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Recent Insight into the Role of Sphingosine-1-Phosphate Lyase in Neurodegeneration
Sphingosine-1-phosphate lyase (SPL) is a pyridoxal 5′-phosphate-dependent enzyme involved in the irreversible degradation of sphingosine-1-phosphate (S1P)—a bioactive sphingolipid that modulates a broad range of biological processes (cell proliferation, migration, differentiation and survival; mitoc...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093903/ https://www.ncbi.nlm.nih.gov/pubmed/37047151 http://dx.doi.org/10.3390/ijms24076180 |
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author | Wieczorek, Iga Strosznajder, Robert Piotr |
author_facet | Wieczorek, Iga Strosznajder, Robert Piotr |
author_sort | Wieczorek, Iga |
collection | PubMed |
description | Sphingosine-1-phosphate lyase (SPL) is a pyridoxal 5′-phosphate-dependent enzyme involved in the irreversible degradation of sphingosine-1-phosphate (S1P)—a bioactive sphingolipid that modulates a broad range of biological processes (cell proliferation, migration, differentiation and survival; mitochondrial functioning; and gene expression). Although SPL activity leads to a decrease in the available pool of S1P in the cell, at the same time, hexadecenal and phosphoethanolamine, compounds with potential biological activity, are generated. The increased expression and/or activity of SPL, and hence the imbalance between S1P and the end products of its cleavage, were demonstrated in several pathological states. On the other hand, loss-of-function mutations in the SPL encoding gene are a cause of severe developmental impairments. Recently, special attention has been paid to neurodegenerative diseases as the most common pathologies of the nervous system. This review summarizes the current findings concerning the role of SPL in the nervous system with an emphasis on neurodegeneration. Moreover, it briefly discusses pharmacological compounds directed to inhibit its activity. |
format | Online Article Text |
id | pubmed-10093903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100939032023-04-13 Recent Insight into the Role of Sphingosine-1-Phosphate Lyase in Neurodegeneration Wieczorek, Iga Strosznajder, Robert Piotr Int J Mol Sci Review Sphingosine-1-phosphate lyase (SPL) is a pyridoxal 5′-phosphate-dependent enzyme involved in the irreversible degradation of sphingosine-1-phosphate (S1P)—a bioactive sphingolipid that modulates a broad range of biological processes (cell proliferation, migration, differentiation and survival; mitochondrial functioning; and gene expression). Although SPL activity leads to a decrease in the available pool of S1P in the cell, at the same time, hexadecenal and phosphoethanolamine, compounds with potential biological activity, are generated. The increased expression and/or activity of SPL, and hence the imbalance between S1P and the end products of its cleavage, were demonstrated in several pathological states. On the other hand, loss-of-function mutations in the SPL encoding gene are a cause of severe developmental impairments. Recently, special attention has been paid to neurodegenerative diseases as the most common pathologies of the nervous system. This review summarizes the current findings concerning the role of SPL in the nervous system with an emphasis on neurodegeneration. Moreover, it briefly discusses pharmacological compounds directed to inhibit its activity. MDPI 2023-03-24 /pmc/articles/PMC10093903/ /pubmed/37047151 http://dx.doi.org/10.3390/ijms24076180 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wieczorek, Iga Strosznajder, Robert Piotr Recent Insight into the Role of Sphingosine-1-Phosphate Lyase in Neurodegeneration |
title | Recent Insight into the Role of Sphingosine-1-Phosphate Lyase in Neurodegeneration |
title_full | Recent Insight into the Role of Sphingosine-1-Phosphate Lyase in Neurodegeneration |
title_fullStr | Recent Insight into the Role of Sphingosine-1-Phosphate Lyase in Neurodegeneration |
title_full_unstemmed | Recent Insight into the Role of Sphingosine-1-Phosphate Lyase in Neurodegeneration |
title_short | Recent Insight into the Role of Sphingosine-1-Phosphate Lyase in Neurodegeneration |
title_sort | recent insight into the role of sphingosine-1-phosphate lyase in neurodegeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093903/ https://www.ncbi.nlm.nih.gov/pubmed/37047151 http://dx.doi.org/10.3390/ijms24076180 |
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