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Influence of MMR, MGMT Promotor Methylation and Protein Expression on Overall and Progression-Free Survival in Primary Glioblastoma Patients Treated with Temozolomide

Glioblastoma is the most common malignant brain tumor in adults. Standard treatment includes tumor resection, radio-chemotherapy and adjuvant chemotherapy with temozolomide (TMZ). TMZ methylates DNA, whereas O6-methylguanine DNA methyltransferase (MGMT) counteracts TMZ effects by removing the intend...

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Detalles Bibliográficos
Autores principales:	Brawanski, Konstantin R., Sprung, Susanne, Freyschlag, Christian F., Hoeftberger, Romana, Ströbel, Thomas, Haybaeck, Johannes, Thomé, Claudius, Manzl, Claudia, Birkl-Toeglhofer, Anna M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094528/ https://www.ncbi.nlm.nih.gov/pubmed/37047153 http://dx.doi.org/10.3390/ijms24076184

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