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Enzymatic Synthesis of 2-Chloropurine Arabinonucleosides with Chiral Amino Acid Amides at the C6 Position and an Evaluation of Antiproliferative Activity In Vitro

A number of purine arabinosides containing chiral amino acid amides at the C6 position of the purine were synthesized using a transglycosylation reaction with recombinant E. coli nucleoside phosphorylases. Arsenolysis of 2-chloropurine ribosides with chiral amino acid amides at C6 was used for the e...

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Detalles Bibliográficos
Autores principales:	Eletskaya, Barbara Z., Berzina, Maria Ya., Fateev, Ilya V., Kayushin, Alexei L., Dorofeeva, Elena V., Lutonina, Olga I., Zorina, Ekaterina A., Antonov, Konstantin V., Paramonov, Alexander S., Muzyka, Inessa S., Zhukova, Olga S., Kiselevskiy, Mikhail V., Miroshnikov, Anatoly I., Esipov, Roman S., Konstantinova, Irina D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094600/ https://www.ncbi.nlm.nih.gov/pubmed/37047197 http://dx.doi.org/10.3390/ijms24076223

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