Cargando…

Analgesic Efficacy of COX-2 Inhibitors in Periodontal Surgery: A Systematic Review and Meta-Analysis

The objective of this systematic review and meta-analysis was to evaluate the analgesic efficacy of COX-2 inhibitors versus other drugs in periodontal surgery. Two researchers searched PubMed, Google Scholar, ACM Digital, BASE, EBSCOhost, Scopus, or Web of Science for clinical trials using various c...

Descripción completa

Detalles Bibliográficos
Autores principales: Isiordia-Espinoza, Mario Alberto, Gómez-Sánchez, Eduardo, Mora-Falcón, Itzel Joselyn, Amador-Beas, Iván Agustín, Hernández-Gómez, Adriana, Serafín-Higuera, Nicolás Addiel, Franco-de la Torre, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093797/
https://www.ncbi.nlm.nih.gov/pubmed/37046983
http://dx.doi.org/10.3390/healthcare11071054
_version_ 1785023672605474816
author Isiordia-Espinoza, Mario Alberto
Gómez-Sánchez, Eduardo
Mora-Falcón, Itzel Joselyn
Amador-Beas, Iván Agustín
Hernández-Gómez, Adriana
Serafín-Higuera, Nicolás Addiel
Franco-de la Torre, Lorenzo
author_facet Isiordia-Espinoza, Mario Alberto
Gómez-Sánchez, Eduardo
Mora-Falcón, Itzel Joselyn
Amador-Beas, Iván Agustín
Hernández-Gómez, Adriana
Serafín-Higuera, Nicolás Addiel
Franco-de la Torre, Lorenzo
author_sort Isiordia-Espinoza, Mario Alberto
collection PubMed
description The objective of this systematic review and meta-analysis was to evaluate the analgesic efficacy of COX-2 inhibitors versus other drugs in periodontal surgery. Two researchers searched PubMed, Google Scholar, ACM Digital, BASE, EBSCOhost, Scopus, or Web of Science for clinical trials using various combinations of words. All articles that met the selection criteria were assessed using the Cochrane Collaboration’s risk of bias tool. For data analysis, the inverse variance and mean difference statistical method was used with Review Manager 5.3 software for Windows. According to the conclusion of each study (qualitative evaluation), only one clinical trial had results in favor of a COX-2 inhibitor when compared to placebo, one clinical study informed that a COX-2 was better that an active control, four studies showed similar analgesic efficacy to active controls, and one clinical study informed the analgesic effect of one celecoxib-caffeine combination in comparison with celecoxib alone and placebo (n = 337). The COX-2 inhibitors showed a decrease in the rescue analgesic consumption (n = 138; I(2) = 15%; mean difference = −0.31; 95%CIs = −0.6 to −0.01), and lower pain intensity at four hours (n = 178; I2 = 0%; mean difference = −2.25; 95%CIs = −2.94 to −1.55; p = 0.00001) when compared to active controls after periodontal surgery. In conclusion, the data indicate that COX-2 agents produce better pain relief in comparison to placebo and other drugs after periodontal surgery.
format Online
Article
Text
id pubmed-10093797
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100937972023-04-13 Analgesic Efficacy of COX-2 Inhibitors in Periodontal Surgery: A Systematic Review and Meta-Analysis Isiordia-Espinoza, Mario Alberto Gómez-Sánchez, Eduardo Mora-Falcón, Itzel Joselyn Amador-Beas, Iván Agustín Hernández-Gómez, Adriana Serafín-Higuera, Nicolás Addiel Franco-de la Torre, Lorenzo Healthcare (Basel) Systematic Review The objective of this systematic review and meta-analysis was to evaluate the analgesic efficacy of COX-2 inhibitors versus other drugs in periodontal surgery. Two researchers searched PubMed, Google Scholar, ACM Digital, BASE, EBSCOhost, Scopus, or Web of Science for clinical trials using various combinations of words. All articles that met the selection criteria were assessed using the Cochrane Collaboration’s risk of bias tool. For data analysis, the inverse variance and mean difference statistical method was used with Review Manager 5.3 software for Windows. According to the conclusion of each study (qualitative evaluation), only one clinical trial had results in favor of a COX-2 inhibitor when compared to placebo, one clinical study informed that a COX-2 was better that an active control, four studies showed similar analgesic efficacy to active controls, and one clinical study informed the analgesic effect of one celecoxib-caffeine combination in comparison with celecoxib alone and placebo (n = 337). The COX-2 inhibitors showed a decrease in the rescue analgesic consumption (n = 138; I(2) = 15%; mean difference = −0.31; 95%CIs = −0.6 to −0.01), and lower pain intensity at four hours (n = 178; I2 = 0%; mean difference = −2.25; 95%CIs = −2.94 to −1.55; p = 0.00001) when compared to active controls after periodontal surgery. In conclusion, the data indicate that COX-2 agents produce better pain relief in comparison to placebo and other drugs after periodontal surgery. MDPI 2023-04-06 /pmc/articles/PMC10093797/ /pubmed/37046983 http://dx.doi.org/10.3390/healthcare11071054 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Isiordia-Espinoza, Mario Alberto
Gómez-Sánchez, Eduardo
Mora-Falcón, Itzel Joselyn
Amador-Beas, Iván Agustín
Hernández-Gómez, Adriana
Serafín-Higuera, Nicolás Addiel
Franco-de la Torre, Lorenzo
Analgesic Efficacy of COX-2 Inhibitors in Periodontal Surgery: A Systematic Review and Meta-Analysis
title Analgesic Efficacy of COX-2 Inhibitors in Periodontal Surgery: A Systematic Review and Meta-Analysis
title_full Analgesic Efficacy of COX-2 Inhibitors in Periodontal Surgery: A Systematic Review and Meta-Analysis
title_fullStr Analgesic Efficacy of COX-2 Inhibitors in Periodontal Surgery: A Systematic Review and Meta-Analysis
title_full_unstemmed Analgesic Efficacy of COX-2 Inhibitors in Periodontal Surgery: A Systematic Review and Meta-Analysis
title_short Analgesic Efficacy of COX-2 Inhibitors in Periodontal Surgery: A Systematic Review and Meta-Analysis
title_sort analgesic efficacy of cox-2 inhibitors in periodontal surgery: a systematic review and meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093797/
https://www.ncbi.nlm.nih.gov/pubmed/37046983
http://dx.doi.org/10.3390/healthcare11071054
work_keys_str_mv AT isiordiaespinozamarioalberto analgesicefficacyofcox2inhibitorsinperiodontalsurgeryasystematicreviewandmetaanalysis
AT gomezsanchezeduardo analgesicefficacyofcox2inhibitorsinperiodontalsurgeryasystematicreviewandmetaanalysis
AT morafalconitzeljoselyn analgesicefficacyofcox2inhibitorsinperiodontalsurgeryasystematicreviewandmetaanalysis
AT amadorbeasivanagustin analgesicefficacyofcox2inhibitorsinperiodontalsurgeryasystematicreviewandmetaanalysis
AT hernandezgomezadriana analgesicefficacyofcox2inhibitorsinperiodontalsurgeryasystematicreviewandmetaanalysis
AT serafinhigueranicolasaddiel analgesicefficacyofcox2inhibitorsinperiodontalsurgeryasystematicreviewandmetaanalysis
AT francodelatorrelorenzo analgesicefficacyofcox2inhibitorsinperiodontalsurgeryasystematicreviewandmetaanalysis