Proanthocyanidin Structure-Activity Relationship Analysis by Path Analysis Model

To fully explore the influence mechanism of interactions between different monomer units of proanthocyanidins (PAs) on biological activity, a path analysis model of the PA structure-activity relationship was proposed. This model subdivides the total correlation between each monomer unit and activity...

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Detalles Bibliográficos
Autores principales: Li, Zhaoxuan, Liu, Jingling, You, Jie, Li, Xin, Liang, Zongsuo, Du, Junli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094556/
https://www.ncbi.nlm.nih.gov/pubmed/37047349
http://dx.doi.org/10.3390/ijms24076379
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author Li, Zhaoxuan
Liu, Jingling
You, Jie
Li, Xin
Liang, Zongsuo
Du, Junli
author_facet Li, Zhaoxuan
Liu, Jingling
You, Jie
Li, Xin
Liang, Zongsuo
Du, Junli
author_sort Li, Zhaoxuan
collection PubMed
description To fully explore the influence mechanism of interactions between different monomer units of proanthocyanidins (PAs) on biological activity, a path analysis model of the PA structure-activity relationship was proposed. This model subdivides the total correlation between each monomer unit and activity into direct and indirect effects by taking into account not only each monomer unit but also the correlation with its related monomer units. In addition, this method can determine the action mode of each monomer unit affecting the activity by comparing the direct and total indirect effects. Finally, the advantage of this model is demonstrated through an influence mechanism analysis of Rhodiola crenulata PA monomer units on antioxidant and anti-diabetes activities.
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spelling pubmed-100945562023-04-13 Proanthocyanidin Structure-Activity Relationship Analysis by Path Analysis Model Li, Zhaoxuan Liu, Jingling You, Jie Li, Xin Liang, Zongsuo Du, Junli Int J Mol Sci Article To fully explore the influence mechanism of interactions between different monomer units of proanthocyanidins (PAs) on biological activity, a path analysis model of the PA structure-activity relationship was proposed. This model subdivides the total correlation between each monomer unit and activity into direct and indirect effects by taking into account not only each monomer unit but also the correlation with its related monomer units. In addition, this method can determine the action mode of each monomer unit affecting the activity by comparing the direct and total indirect effects. Finally, the advantage of this model is demonstrated through an influence mechanism analysis of Rhodiola crenulata PA monomer units on antioxidant and anti-diabetes activities. MDPI 2023-03-28 /pmc/articles/PMC10094556/ /pubmed/37047349 http://dx.doi.org/10.3390/ijms24076379 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Zhaoxuan
Liu, Jingling
You, Jie
Li, Xin
Liang, Zongsuo
Du, Junli
Proanthocyanidin Structure-Activity Relationship Analysis by Path Analysis Model
title Proanthocyanidin Structure-Activity Relationship Analysis by Path Analysis Model
title_full Proanthocyanidin Structure-Activity Relationship Analysis by Path Analysis Model
title_fullStr Proanthocyanidin Structure-Activity Relationship Analysis by Path Analysis Model
title_full_unstemmed Proanthocyanidin Structure-Activity Relationship Analysis by Path Analysis Model
title_short Proanthocyanidin Structure-Activity Relationship Analysis by Path Analysis Model
title_sort proanthocyanidin structure-activity relationship analysis by path analysis model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094556/
https://www.ncbi.nlm.nih.gov/pubmed/37047349
http://dx.doi.org/10.3390/ijms24076379
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AT lixin proanthocyanidinstructureactivityrelationshipanalysisbypathanalysismodel
AT liangzongsuo proanthocyanidinstructureactivityrelationshipanalysisbypathanalysismodel
AT dujunli proanthocyanidinstructureactivityrelationshipanalysisbypathanalysismodel

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