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Distinct Predictors of Clinical Response after Repetitive Transcranial Magnetic Stimulation between Bipolar and Unipolar Disorders
Background: Repetitive transcranial magnetic stimulation (rTMS) has been shown to be therapeutically effective for patients suffering from drug-resistant depression. The distinction between bipolar and unipolar disorders would be of great interests to better adapt their respective treatments. Method...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094223/ https://www.ncbi.nlm.nih.gov/pubmed/37047892 http://dx.doi.org/10.3390/ijerph20075276 |
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author | Lacroix, Aurélie Paquet, Aude Okassa, Mireille Vinais, Théodore Lannaud, Marilyne Plansont, Brigitte Buisson, Alexandre Guignandon, Sandrine Malauzat, Dominique Girard, Murielle Calvet, Benjamin |
author_facet | Lacroix, Aurélie Paquet, Aude Okassa, Mireille Vinais, Théodore Lannaud, Marilyne Plansont, Brigitte Buisson, Alexandre Guignandon, Sandrine Malauzat, Dominique Girard, Murielle Calvet, Benjamin |
author_sort | Lacroix, Aurélie |
collection | PubMed |
description | Background: Repetitive transcranial magnetic stimulation (rTMS) has been shown to be therapeutically effective for patients suffering from drug-resistant depression. The distinction between bipolar and unipolar disorders would be of great interests to better adapt their respective treatments. Methods: We aimed to identify the factors predicting clinical improvement at one month (M1) after the start of rTMS treatment for each diagnosis, which was preceded by a comparison of the patients’ clinical conditions. We used the data collected and the method employed in a previous publication on 291 patients. Results: Although the bipolar group had fewer responders, these patients seemed to better maintain their post-rTMS improvement on anxiety and perception of the severity of their illness than those in the unipolar group. For the bipolar group, young age coupled with low number of medications and high fatigue was shown to be the best combination for predicting improvement at M1. The duration of current depressive episode, which was previously demonstrated for whole group, combined with being attached was shown to favor clinical improvement among the patients in unipolar group. Conclusion: We were able to define a combination of specific factors related to each diagnosis for predicting the patients’ clinical response. This could be extremely useful to predict the efficacy of rTMS during routine clinical practice in neuromodulation services. |
format | Online Article Text |
id | pubmed-10094223 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100942232023-04-13 Distinct Predictors of Clinical Response after Repetitive Transcranial Magnetic Stimulation between Bipolar and Unipolar Disorders Lacroix, Aurélie Paquet, Aude Okassa, Mireille Vinais, Théodore Lannaud, Marilyne Plansont, Brigitte Buisson, Alexandre Guignandon, Sandrine Malauzat, Dominique Girard, Murielle Calvet, Benjamin Int J Environ Res Public Health Article Background: Repetitive transcranial magnetic stimulation (rTMS) has been shown to be therapeutically effective for patients suffering from drug-resistant depression. The distinction between bipolar and unipolar disorders would be of great interests to better adapt their respective treatments. Methods: We aimed to identify the factors predicting clinical improvement at one month (M1) after the start of rTMS treatment for each diagnosis, which was preceded by a comparison of the patients’ clinical conditions. We used the data collected and the method employed in a previous publication on 291 patients. Results: Although the bipolar group had fewer responders, these patients seemed to better maintain their post-rTMS improvement on anxiety and perception of the severity of their illness than those in the unipolar group. For the bipolar group, young age coupled with low number of medications and high fatigue was shown to be the best combination for predicting improvement at M1. The duration of current depressive episode, which was previously demonstrated for whole group, combined with being attached was shown to favor clinical improvement among the patients in unipolar group. Conclusion: We were able to define a combination of specific factors related to each diagnosis for predicting the patients’ clinical response. This could be extremely useful to predict the efficacy of rTMS during routine clinical practice in neuromodulation services. MDPI 2023-03-27 /pmc/articles/PMC10094223/ /pubmed/37047892 http://dx.doi.org/10.3390/ijerph20075276 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lacroix, Aurélie Paquet, Aude Okassa, Mireille Vinais, Théodore Lannaud, Marilyne Plansont, Brigitte Buisson, Alexandre Guignandon, Sandrine Malauzat, Dominique Girard, Murielle Calvet, Benjamin Distinct Predictors of Clinical Response after Repetitive Transcranial Magnetic Stimulation between Bipolar and Unipolar Disorders |
title | Distinct Predictors of Clinical Response after Repetitive Transcranial Magnetic Stimulation between Bipolar and Unipolar Disorders |
title_full | Distinct Predictors of Clinical Response after Repetitive Transcranial Magnetic Stimulation between Bipolar and Unipolar Disorders |
title_fullStr | Distinct Predictors of Clinical Response after Repetitive Transcranial Magnetic Stimulation between Bipolar and Unipolar Disorders |
title_full_unstemmed | Distinct Predictors of Clinical Response after Repetitive Transcranial Magnetic Stimulation between Bipolar and Unipolar Disorders |
title_short | Distinct Predictors of Clinical Response after Repetitive Transcranial Magnetic Stimulation between Bipolar and Unipolar Disorders |
title_sort | distinct predictors of clinical response after repetitive transcranial magnetic stimulation between bipolar and unipolar disorders |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094223/ https://www.ncbi.nlm.nih.gov/pubmed/37047892 http://dx.doi.org/10.3390/ijerph20075276 |
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