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The Role of Gasotransmitter-Dependent Signaling Mechanisms in Apoptotic Cell Death in Cardiovascular, Rheumatic, Kidney, and Neurodegenerative Diseases and Mental Disorders
Cardiovascular, rheumatic, kidney, and neurodegenerative diseases and mental disorders are a common cause of deterioration in the quality of life up to severe disability and death worldwide. Many pathological conditions, including this group of diseases, are based on increased cell death through apo...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094524/ https://www.ncbi.nlm.nih.gov/pubmed/37046987 http://dx.doi.org/10.3390/ijms24076014 |
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author | Rodkin, Stanislav Nwosu, Chizaram Sannikov, Alexander Tyurin, Anton Chulkov, Vasilii Sergeevich Raevskaya, Margarita Ermakov, Alexey Kirichenko, Evgeniya Gasanov, Mitkhat |
author_facet | Rodkin, Stanislav Nwosu, Chizaram Sannikov, Alexander Tyurin, Anton Chulkov, Vasilii Sergeevich Raevskaya, Margarita Ermakov, Alexey Kirichenko, Evgeniya Gasanov, Mitkhat |
author_sort | Rodkin, Stanislav |
collection | PubMed |
description | Cardiovascular, rheumatic, kidney, and neurodegenerative diseases and mental disorders are a common cause of deterioration in the quality of life up to severe disability and death worldwide. Many pathological conditions, including this group of diseases, are based on increased cell death through apoptosis. It is known that this process is associated with signaling pathways controlled by a group of gaseous signaling molecules called gasotransmitters. They are unique messengers that can control the process of apoptosis at different stages of its implementation. However, their role in the regulation of apoptotic signaling in these pathological conditions is often controversial and not completely clear. This review analyzes the role of nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H(2)S), and sulfur dioxide (SO(2)) in apoptotic cell death in cardiovascular, rheumatic, kidney, and neurodegenerative diseases. The signaling processes involved in apoptosis in schizophrenia, bipolar, depressive, and anxiety disorders are also considered. The role of gasotransmitters in apoptosis in these diseases is largely determined by cell specificity and concentration. NO has the greatest dualism; scales are more prone to apoptosis. At the same time, CO, H(2)S, and SO(2) are more involved in cytoprotective processes. |
format | Online Article Text |
id | pubmed-10094524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100945242023-04-13 The Role of Gasotransmitter-Dependent Signaling Mechanisms in Apoptotic Cell Death in Cardiovascular, Rheumatic, Kidney, and Neurodegenerative Diseases and Mental Disorders Rodkin, Stanislav Nwosu, Chizaram Sannikov, Alexander Tyurin, Anton Chulkov, Vasilii Sergeevich Raevskaya, Margarita Ermakov, Alexey Kirichenko, Evgeniya Gasanov, Mitkhat Int J Mol Sci Review Cardiovascular, rheumatic, kidney, and neurodegenerative diseases and mental disorders are a common cause of deterioration in the quality of life up to severe disability and death worldwide. Many pathological conditions, including this group of diseases, are based on increased cell death through apoptosis. It is known that this process is associated with signaling pathways controlled by a group of gaseous signaling molecules called gasotransmitters. They are unique messengers that can control the process of apoptosis at different stages of its implementation. However, their role in the regulation of apoptotic signaling in these pathological conditions is often controversial and not completely clear. This review analyzes the role of nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H(2)S), and sulfur dioxide (SO(2)) in apoptotic cell death in cardiovascular, rheumatic, kidney, and neurodegenerative diseases. The signaling processes involved in apoptosis in schizophrenia, bipolar, depressive, and anxiety disorders are also considered. The role of gasotransmitters in apoptosis in these diseases is largely determined by cell specificity and concentration. NO has the greatest dualism; scales are more prone to apoptosis. At the same time, CO, H(2)S, and SO(2) are more involved in cytoprotective processes. MDPI 2023-03-23 /pmc/articles/PMC10094524/ /pubmed/37046987 http://dx.doi.org/10.3390/ijms24076014 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rodkin, Stanislav Nwosu, Chizaram Sannikov, Alexander Tyurin, Anton Chulkov, Vasilii Sergeevich Raevskaya, Margarita Ermakov, Alexey Kirichenko, Evgeniya Gasanov, Mitkhat The Role of Gasotransmitter-Dependent Signaling Mechanisms in Apoptotic Cell Death in Cardiovascular, Rheumatic, Kidney, and Neurodegenerative Diseases and Mental Disorders |
title | The Role of Gasotransmitter-Dependent Signaling Mechanisms in Apoptotic Cell Death in Cardiovascular, Rheumatic, Kidney, and Neurodegenerative Diseases and Mental Disorders |
title_full | The Role of Gasotransmitter-Dependent Signaling Mechanisms in Apoptotic Cell Death in Cardiovascular, Rheumatic, Kidney, and Neurodegenerative Diseases and Mental Disorders |
title_fullStr | The Role of Gasotransmitter-Dependent Signaling Mechanisms in Apoptotic Cell Death in Cardiovascular, Rheumatic, Kidney, and Neurodegenerative Diseases and Mental Disorders |
title_full_unstemmed | The Role of Gasotransmitter-Dependent Signaling Mechanisms in Apoptotic Cell Death in Cardiovascular, Rheumatic, Kidney, and Neurodegenerative Diseases and Mental Disorders |
title_short | The Role of Gasotransmitter-Dependent Signaling Mechanisms in Apoptotic Cell Death in Cardiovascular, Rheumatic, Kidney, and Neurodegenerative Diseases and Mental Disorders |
title_sort | role of gasotransmitter-dependent signaling mechanisms in apoptotic cell death in cardiovascular, rheumatic, kidney, and neurodegenerative diseases and mental disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094524/ https://www.ncbi.nlm.nih.gov/pubmed/37046987 http://dx.doi.org/10.3390/ijms24076014 |
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