Cargando…

Novel Insights in the Potential of Halogenated Polyketide–Peptide Molecules as Lead Compounds in Cancer Drug Discovery

In this interdisciplinary study, we selected two compounds, namely, smenamide A, a peptide–polyketide, and smenolactone D, a polyketide, as models because they are representative of two different classes of molecules isolated from the marine sponge Smenospongia aurea. The organic extract of Smenospo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pellicioni, Valentina, Esposito, Germana, Greco, Giulia, Cruz-Chamorro, Ivan, Ferrini, Fabio, Sestili, Piero, Teta, Roberta, Fimognari, Carmela, Costantino, Valeria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094022/ https://www.ncbi.nlm.nih.gov/pubmed/37047184 http://dx.doi.org/10.3390/ijms24076208

Ejemplares similares

Discovery of Sulforaphane as an Inducer of Ferroptosis in U-937 Leukemia Cells: Expanding Its Anticancer Potential
por: Greco, Giulia, et al.
Publicado: (2021)

Marine-Derived Compounds Targeting Topoisomerase II in Cancer Cells: A Review
por: Greco, Giulia, et al.
Publicado: (2022)

The Anti- and Pro-Tumorigenic Role of Microbiota and Its Role in Anticancer Therapeutic Strategies
por: Greco, Giulia, et al.
Publicado: (2022)

Isolation and Assessment of the in Vitro Anti-Tumor Activity of Smenothiazole A and B, Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge, Smenospongia aurea
por: Esposito, Germana, et al.
Publicado: (2015)

Polyketide Synthases in the Microbiome of the Marine Sponge Plakortis halichondrioides: A Metagenomic Update
por: Della Sala, Gerardo, et al.
Publicado: (2014)

Cytotoxic and Antitumor Activity of Sulforaphane: The Role of Reactive Oxygen Species
por: Sestili, Piero, et al.
Publicado: (2015)

Paracetamol-Induced Glutathione Consumption: Is There a Link With Severe COVID-19 Illness?
por: Sestili, Piero, et al.
Publicado: (2020)

Polyketide genes in the marine sponge Plakortis simplex: a new group of mono-modular type I polyketide synthases from sponge symbionts
por: Della Sala, Gerardo, et al.
Publicado: (2013)

Smenamides A and B, Chlorinated Peptide/Polyketide Hybrids Containing a Dolapyrrolidinone Unit from the Caribbean Sponge Smenospongia aurea. Evaluation of Their Role as Leads in Antitumor Drug Research
por: Teta, Roberta, et al.
Publicado: (2013)

Effect of the Marine Polyketide Plocabulin on Tumor Progression
por: Turrini, Eleonora, et al.
Publicado: (2022)

Exploring Chemical Diversity of Phorbas Sponges as a Source of Novel Lead Compounds in Drug Discovery
por: Caso, Alessia, et al.
Publicado: (2021)

A Four-Step Platform to Optimize Growth Conditions for High-Yield Production of Siderophores in Cyanobacteria
por: Kundu, Karishma, et al.
Publicado: (2023)

Overview of the Anticancer Potential of the “King of Spices” Piper nigrum and Its Main Constituent Piperine
por: Turrini, Eleonora, et al.
Publicado: (2020)

Spirotetronate Polyketides as Leads in Drug Discovery
por: Lacoske, Michelle H., et al.
Publicado: (2014)

Editorial: Peptide/Polyketide Molecules From Marine Macro and/or Microorganisms
por: Costantino, Valeria, et al.
Publicado: (2020)

Isolation of Smenopyrone, a Bis-γ-Pyrone Polypropionate from the Caribbean Sponge Smenospongia aurea
por: Esposito, Germana, et al.
Publicado: (2018)

Zeamide, a Glycosylinositol Phosphorylceramide with the Novel Core Arap(1β→6)Ins Motif from the Marine Sponge Svenzea zeai
por: Della Sala, Gerardo, et al.
Publicado: (2017)

A Glimpse at Siderophores Production by Anabaena flos-aquae UTEX 1444
por: Teta, Roberta, et al.
Publicado: (2022)

Janus Kinase Inhibitors and Coronavirus Disease (COVID)-19: Rationale, Clinical Evidence and Safety Issues
por: Gatti, Milo, et al.
Publicado: (2021)

Fast Detection of Two Smenamide Family Members Using Molecular Networking
por: Caso, Alessia, et al.
Publicado: (2019)

Identification of the Biosynthetic Gene Cluster of Thermoactinoamides and Discovery of New Congeners by Integrated Genome Mining and MS-Based Molecular Networking
por: Della Sala, Gerardo, et al.
Publicado: (2020)

A Biomimetic Polyketide-Inspired Approach to Small Molecule Ligand Discovery
por: Aquino, Claudio, et al.
Publicado: (2011)

Characterization of the Biological Activity of the Ethanolic Extract from the Roots of Cannabis sativa L. Grown in Aeroponics
por: Ferrini, Fabio, et al.
Publicado: (2022)

Hemidesmus indicus induces apoptosis via proteasome inhibition and generation of reactive oxygen species
por: Turrini, Eleonora, et al.
Publicado: (2019)

Monitoring Cyanobacterial Blooms during the COVID-19 Pandemic in Campania, Italy: The Case of Lake Avernus
por: Teta, Roberta, et al.
Publicado: (2021)

Natural Products as Inducers of Non-Canonical Cell Death: A Weapon against Cancer
por: Greco, Giulia, et al.
Publicado: (2021)

Synthesis and Biological Evaluation of New Bis-Indolinone Derivatives Endowed with Cytotoxic Activity
por: Morigi, Rita, et al.
Publicado: (2021)

Sulforaphane Potentiates RNA Damage Induced by Different Xenobiotics
por: Fimognari, Carmela, et al.
Publicado: (2012)

Correction: Sulforaphane Potentiates RNA Damage Induced by Different Xenobiotics
por: Fimognari, Carmela, et al.
Publicado: (2012)

Antileukemic Activity of Sulforaphane in Primary Blasts from Patients Affected by Myelo- and Lympho-Proliferative Disorders and in Hypoxic Conditions
por: Fimognari, Carmela, et al.
Publicado: (2014)

Identification of Quorum Sensing Activators and Inhibitors in The Marine Sponge Sarcotragus spinosulus
por: Saurav, Kumar, et al.
Publicado: (2020)

Computational Metabolomics Tools Reveal Subarmigerides, Unprecedented Linear Peptides from the Marine Sponge Holobiont Callyspongia subarmigera
por: Castaldi, Andrea, et al.
Publicado: (2022)

Marine Anthraquinones: Pharmacological and Toxicological Issues
por: Greco, Giulia, et al.
Publicado: (2021)

Ellagitannins in Cancer Chemoprevention and Therapy
por: Ismail, Tariq, et al.
Publicado: (2016)

Deuterium Incorporation Protects Cells from Oxidative Damage
por: Sestili, Piero, et al.
Publicado: (2019)

In Vitro Investigation of the Anticancer Properties of Ammodaucus Leucotrichus Coss. & Dur.
por: Lenzi, Monia, et al.
Publicado: (2022)

Natural Products to Fight Cancer: A Focus on Juglans regia
por: Catanzaro, Elena, et al.
Publicado: (2018)

In Silico/In Vitro Strategies Leading to the Discovery of New Nonribosomal Peptide and Polyketide Antibiotics Active against Human Pathogens
por: Khabthani, Sami, et al.
Publicado: (2021)

Overexpression of Global Regulator PbrlaeA Leads to the Discovery of New Polyketide in Fungus Penicillium Brocae HDN-12-143
por: Wang, Lu, et al.
Publicado: (2020)

Overexpression of Global Regulator Talae1 Leads to the Discovery of New Antifungal Polyketides From Endophytic Fungus Trichoderma afroharzianum
por: Ding, Zhuang, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_5vddijc7rouibhmnpla9e1ob5s