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The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic Diseases

Cardiometabolic diseases (CMDs), including cardiovascular disease (CVD), metabolic syndrome (MetS), and type 2 diabetes (T2D), are associated with increased morbidity and mortality. The growing prevalence of CVD is mostly attributed to the aging population and common occurrence of risk factors, such...

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Autores principales: Świątkiewicz, Iwona, Wróblewski, Marcin, Nuszkiewicz, Jarosław, Sutkowy, Paweł, Wróblewska, Joanna, Woźniak, Alina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094567/
https://www.ncbi.nlm.nih.gov/pubmed/37047352
http://dx.doi.org/10.3390/ijms24076382
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author Świątkiewicz, Iwona
Wróblewski, Marcin
Nuszkiewicz, Jarosław
Sutkowy, Paweł
Wróblewska, Joanna
Woźniak, Alina
author_facet Świątkiewicz, Iwona
Wróblewski, Marcin
Nuszkiewicz, Jarosław
Sutkowy, Paweł
Wróblewska, Joanna
Woźniak, Alina
author_sort Świątkiewicz, Iwona
collection PubMed
description Cardiometabolic diseases (CMDs), including cardiovascular disease (CVD), metabolic syndrome (MetS), and type 2 diabetes (T2D), are associated with increased morbidity and mortality. The growing prevalence of CVD is mostly attributed to the aging population and common occurrence of risk factors, such as high systolic blood pressure, elevated plasma glucose, and increased body mass index, which led to a global epidemic of obesity, MetS, and T2D. Oxidant–antioxidant balance disorders largely contribute to the pathogenesis and outcomes of CMDs, such as systemic essential hypertension, coronary artery disease, stroke, and MetS. Enhanced and disturbed generation of reactive oxygen species in excess adipose tissue during obesity may lead to increased oxidative stress. Understanding the interplay between adiposity, oxidative stress, and cardiometabolic risks can have translational impacts, leading to the identification of novel effective strategies for reducing the CMDs burden. The present review article is based on extant results from basic and clinical studies and specifically addresses the various aspects associated with oxidant–antioxidant balance disorders in the course of CMDs in subjects with excess adipose tissue accumulation. We aim at giving a comprehensive overview of existing knowledge, knowledge gaps, and future perspectives for further basic and clinical research. We provide insights into both the mechanisms and clinical implications of effects related to the interplay between adiposity and oxidative stress for treating and preventing CMDs. Future basic research and clinical trials are needed to further examine the mechanisms of adiposity-enhanced oxidative stress in CMDs and the efficacy of antioxidant therapies for reducing risk and improving outcome of patients with CMDs.
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spelling pubmed-100945672023-04-13 The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic Diseases Świątkiewicz, Iwona Wróblewski, Marcin Nuszkiewicz, Jarosław Sutkowy, Paweł Wróblewska, Joanna Woźniak, Alina Int J Mol Sci Review Cardiometabolic diseases (CMDs), including cardiovascular disease (CVD), metabolic syndrome (MetS), and type 2 diabetes (T2D), are associated with increased morbidity and mortality. The growing prevalence of CVD is mostly attributed to the aging population and common occurrence of risk factors, such as high systolic blood pressure, elevated plasma glucose, and increased body mass index, which led to a global epidemic of obesity, MetS, and T2D. Oxidant–antioxidant balance disorders largely contribute to the pathogenesis and outcomes of CMDs, such as systemic essential hypertension, coronary artery disease, stroke, and MetS. Enhanced and disturbed generation of reactive oxygen species in excess adipose tissue during obesity may lead to increased oxidative stress. Understanding the interplay between adiposity, oxidative stress, and cardiometabolic risks can have translational impacts, leading to the identification of novel effective strategies for reducing the CMDs burden. The present review article is based on extant results from basic and clinical studies and specifically addresses the various aspects associated with oxidant–antioxidant balance disorders in the course of CMDs in subjects with excess adipose tissue accumulation. We aim at giving a comprehensive overview of existing knowledge, knowledge gaps, and future perspectives for further basic and clinical research. We provide insights into both the mechanisms and clinical implications of effects related to the interplay between adiposity and oxidative stress for treating and preventing CMDs. Future basic research and clinical trials are needed to further examine the mechanisms of adiposity-enhanced oxidative stress in CMDs and the efficacy of antioxidant therapies for reducing risk and improving outcome of patients with CMDs. MDPI 2023-03-28 /pmc/articles/PMC10094567/ /pubmed/37047352 http://dx.doi.org/10.3390/ijms24076382 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Świątkiewicz, Iwona
Wróblewski, Marcin
Nuszkiewicz, Jarosław
Sutkowy, Paweł
Wróblewska, Joanna
Woźniak, Alina
The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic Diseases
title The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic Diseases
title_full The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic Diseases
title_fullStr The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic Diseases
title_full_unstemmed The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic Diseases
title_short The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic Diseases
title_sort role of oxidative stress enhanced by adiposity in cardiometabolic diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094567/
https://www.ncbi.nlm.nih.gov/pubmed/37047352
http://dx.doi.org/10.3390/ijms24076382
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