Mutation at the Site of Hydroxylation in the Ribosomal Protein uL15 (RPL27a) Causes Specific Changes in the Repertoire of mRNAs Translated in Mammalian Cells

Ribosomal protein uL15 (RPL27a) carries a specific modification, hydroxylation, at the His39 residue, which neighbors the CCA terminus of the E-site-bound tRNA at the mammalian ribosome. Under hypoxia, the level of hydroxylation of this protein decreases. We transiently transfected HEK293T cells wit...

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Detalles Bibliográficos
Autores principales: Zolotenkova, Elizaveta A., Gopanenko, Alexander V., Tupikin, Alexey E., Kabilov, Marsel R., Malygin, Alexey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094517/
https://www.ncbi.nlm.nih.gov/pubmed/37047141
http://dx.doi.org/10.3390/ijms24076173

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