Cargando…

Distinct Predictors of Clinical Response after Repetitive Transcranial Magnetic Stimulation between Bipolar and Unipolar Disorders

Background: Repetitive transcranial magnetic stimulation (rTMS) has been shown to be therapeutically effective for patients suffering from drug-resistant depression. The distinction between bipolar and unipolar disorders would be of great interests to better adapt their respective treatments. Method...

Descripción completa

Detalles Bibliográficos
Autores principales: Lacroix, Aurélie, Paquet, Aude, Okassa, Mireille, Vinais, Théodore, Lannaud, Marilyne, Plansont, Brigitte, Buisson, Alexandre, Guignandon, Sandrine, Malauzat, Dominique, Girard, Murielle, Calvet, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094223/
https://www.ncbi.nlm.nih.gov/pubmed/37047892
http://dx.doi.org/10.3390/ijerph20075276
_version_ 1785023787587076096
author Lacroix, Aurélie
Paquet, Aude
Okassa, Mireille
Vinais, Théodore
Lannaud, Marilyne
Plansont, Brigitte
Buisson, Alexandre
Guignandon, Sandrine
Malauzat, Dominique
Girard, Murielle
Calvet, Benjamin
author_facet Lacroix, Aurélie
Paquet, Aude
Okassa, Mireille
Vinais, Théodore
Lannaud, Marilyne
Plansont, Brigitte
Buisson, Alexandre
Guignandon, Sandrine
Malauzat, Dominique
Girard, Murielle
Calvet, Benjamin
author_sort Lacroix, Aurélie
collection PubMed
description Background: Repetitive transcranial magnetic stimulation (rTMS) has been shown to be therapeutically effective for patients suffering from drug-resistant depression. The distinction between bipolar and unipolar disorders would be of great interests to better adapt their respective treatments. Methods: We aimed to identify the factors predicting clinical improvement at one month (M1) after the start of rTMS treatment for each diagnosis, which was preceded by a comparison of the patients’ clinical conditions. We used the data collected and the method employed in a previous publication on 291 patients. Results: Although the bipolar group had fewer responders, these patients seemed to better maintain their post-rTMS improvement on anxiety and perception of the severity of their illness than those in the unipolar group. For the bipolar group, young age coupled with low number of medications and high fatigue was shown to be the best combination for predicting improvement at M1. The duration of current depressive episode, which was previously demonstrated for whole group, combined with being attached was shown to favor clinical improvement among the patients in unipolar group. Conclusion: We were able to define a combination of specific factors related to each diagnosis for predicting the patients’ clinical response. This could be extremely useful to predict the efficacy of rTMS during routine clinical practice in neuromodulation services.
format Online
Article
Text
id pubmed-10094223
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100942232023-04-13 Distinct Predictors of Clinical Response after Repetitive Transcranial Magnetic Stimulation between Bipolar and Unipolar Disorders Lacroix, Aurélie Paquet, Aude Okassa, Mireille Vinais, Théodore Lannaud, Marilyne Plansont, Brigitte Buisson, Alexandre Guignandon, Sandrine Malauzat, Dominique Girard, Murielle Calvet, Benjamin Int J Environ Res Public Health Article Background: Repetitive transcranial magnetic stimulation (rTMS) has been shown to be therapeutically effective for patients suffering from drug-resistant depression. The distinction between bipolar and unipolar disorders would be of great interests to better adapt their respective treatments. Methods: We aimed to identify the factors predicting clinical improvement at one month (M1) after the start of rTMS treatment for each diagnosis, which was preceded by a comparison of the patients’ clinical conditions. We used the data collected and the method employed in a previous publication on 291 patients. Results: Although the bipolar group had fewer responders, these patients seemed to better maintain their post-rTMS improvement on anxiety and perception of the severity of their illness than those in the unipolar group. For the bipolar group, young age coupled with low number of medications and high fatigue was shown to be the best combination for predicting improvement at M1. The duration of current depressive episode, which was previously demonstrated for whole group, combined with being attached was shown to favor clinical improvement among the patients in unipolar group. Conclusion: We were able to define a combination of specific factors related to each diagnosis for predicting the patients’ clinical response. This could be extremely useful to predict the efficacy of rTMS during routine clinical practice in neuromodulation services. MDPI 2023-03-27 /pmc/articles/PMC10094223/ /pubmed/37047892 http://dx.doi.org/10.3390/ijerph20075276 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lacroix, Aurélie
Paquet, Aude
Okassa, Mireille
Vinais, Théodore
Lannaud, Marilyne
Plansont, Brigitte
Buisson, Alexandre
Guignandon, Sandrine
Malauzat, Dominique
Girard, Murielle
Calvet, Benjamin
Distinct Predictors of Clinical Response after Repetitive Transcranial Magnetic Stimulation between Bipolar and Unipolar Disorders
title Distinct Predictors of Clinical Response after Repetitive Transcranial Magnetic Stimulation between Bipolar and Unipolar Disorders
title_full Distinct Predictors of Clinical Response after Repetitive Transcranial Magnetic Stimulation between Bipolar and Unipolar Disorders
title_fullStr Distinct Predictors of Clinical Response after Repetitive Transcranial Magnetic Stimulation between Bipolar and Unipolar Disorders
title_full_unstemmed Distinct Predictors of Clinical Response after Repetitive Transcranial Magnetic Stimulation between Bipolar and Unipolar Disorders
title_short Distinct Predictors of Clinical Response after Repetitive Transcranial Magnetic Stimulation between Bipolar and Unipolar Disorders
title_sort distinct predictors of clinical response after repetitive transcranial magnetic stimulation between bipolar and unipolar disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094223/
https://www.ncbi.nlm.nih.gov/pubmed/37047892
http://dx.doi.org/10.3390/ijerph20075276
work_keys_str_mv AT lacroixaurelie distinctpredictorsofclinicalresponseafterrepetitivetranscranialmagneticstimulationbetweenbipolarandunipolardisorders
AT paquetaude distinctpredictorsofclinicalresponseafterrepetitivetranscranialmagneticstimulationbetweenbipolarandunipolardisorders
AT okassamireille distinctpredictorsofclinicalresponseafterrepetitivetranscranialmagneticstimulationbetweenbipolarandunipolardisorders
AT vinaistheodore distinctpredictorsofclinicalresponseafterrepetitivetranscranialmagneticstimulationbetweenbipolarandunipolardisorders
AT lannaudmarilyne distinctpredictorsofclinicalresponseafterrepetitivetranscranialmagneticstimulationbetweenbipolarandunipolardisorders
AT plansontbrigitte distinctpredictorsofclinicalresponseafterrepetitivetranscranialmagneticstimulationbetweenbipolarandunipolardisorders
AT buissonalexandre distinctpredictorsofclinicalresponseafterrepetitivetranscranialmagneticstimulationbetweenbipolarandunipolardisorders
AT guignandonsandrine distinctpredictorsofclinicalresponseafterrepetitivetranscranialmagneticstimulationbetweenbipolarandunipolardisorders
AT malauzatdominique distinctpredictorsofclinicalresponseafterrepetitivetranscranialmagneticstimulationbetweenbipolarandunipolardisorders
AT girardmurielle distinctpredictorsofclinicalresponseafterrepetitivetranscranialmagneticstimulationbetweenbipolarandunipolardisorders
AT calvetbenjamin distinctpredictorsofclinicalresponseafterrepetitivetranscranialmagneticstimulationbetweenbipolarandunipolardisorders