Chemical Space Virtual Screening against Hard-to-Drug RNA Methyltransferases DNMT2 and NSUN6

Targeting RNA methyltransferases with small molecules as inhibitors or tool compounds is an emerging field of interest in epitranscriptomics and medicinal chemistry. For two challenging RNA methyltransferases that introduce the 5-methylcytosine (m(5)C) modification in different tRNAs, namely DNMT2 a...

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Detalles Bibliográficos
Autores principales: Zimmermann, Robert A., Fischer, Tim R., Schwickert, Marvin, Nidoieva, Zarina, Schirmeister, Tanja, Kersten, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094593/
https://www.ncbi.nlm.nih.gov/pubmed/37047081
http://dx.doi.org/10.3390/ijms24076109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094593/
https://www.ncbi.nlm.nih.gov/pubmed/37047081
http://dx.doi.org/10.3390/ijms24076109

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