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Primary Cutaneous B-Cell Lymphomas with Large Cell Morphology: A Practical Review
Most primary cutaneous lymphomas consist of T-cell lymphomas or small cell lymphomas; however, the skin may also be affected by lymphomas with large cell morphology, as a primary or secondary localization. A minority of cases consist of primary cutaneous B-cell lymphomas (PCBCLs). PCBCLs are a heter...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094092/ https://www.ncbi.nlm.nih.gov/pubmed/37047176 http://dx.doi.org/10.3390/ijms24076204 |
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author | Ronchi, Andrea Vitiello, Paola D’Abbronzo, Giuseppe Caccavale, Stefano Argenziano, Giuseppe Sica, Antonello Alfano, Roberto Savarese, Giovanni Berretta, Massimiliano Cozzolino, Immacolata Franco, Renato |
author_facet | Ronchi, Andrea Vitiello, Paola D’Abbronzo, Giuseppe Caccavale, Stefano Argenziano, Giuseppe Sica, Antonello Alfano, Roberto Savarese, Giovanni Berretta, Massimiliano Cozzolino, Immacolata Franco, Renato |
author_sort | Ronchi, Andrea |
collection | PubMed |
description | Most primary cutaneous lymphomas consist of T-cell lymphomas or small cell lymphomas; however, the skin may also be affected by lymphomas with large cell morphology, as a primary or secondary localization. A minority of cases consist of primary cutaneous B-cell lymphomas (PCBCLs). PCBCLs are a heterogeneous group of rare neoplasms with an overlapping morphological and immunohistochemical picture of the different subtypes. Nevertheless, differential diagnosis in the setting of this group of neoplasms is mandatory to identify the correct therapy and prognosis, but it may be challenging since, due to the rarity of these neoplasms, they may not always be familiar to pathologists. Indeed, immunohistochemistry may not be enough to distinguish the different histotypes, which overlap in immunohistochemical features. Furthermore, the ever-increasing knowledge of the molecular features of systemic B-cell lymphomas, such as gene rearrangements with clinical significance, has led in recent years to further investigation into the molecular landscape of PCBCLs with large cell morphology. This work aimed to provide a practical diagnostic guide for pathologists dealing with primary cutaneous large B-cell lymphomas. |
format | Online Article Text |
id | pubmed-10094092 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100940922023-04-13 Primary Cutaneous B-Cell Lymphomas with Large Cell Morphology: A Practical Review Ronchi, Andrea Vitiello, Paola D’Abbronzo, Giuseppe Caccavale, Stefano Argenziano, Giuseppe Sica, Antonello Alfano, Roberto Savarese, Giovanni Berretta, Massimiliano Cozzolino, Immacolata Franco, Renato Int J Mol Sci Review Most primary cutaneous lymphomas consist of T-cell lymphomas or small cell lymphomas; however, the skin may also be affected by lymphomas with large cell morphology, as a primary or secondary localization. A minority of cases consist of primary cutaneous B-cell lymphomas (PCBCLs). PCBCLs are a heterogeneous group of rare neoplasms with an overlapping morphological and immunohistochemical picture of the different subtypes. Nevertheless, differential diagnosis in the setting of this group of neoplasms is mandatory to identify the correct therapy and prognosis, but it may be challenging since, due to the rarity of these neoplasms, they may not always be familiar to pathologists. Indeed, immunohistochemistry may not be enough to distinguish the different histotypes, which overlap in immunohistochemical features. Furthermore, the ever-increasing knowledge of the molecular features of systemic B-cell lymphomas, such as gene rearrangements with clinical significance, has led in recent years to further investigation into the molecular landscape of PCBCLs with large cell morphology. This work aimed to provide a practical diagnostic guide for pathologists dealing with primary cutaneous large B-cell lymphomas. MDPI 2023-03-25 /pmc/articles/PMC10094092/ /pubmed/37047176 http://dx.doi.org/10.3390/ijms24076204 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ronchi, Andrea Vitiello, Paola D’Abbronzo, Giuseppe Caccavale, Stefano Argenziano, Giuseppe Sica, Antonello Alfano, Roberto Savarese, Giovanni Berretta, Massimiliano Cozzolino, Immacolata Franco, Renato Primary Cutaneous B-Cell Lymphomas with Large Cell Morphology: A Practical Review |
title | Primary Cutaneous B-Cell Lymphomas with Large Cell Morphology: A Practical Review |
title_full | Primary Cutaneous B-Cell Lymphomas with Large Cell Morphology: A Practical Review |
title_fullStr | Primary Cutaneous B-Cell Lymphomas with Large Cell Morphology: A Practical Review |
title_full_unstemmed | Primary Cutaneous B-Cell Lymphomas with Large Cell Morphology: A Practical Review |
title_short | Primary Cutaneous B-Cell Lymphomas with Large Cell Morphology: A Practical Review |
title_sort | primary cutaneous b-cell lymphomas with large cell morphology: a practical review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094092/ https://www.ncbi.nlm.nih.gov/pubmed/37047176 http://dx.doi.org/10.3390/ijms24076204 |
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