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Comparison of Standard and New Iron Status Biomarkers: A Prospective Cohort Study in Sepsis Patients

Both iron deficiency (ID) and iron overload can have negative effects on the risk and course of infection. Therefore, the ability to accurately assess iron status in these patients is of the utmost importance. Systemic inflammation in sepsis patients affects the results of standard iron biomarkers a...

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Autores principales: Czempik, Piotr F., Wiórek, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093794/
https://www.ncbi.nlm.nih.gov/pubmed/37046922
http://dx.doi.org/10.3390/healthcare11070995
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author Czempik, Piotr F.
Wiórek, Agnieszka
author_facet Czempik, Piotr F.
Wiórek, Agnieszka
author_sort Czempik, Piotr F.
collection PubMed
description Both iron deficiency (ID) and iron overload can have negative effects on the risk and course of infection. Therefore, the ability to accurately assess iron status in these patients is of the utmost importance. Systemic inflammation in sepsis patients affects the results of standard iron biomarkers and makes accurate diagnosis of ID problematic. The aim of our study was to analyze the association between widely available standard iron biomarkers and selected new iron biomarkers in various iron status subgroups among sepsis patients. Consecutive patients diagnosed with sepsis or septic shock and procalcitonin concentration > 0.5 ng/mL were enrolled. The following iron biomarkers were determined: iron, ferritin, transferrin, transferrin saturation, reticulocyte (Ret) number and percentage, Ret hemoglobin equivalent, Ret fluorescence subpopulations, and hepcidin concentration. The study group comprised 90 study subjects. There were 42 (47%) patients with normal iron status, 6 (6%) with ID without anemia, and 42 (47%) with ID anemia. No meaningful correlation exists between standard and new iron biomarkers in various iron status subgroups among sepsis patients. Therefore, standard iron biomarkers cannot be used to diagnose ID in this cohort.
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spelling pubmed-100937942023-04-13 Comparison of Standard and New Iron Status Biomarkers: A Prospective Cohort Study in Sepsis Patients Czempik, Piotr F. Wiórek, Agnieszka Healthcare (Basel) Article Both iron deficiency (ID) and iron overload can have negative effects on the risk and course of infection. Therefore, the ability to accurately assess iron status in these patients is of the utmost importance. Systemic inflammation in sepsis patients affects the results of standard iron biomarkers and makes accurate diagnosis of ID problematic. The aim of our study was to analyze the association between widely available standard iron biomarkers and selected new iron biomarkers in various iron status subgroups among sepsis patients. Consecutive patients diagnosed with sepsis or septic shock and procalcitonin concentration > 0.5 ng/mL were enrolled. The following iron biomarkers were determined: iron, ferritin, transferrin, transferrin saturation, reticulocyte (Ret) number and percentage, Ret hemoglobin equivalent, Ret fluorescence subpopulations, and hepcidin concentration. The study group comprised 90 study subjects. There were 42 (47%) patients with normal iron status, 6 (6%) with ID without anemia, and 42 (47%) with ID anemia. No meaningful correlation exists between standard and new iron biomarkers in various iron status subgroups among sepsis patients. Therefore, standard iron biomarkers cannot be used to diagnose ID in this cohort. MDPI 2023-03-30 /pmc/articles/PMC10093794/ /pubmed/37046922 http://dx.doi.org/10.3390/healthcare11070995 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Czempik, Piotr F.
Wiórek, Agnieszka
Comparison of Standard and New Iron Status Biomarkers: A Prospective Cohort Study in Sepsis Patients
title Comparison of Standard and New Iron Status Biomarkers: A Prospective Cohort Study in Sepsis Patients
title_full Comparison of Standard and New Iron Status Biomarkers: A Prospective Cohort Study in Sepsis Patients
title_fullStr Comparison of Standard and New Iron Status Biomarkers: A Prospective Cohort Study in Sepsis Patients
title_full_unstemmed Comparison of Standard and New Iron Status Biomarkers: A Prospective Cohort Study in Sepsis Patients
title_short Comparison of Standard and New Iron Status Biomarkers: A Prospective Cohort Study in Sepsis Patients
title_sort comparison of standard and new iron status biomarkers: a prospective cohort study in sepsis patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093794/
https://www.ncbi.nlm.nih.gov/pubmed/37046922
http://dx.doi.org/10.3390/healthcare11070995
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