HED, a Human-Engineered Domain, Confers a Unique Fc-Binding Activity to Produce a New Class of Humanized Antibody-like Molecules

Our laboratory has identified and developed a unique human-engineered domain (HED) structure that was obtained from the human Alpha-2-macroglobulin receptor-associated protein based on the three-dimensional structure of the Z-domain derived from Staphylococcal protein A. This HED retains µM binding...

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Detalles Bibliográficos
Autores principales: Zhu, Zhiqiang, Goel, Peeyush N., Zheng, Cai, Nagai, Yasuhiro, Lam, Lian, Samanta, Arabinda, Ji, Meiqing, Zhang, Hongtao, Greene, Mark I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094569/
https://www.ncbi.nlm.nih.gov/pubmed/37047449
http://dx.doi.org/10.3390/ijms24076477

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