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Fatty Acid Induced Hypermethylation in the Slc2a4 Gene in Visceral Adipose Tissue Is Associated to Insulin-Resistance and Obesity
De novo lipogenesis (DNL) in visceral adipose tissue (VAT) is associated with systemic insulin sensitivity. DNL in VAT is regulated through ChREBP activity and glucose uptake through Glut4 (encoded by Slc2a4). Slc2a4 expression, ChREBP activity, and DNL are decreased in obesity, the underlying cause...
Autores principales: | Britsemmer, Jan H., Krause, Christin, Taege, Natalie, Geißler, Cathleen, Lopez-Alcantara, Nuria, Schmidtke, Linda, Naujack, Alison-Michelle, Wagner, Jonas, Wolter, Stefan, Mann, Oliver, Kirchner, Henriette |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094548/ https://www.ncbi.nlm.nih.gov/pubmed/37047391 http://dx.doi.org/10.3390/ijms24076417 |
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