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Voluntary Exercise to Reduce Anxiety Behaviour in Traumatic Brain Injury Shown to Alleviate Inflammatory Brain Response in Mice

Traumatic brain injury is a leading cause of neuroinflammation and anxiety disorders in young adults. Immune-targeted therapies have garnered attention for the amelioration of TBI-induced anxiety. A previous study has indicated that voluntary exercise intervention following TBI could reduce neuroinf...

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Autores principales: Hu, Xiaoxuan, Ou, Yuhang, Li, Jiashuo, Sun, Meiqi, Ge, Qian, Pan, Yongqi, Cai, Zhenlu, Tan, Ruolan, Wang, Wenyu, An, Jing, Lu, Haixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093932/
https://www.ncbi.nlm.nih.gov/pubmed/37047351
http://dx.doi.org/10.3390/ijms24076365
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author Hu, Xiaoxuan
Ou, Yuhang
Li, Jiashuo
Sun, Meiqi
Ge, Qian
Pan, Yongqi
Cai, Zhenlu
Tan, Ruolan
Wang, Wenyu
An, Jing
Lu, Haixia
author_facet Hu, Xiaoxuan
Ou, Yuhang
Li, Jiashuo
Sun, Meiqi
Ge, Qian
Pan, Yongqi
Cai, Zhenlu
Tan, Ruolan
Wang, Wenyu
An, Jing
Lu, Haixia
author_sort Hu, Xiaoxuan
collection PubMed
description Traumatic brain injury is a leading cause of neuroinflammation and anxiety disorders in young adults. Immune-targeted therapies have garnered attention for the amelioration of TBI-induced anxiety. A previous study has indicated that voluntary exercise intervention following TBI could reduce neuroinflammation. It is essential to determine the effects of voluntary exercise after TBI on anxiety via inhibiting neuroinflammatory response. Mice were randomly divided into four groups (sham, TBI, sham + voluntary wheel running (VWR), and TBI + VWR). One-week VWR was carried out on the 2nd day after trauma. The neurofunction of TBI mice was assessed. Following VWR, anxiety behavior was evaluated, and neuroinflammatory responses in the perilesional cortex were investigated. Results showed that after one week of VWR, neurofunctional recovery was enhanced, while the anxiety behavior of TBI mice was significantly alleviated. The level of pro-inflammatory factors decreased, and the level of anti-inflammatory factors elevated. Activation of nucleotide oligomerization domain-like thermal receptor protein domain associated protein 3 (NLRP3) inflammasome was inhibited significantly. All these alterations were consistent with reduced microglial activation at the perilesional site and positively correlated with the amelioration of anxiety behavior. This suggested that timely rehabilitative exercise could be a useful therapeutic strategy for anxiety resulting from TBI by targeting neuroinflammation.
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spelling pubmed-100939322023-04-13 Voluntary Exercise to Reduce Anxiety Behaviour in Traumatic Brain Injury Shown to Alleviate Inflammatory Brain Response in Mice Hu, Xiaoxuan Ou, Yuhang Li, Jiashuo Sun, Meiqi Ge, Qian Pan, Yongqi Cai, Zhenlu Tan, Ruolan Wang, Wenyu An, Jing Lu, Haixia Int J Mol Sci Article Traumatic brain injury is a leading cause of neuroinflammation and anxiety disorders in young adults. Immune-targeted therapies have garnered attention for the amelioration of TBI-induced anxiety. A previous study has indicated that voluntary exercise intervention following TBI could reduce neuroinflammation. It is essential to determine the effects of voluntary exercise after TBI on anxiety via inhibiting neuroinflammatory response. Mice were randomly divided into four groups (sham, TBI, sham + voluntary wheel running (VWR), and TBI + VWR). One-week VWR was carried out on the 2nd day after trauma. The neurofunction of TBI mice was assessed. Following VWR, anxiety behavior was evaluated, and neuroinflammatory responses in the perilesional cortex were investigated. Results showed that after one week of VWR, neurofunctional recovery was enhanced, while the anxiety behavior of TBI mice was significantly alleviated. The level of pro-inflammatory factors decreased, and the level of anti-inflammatory factors elevated. Activation of nucleotide oligomerization domain-like thermal receptor protein domain associated protein 3 (NLRP3) inflammasome was inhibited significantly. All these alterations were consistent with reduced microglial activation at the perilesional site and positively correlated with the amelioration of anxiety behavior. This suggested that timely rehabilitative exercise could be a useful therapeutic strategy for anxiety resulting from TBI by targeting neuroinflammation. MDPI 2023-03-28 /pmc/articles/PMC10093932/ /pubmed/37047351 http://dx.doi.org/10.3390/ijms24076365 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hu, Xiaoxuan
Ou, Yuhang
Li, Jiashuo
Sun, Meiqi
Ge, Qian
Pan, Yongqi
Cai, Zhenlu
Tan, Ruolan
Wang, Wenyu
An, Jing
Lu, Haixia
Voluntary Exercise to Reduce Anxiety Behaviour in Traumatic Brain Injury Shown to Alleviate Inflammatory Brain Response in Mice
title Voluntary Exercise to Reduce Anxiety Behaviour in Traumatic Brain Injury Shown to Alleviate Inflammatory Brain Response in Mice
title_full Voluntary Exercise to Reduce Anxiety Behaviour in Traumatic Brain Injury Shown to Alleviate Inflammatory Brain Response in Mice
title_fullStr Voluntary Exercise to Reduce Anxiety Behaviour in Traumatic Brain Injury Shown to Alleviate Inflammatory Brain Response in Mice
title_full_unstemmed Voluntary Exercise to Reduce Anxiety Behaviour in Traumatic Brain Injury Shown to Alleviate Inflammatory Brain Response in Mice
title_short Voluntary Exercise to Reduce Anxiety Behaviour in Traumatic Brain Injury Shown to Alleviate Inflammatory Brain Response in Mice
title_sort voluntary exercise to reduce anxiety behaviour in traumatic brain injury shown to alleviate inflammatory brain response in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093932/
https://www.ncbi.nlm.nih.gov/pubmed/37047351
http://dx.doi.org/10.3390/ijms24076365
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