An orthogonally activatable CRISPR-Cas13d nanoprodrug to reverse chemoresistance for enhanced chemo-photodynamic therapy

Orthogonal therapy that combines CRISPR-based gene editing and prodrug-based chemotherapy is a promising approach to combat multidrug-resistant cancer. However, its potency to precisely regulate different therapeutic modalities in vivo is limited due to the lack of an integrated platform with high s...

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Detalles Bibliográficos
Autores principales: Liu, Zheng, Feng, Zhiyuan, Chen, Mohan, Zhan, Jiayin, Wu, Rong, Shi, Yang, Xue, Yunsheng, Liu, Ran, Zhu, Jun-Jie, Zhang, Jingjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094006/
https://www.ncbi.nlm.nih.gov/pubmed/37063792
http://dx.doi.org/10.1039/d3sc00020f

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