articles/PMC10093625/ /pubmed/37046516 http://dx.doi.org/10.3390/diagnostics13071297 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hosni, Mohammad N.
Kassas, Mutaz
Itani, Mohamad I.
Rahal, Mahmoud A.
Al-Zakleet, Safaa
El-Jebai, Malak
Abi-Ghanem, Alain S.
Moukaddam, Hicham
Haidar, Mohamad
Vinjamuri, Sobhan
Shaib, Yasser H.
The Clinical Significance of Incidental GIT Uptake on PET/CT: Radiologic, Endoscopic, and Pathologic Correlation
title The Clinical Significance of Incidental GIT Uptake on PET/CT: Radiologic, Endoscopic, and Pathologic Correlation
title_full The Clinical Significance of Incidental GIT Uptake on PET/CT: Radiologic, Endoscopic, and Pathologic Correlation
title_fullStr The Clinical Significance of Incidental GIT Uptake on PET/CT: Radiologic, Endoscopic, and Pathologic Correlation
title_full_unstemmed The Clinical Significance of Incidental GIT Uptake on PET/CT: Radiologic, Endoscopic, and Pathologic Correlation
title_short The Clinical Significance of Incidental GIT Uptake on PET/CT: Radiologic, Endoscopic, and Pathologic Correlation
title_sort clinical significance of incidental git uptake on pet/ct: radiologic, endoscopic, and pathologic correlation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093625/
https://www.ncbi.nlm.nih.gov/pubmed/37046516
http://dx.doi.org/10.3390/diagnostics13071297
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