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Autophagy: A Potential Therapeutic Target to Tackle Drug Resistance in Multiple Myeloma
Multiple myeloma (MM) is the second most prevalent hematologic malignancy. In the past few years, the survival of MM patients has increased due to the emergence of novel drugs and combination therapies. Nevertheless, one of the significant obstacles in treating most MM patients is drug resistance, e...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094562/ https://www.ncbi.nlm.nih.gov/pubmed/37046991 http://dx.doi.org/10.3390/ijms24076019 |
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author | Bashiri, Hamed Tabatabaeian, Hossein |
author_facet | Bashiri, Hamed Tabatabaeian, Hossein |
author_sort | Bashiri, Hamed |
collection | PubMed |
description | Multiple myeloma (MM) is the second most prevalent hematologic malignancy. In the past few years, the survival of MM patients has increased due to the emergence of novel drugs and combination therapies. Nevertheless, one of the significant obstacles in treating most MM patients is drug resistance, especially for individuals who have experienced relapses or developed resistance to such cutting-edge treatments. One of the critical processes in developing drug resistance in MM is autophagic activity, an intracellular self-digestive process. Several possible strategies of autophagy involvement in the induction of MM-drug resistance have been demonstrated thus far. In multiple myeloma, it has been shown that High mobility group box protein 1 (HMGB1)-dependent autophagy can contribute to drug resistance. Moreover, activation of autophagy via proteasome suppression induces drug resistance. Additionally, the effectiveness of clarithromycin as a supplemental drug in treating MM has been reported recently, in which autophagy blockage is proposed as one of the potential action mechanisms of CAM. Thus, a promising therapeutic approach that targets autophagy to trigger the death of MM cells and improve drug susceptibility could be considered. In this review, autophagy has been addressed as a survival strategy crucial for drug resistance in MM. |
format | Online Article Text |
id | pubmed-10094562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100945622023-04-13 Autophagy: A Potential Therapeutic Target to Tackle Drug Resistance in Multiple Myeloma Bashiri, Hamed Tabatabaeian, Hossein Int J Mol Sci Review Multiple myeloma (MM) is the second most prevalent hematologic malignancy. In the past few years, the survival of MM patients has increased due to the emergence of novel drugs and combination therapies. Nevertheless, one of the significant obstacles in treating most MM patients is drug resistance, especially for individuals who have experienced relapses or developed resistance to such cutting-edge treatments. One of the critical processes in developing drug resistance in MM is autophagic activity, an intracellular self-digestive process. Several possible strategies of autophagy involvement in the induction of MM-drug resistance have been demonstrated thus far. In multiple myeloma, it has been shown that High mobility group box protein 1 (HMGB1)-dependent autophagy can contribute to drug resistance. Moreover, activation of autophagy via proteasome suppression induces drug resistance. Additionally, the effectiveness of clarithromycin as a supplemental drug in treating MM has been reported recently, in which autophagy blockage is proposed as one of the potential action mechanisms of CAM. Thus, a promising therapeutic approach that targets autophagy to trigger the death of MM cells and improve drug susceptibility could be considered. In this review, autophagy has been addressed as a survival strategy crucial for drug resistance in MM. MDPI 2023-03-23 /pmc/articles/PMC10094562/ /pubmed/37046991 http://dx.doi.org/10.3390/ijms24076019 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bashiri, Hamed Tabatabaeian, Hossein Autophagy: A Potential Therapeutic Target to Tackle Drug Resistance in Multiple Myeloma |
title | Autophagy: A Potential Therapeutic Target to Tackle Drug Resistance in Multiple Myeloma |
title_full | Autophagy: A Potential Therapeutic Target to Tackle Drug Resistance in Multiple Myeloma |
title_fullStr | Autophagy: A Potential Therapeutic Target to Tackle Drug Resistance in Multiple Myeloma |
title_full_unstemmed | Autophagy: A Potential Therapeutic Target to Tackle Drug Resistance in Multiple Myeloma |
title_short | Autophagy: A Potential Therapeutic Target to Tackle Drug Resistance in Multiple Myeloma |
title_sort | autophagy: a potential therapeutic target to tackle drug resistance in multiple myeloma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094562/ https://www.ncbi.nlm.nih.gov/pubmed/37046991 http://dx.doi.org/10.3390/ijms24076019 |
work_keys_str_mv | AT bashirihamed autophagyapotentialtherapeutictargettotackledrugresistanceinmultiplemyeloma AT tabatabaeianhossein autophagyapotentialtherapeutictargettotackledrugresistanceinmultiplemyeloma |