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Mutational and Environmental Effects on the Dynamic Conformational Distributions of Lys48-Linked Ubiquitin Chains

In multidomain proteins, individual domains connected by flexible linkers are dynamically rearranged upon ligand binding and sensing changes in environmental factors, such as pH and temperature. Here, we characterize dynamic domain rearrangements of Lys48-linked ubiquitin (Ub) chains as models of mu...

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Detalles Bibliográficos
Autores principales:	Hiranyakorn, Methanee, Yagi-Utsumi, Maho, Yanaka, Saeko, Ohtsuka, Naoya, Momiyama, Norie, Satoh, Tadashi, Kato, Koichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094362/ https://www.ncbi.nlm.nih.gov/pubmed/37047047 http://dx.doi.org/10.3390/ijms24076075

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