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Contribution of the L-Type Amino Acid Transporter Family in the Diagnosis and Treatment of Prostate Cancer

The L-type amino acid transporter (LAT) family contains four members, LAT1~4, which are important amino acid transporters. They mainly transport specific amino acids through cell membranes, provide nutrients to cells, and are involved in a variety of metabolic pathways. They regulate the mTOR signal...

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Autores principales: Zhao, Xue, Sakamoto, Shinichi, Wei, Jiaxing, Pae, Sangjon, Saito, Shinpei, Sazuka, Tomokazu, Imamura, Yusuke, Anzai, Naohiko, Ichikawa, Tomohiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094571/
https://www.ncbi.nlm.nih.gov/pubmed/37047148
http://dx.doi.org/10.3390/ijms24076178
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author Zhao, Xue
Sakamoto, Shinichi
Wei, Jiaxing
Pae, Sangjon
Saito, Shinpei
Sazuka, Tomokazu
Imamura, Yusuke
Anzai, Naohiko
Ichikawa, Tomohiko
author_facet Zhao, Xue
Sakamoto, Shinichi
Wei, Jiaxing
Pae, Sangjon
Saito, Shinpei
Sazuka, Tomokazu
Imamura, Yusuke
Anzai, Naohiko
Ichikawa, Tomohiko
author_sort Zhao, Xue
collection PubMed
description The L-type amino acid transporter (LAT) family contains four members, LAT1~4, which are important amino acid transporters. They mainly transport specific amino acids through cell membranes, provide nutrients to cells, and are involved in a variety of metabolic pathways. They regulate the mTOR signaling pathway which has been found to be strongly linked to cancer in recent years. However, in the field of prostate cancer (PCa), the LAT family is still in the nascent stage of research, and the importance of LATs in the diagnosis and treatment of prostate cancer is still unknown. Therefore, this article aims to report the role of LATs in prostate cancer and their clinical significance and application. LATs promote the progression of prostate cancer by increasing amino acid uptake, activating the mammalian target of rapamycin (mTOR) pathway and downstream signals, mediating castration-resistance, promoting tumor angiogenesis, and enhancing chemotherapy resistance. The importance of LATs as diagnostic and therapeutic targets for prostate cancer was emphasized and the latest research results were introduced. In addition, we introduced selective LAT1 inhibitors, including JPH203 and OKY034, which showed excellent inhibitory effects on the proliferation of various tumor cells. This is the future direction of amino acid transporter targeting therapy drugs.
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spelling pubmed-100945712023-04-13 Contribution of the L-Type Amino Acid Transporter Family in the Diagnosis and Treatment of Prostate Cancer Zhao, Xue Sakamoto, Shinichi Wei, Jiaxing Pae, Sangjon Saito, Shinpei Sazuka, Tomokazu Imamura, Yusuke Anzai, Naohiko Ichikawa, Tomohiko Int J Mol Sci Review The L-type amino acid transporter (LAT) family contains four members, LAT1~4, which are important amino acid transporters. They mainly transport specific amino acids through cell membranes, provide nutrients to cells, and are involved in a variety of metabolic pathways. They regulate the mTOR signaling pathway which has been found to be strongly linked to cancer in recent years. However, in the field of prostate cancer (PCa), the LAT family is still in the nascent stage of research, and the importance of LATs in the diagnosis and treatment of prostate cancer is still unknown. Therefore, this article aims to report the role of LATs in prostate cancer and their clinical significance and application. LATs promote the progression of prostate cancer by increasing amino acid uptake, activating the mammalian target of rapamycin (mTOR) pathway and downstream signals, mediating castration-resistance, promoting tumor angiogenesis, and enhancing chemotherapy resistance. The importance of LATs as diagnostic and therapeutic targets for prostate cancer was emphasized and the latest research results were introduced. In addition, we introduced selective LAT1 inhibitors, including JPH203 and OKY034, which showed excellent inhibitory effects on the proliferation of various tumor cells. This is the future direction of amino acid transporter targeting therapy drugs. MDPI 2023-03-24 /pmc/articles/PMC10094571/ /pubmed/37047148 http://dx.doi.org/10.3390/ijms24076178 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhao, Xue
Sakamoto, Shinichi
Wei, Jiaxing
Pae, Sangjon
Saito, Shinpei
Sazuka, Tomokazu
Imamura, Yusuke
Anzai, Naohiko
Ichikawa, Tomohiko
Contribution of the L-Type Amino Acid Transporter Family in the Diagnosis and Treatment of Prostate Cancer
title Contribution of the L-Type Amino Acid Transporter Family in the Diagnosis and Treatment of Prostate Cancer
title_full Contribution of the L-Type Amino Acid Transporter Family in the Diagnosis and Treatment of Prostate Cancer
title_fullStr Contribution of the L-Type Amino Acid Transporter Family in the Diagnosis and Treatment of Prostate Cancer
title_full_unstemmed Contribution of the L-Type Amino Acid Transporter Family in the Diagnosis and Treatment of Prostate Cancer
title_short Contribution of the L-Type Amino Acid Transporter Family in the Diagnosis and Treatment of Prostate Cancer
title_sort contribution of the l-type amino acid transporter family in the diagnosis and treatment of prostate cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094571/
https://www.ncbi.nlm.nih.gov/pubmed/37047148
http://dx.doi.org/10.3390/ijms24076178
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