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The Interplay between Integrins and Immune Cells as a Regulator in Cancer Immunology

Integrins are a group of heterodimers consisting of α and β subunits that mediate a variety of physiological activities of immune cells, including cell migration, adhesion, proliferation, survival, and immunotolerance. Multiple types of integrins act differently on the same immune cells, while the s...

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Detalles Bibliográficos
Autores principales: Zhang, Qingfang, Zhang, Shuo, Chen, Jianrui, Xie, Zhenzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093897/
https://www.ncbi.nlm.nih.gov/pubmed/37047140
http://dx.doi.org/10.3390/ijms24076170
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author Zhang, Qingfang
Zhang, Shuo
Chen, Jianrui
Xie, Zhenzhen
author_facet Zhang, Qingfang
Zhang, Shuo
Chen, Jianrui
Xie, Zhenzhen
author_sort Zhang, Qingfang
collection PubMed
description Integrins are a group of heterodimers consisting of α and β subunits that mediate a variety of physiological activities of immune cells, including cell migration, adhesion, proliferation, survival, and immunotolerance. Multiple types of integrins act differently on the same immune cells, while the same integrin may exert various effects on different immune cells. In the development of cancer, integrins are involved in the regulation of cancer cell proliferation, invasion, migration, and angiogenesis; conversely, integrins promote immune cell aggregation to mediate the elimination of tumors. The important roles of integrins in cancer progression have provided valuable clues for the diagnosis and targeted treatment of cancer. Furthermore, many integrin inhibitors have been investigated in clinical trials to explore effective regimens and reduce side effects. Due to the complexity of the mechanism of integrin-mediated cancer progression, challenges remain in the research and development of cancer immunotherapies (CITs). This review enumerates the effects of integrins on four types of immune cells and the potential mechanisms involved in the progression of cancer, which will provide ideas for more optimal CIT in the future.
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spelling pubmed-100938972023-04-13 The Interplay between Integrins and Immune Cells as a Regulator in Cancer Immunology Zhang, Qingfang Zhang, Shuo Chen, Jianrui Xie, Zhenzhen Int J Mol Sci Review Integrins are a group of heterodimers consisting of α and β subunits that mediate a variety of physiological activities of immune cells, including cell migration, adhesion, proliferation, survival, and immunotolerance. Multiple types of integrins act differently on the same immune cells, while the same integrin may exert various effects on different immune cells. In the development of cancer, integrins are involved in the regulation of cancer cell proliferation, invasion, migration, and angiogenesis; conversely, integrins promote immune cell aggregation to mediate the elimination of tumors. The important roles of integrins in cancer progression have provided valuable clues for the diagnosis and targeted treatment of cancer. Furthermore, many integrin inhibitors have been investigated in clinical trials to explore effective regimens and reduce side effects. Due to the complexity of the mechanism of integrin-mediated cancer progression, challenges remain in the research and development of cancer immunotherapies (CITs). This review enumerates the effects of integrins on four types of immune cells and the potential mechanisms involved in the progression of cancer, which will provide ideas for more optimal CIT in the future. MDPI 2023-03-24 /pmc/articles/PMC10093897/ /pubmed/37047140 http://dx.doi.org/10.3390/ijms24076170 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Qingfang
Zhang, Shuo
Chen, Jianrui
Xie, Zhenzhen
The Interplay between Integrins and Immune Cells as a Regulator in Cancer Immunology
title The Interplay between Integrins and Immune Cells as a Regulator in Cancer Immunology
title_full The Interplay between Integrins and Immune Cells as a Regulator in Cancer Immunology
title_fullStr The Interplay between Integrins and Immune Cells as a Regulator in Cancer Immunology
title_full_unstemmed The Interplay between Integrins and Immune Cells as a Regulator in Cancer Immunology
title_short The Interplay between Integrins and Immune Cells as a Regulator in Cancer Immunology
title_sort interplay between integrins and immune cells as a regulator in cancer immunology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093897/
https://www.ncbi.nlm.nih.gov/pubmed/37047140
http://dx.doi.org/10.3390/ijms24076170
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