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Blood Cell Biomarkers of Inflammation and Cytokine Levels as Predictors of Response to Biologics in Patients with Psoriasis

For people with psoriasis, biomarkers aiding in the personalization of treatment with biologics are needed. We examined the usefulness of several biomarkers of inflammation in this respect. The neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the systemic immune–infl...

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Autores principales: Andersen, Clara Sophie Bramsen, Kvist-Hansen, Amanda, Siewertsen, Mie, Enevold, Christian, Hansen, Peter Riis, Kaur-Knudsen, Diljit, Zachariae, Claus, Nielsen, Claus Henrik, Loft, Nikolai, Skov, Lone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094459/
https://www.ncbi.nlm.nih.gov/pubmed/37047086
http://dx.doi.org/10.3390/ijms24076111
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author Andersen, Clara Sophie Bramsen
Kvist-Hansen, Amanda
Siewertsen, Mie
Enevold, Christian
Hansen, Peter Riis
Kaur-Knudsen, Diljit
Zachariae, Claus
Nielsen, Claus Henrik
Loft, Nikolai
Skov, Lone
author_facet Andersen, Clara Sophie Bramsen
Kvist-Hansen, Amanda
Siewertsen, Mie
Enevold, Christian
Hansen, Peter Riis
Kaur-Knudsen, Diljit
Zachariae, Claus
Nielsen, Claus Henrik
Loft, Nikolai
Skov, Lone
author_sort Andersen, Clara Sophie Bramsen
collection PubMed
description For people with psoriasis, biomarkers aiding in the personalization of treatment with biologics are needed. We examined the usefulness of several biomarkers of inflammation in this respect. The neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the systemic immune–inflammation index (SII) were measured in patients with psoriasis initiating TNF-α inhibitors (n = 131), IL-17/IL-17R inhibitors (n = 65), or IL-23/IL-12/23 inhibitors (n = 50). The blood levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, interferon (IFN)-γ, IL-17A, IL-6, soluble IL-6 receptor (sIL-6R), and soluble IL-6 signal transducer (sIL-6ST) were measured in patients initiating adalimumab (n = 62) or IL-17/IL-17R inhibitors (n = 24). Treatment response was defined by a psoriasis area and severity index (PASI) ≤ 2 three months after treatment initiation. Responders to TNF-α inhibitors had a lower NLR at baseline than non-responders (median and interquartile range (IQR) 2.15 (1.67–2.86) vs. 2.54 (1.88–3.55); p = 0.04). Responders to treatment with adalimumab had lower IL-6 levels at baseline than non-responders (0.99 (0.42–1.4) vs. 1.62 (0.96–2.41) pg/mL; p = 0.02). For the majority of patients, the IL-17A, IL-1β, and IFN-γ levels were below quantification limits. NLR and IL-6 may serve as predictive biomarkers of treatment response to TNF-α inhibitor therapy in patients with psoriasis.
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spelling pubmed-100944592023-04-13 Blood Cell Biomarkers of Inflammation and Cytokine Levels as Predictors of Response to Biologics in Patients with Psoriasis Andersen, Clara Sophie Bramsen Kvist-Hansen, Amanda Siewertsen, Mie Enevold, Christian Hansen, Peter Riis Kaur-Knudsen, Diljit Zachariae, Claus Nielsen, Claus Henrik Loft, Nikolai Skov, Lone Int J Mol Sci Article For people with psoriasis, biomarkers aiding in the personalization of treatment with biologics are needed. We examined the usefulness of several biomarkers of inflammation in this respect. The neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the systemic immune–inflammation index (SII) were measured in patients with psoriasis initiating TNF-α inhibitors (n = 131), IL-17/IL-17R inhibitors (n = 65), or IL-23/IL-12/23 inhibitors (n = 50). The blood levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, interferon (IFN)-γ, IL-17A, IL-6, soluble IL-6 receptor (sIL-6R), and soluble IL-6 signal transducer (sIL-6ST) were measured in patients initiating adalimumab (n = 62) or IL-17/IL-17R inhibitors (n = 24). Treatment response was defined by a psoriasis area and severity index (PASI) ≤ 2 three months after treatment initiation. Responders to TNF-α inhibitors had a lower NLR at baseline than non-responders (median and interquartile range (IQR) 2.15 (1.67–2.86) vs. 2.54 (1.88–3.55); p = 0.04). Responders to treatment with adalimumab had lower IL-6 levels at baseline than non-responders (0.99 (0.42–1.4) vs. 1.62 (0.96–2.41) pg/mL; p = 0.02). For the majority of patients, the IL-17A, IL-1β, and IFN-γ levels were below quantification limits. NLR and IL-6 may serve as predictive biomarkers of treatment response to TNF-α inhibitor therapy in patients with psoriasis. MDPI 2023-03-24 /pmc/articles/PMC10094459/ /pubmed/37047086 http://dx.doi.org/10.3390/ijms24076111 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Andersen, Clara Sophie Bramsen
Kvist-Hansen, Amanda
Siewertsen, Mie
Enevold, Christian
Hansen, Peter Riis
Kaur-Knudsen, Diljit
Zachariae, Claus
Nielsen, Claus Henrik
Loft, Nikolai
Skov, Lone
Blood Cell Biomarkers of Inflammation and Cytokine Levels as Predictors of Response to Biologics in Patients with Psoriasis
title Blood Cell Biomarkers of Inflammation and Cytokine Levels as Predictors of Response to Biologics in Patients with Psoriasis
title_full Blood Cell Biomarkers of Inflammation and Cytokine Levels as Predictors of Response to Biologics in Patients with Psoriasis
title_fullStr Blood Cell Biomarkers of Inflammation and Cytokine Levels as Predictors of Response to Biologics in Patients with Psoriasis
title_full_unstemmed Blood Cell Biomarkers of Inflammation and Cytokine Levels as Predictors of Response to Biologics in Patients with Psoriasis
title_short Blood Cell Biomarkers of Inflammation and Cytokine Levels as Predictors of Response to Biologics in Patients with Psoriasis
title_sort blood cell biomarkers of inflammation and cytokine levels as predictors of response to biologics in patients with psoriasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094459/
https://www.ncbi.nlm.nih.gov/pubmed/37047086
http://dx.doi.org/10.3390/ijms24076111
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