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Mitigation of Cardiovascular Disease and Toxicity through NRF2 Signalling

Cardiovascular toxicity and diseases are phenomena that have a vastly detrimental impact on morbidity and mortality. The pathophysiology driving the development of these conditions is multifactorial but commonly includes the perturbance of reactive oxygen species (ROS) signalling, iron homeostasis a...

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Autores principales: Roberts, James A., Rainbow, Richard D., Sharma, Parveen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094784/
https://www.ncbi.nlm.nih.gov/pubmed/37047696
http://dx.doi.org/10.3390/ijms24076723
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author Roberts, James A.
Rainbow, Richard D.
Sharma, Parveen
author_facet Roberts, James A.
Rainbow, Richard D.
Sharma, Parveen
author_sort Roberts, James A.
collection PubMed
description Cardiovascular toxicity and diseases are phenomena that have a vastly detrimental impact on morbidity and mortality. The pathophysiology driving the development of these conditions is multifactorial but commonly includes the perturbance of reactive oxygen species (ROS) signalling, iron homeostasis and mitochondrial bioenergetics. The transcription factor nuclear factor erythroid 2 (NFE2)-related factor 2 (NRF2), a master regulator of cytoprotective responses, drives the expression of genes that provide resistance to oxidative, electrophilic and xenobiotic stresses. Recent research has suggested that stimulation of the NRF2 signalling pathway can alleviate cardiotoxicity and hallmarks of cardiovascular disease progression. However, dysregulation of NRF2 dynamic responses can be severely impacted by ageing processes and off-target toxicity from clinical medicines including anthracycline chemotherapeutics, rendering cells of the cardiovascular system susceptible to toxicity and subsequent tissue dysfunction. This review addresses the current understanding of NRF2 mechanisms under homeostatic and cardiovascular pathophysiological conditions within the context of wider implications for this diverse transcription factor.
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spelling pubmed-100947842023-04-13 Mitigation of Cardiovascular Disease and Toxicity through NRF2 Signalling Roberts, James A. Rainbow, Richard D. Sharma, Parveen Int J Mol Sci Review Cardiovascular toxicity and diseases are phenomena that have a vastly detrimental impact on morbidity and mortality. The pathophysiology driving the development of these conditions is multifactorial but commonly includes the perturbance of reactive oxygen species (ROS) signalling, iron homeostasis and mitochondrial bioenergetics. The transcription factor nuclear factor erythroid 2 (NFE2)-related factor 2 (NRF2), a master regulator of cytoprotective responses, drives the expression of genes that provide resistance to oxidative, electrophilic and xenobiotic stresses. Recent research has suggested that stimulation of the NRF2 signalling pathway can alleviate cardiotoxicity and hallmarks of cardiovascular disease progression. However, dysregulation of NRF2 dynamic responses can be severely impacted by ageing processes and off-target toxicity from clinical medicines including anthracycline chemotherapeutics, rendering cells of the cardiovascular system susceptible to toxicity and subsequent tissue dysfunction. This review addresses the current understanding of NRF2 mechanisms under homeostatic and cardiovascular pathophysiological conditions within the context of wider implications for this diverse transcription factor. MDPI 2023-04-04 /pmc/articles/PMC10094784/ /pubmed/37047696 http://dx.doi.org/10.3390/ijms24076723 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Roberts, James A.
Rainbow, Richard D.
Sharma, Parveen
Mitigation of Cardiovascular Disease and Toxicity through NRF2 Signalling
title Mitigation of Cardiovascular Disease and Toxicity through NRF2 Signalling
title_full Mitigation of Cardiovascular Disease and Toxicity through NRF2 Signalling
title_fullStr Mitigation of Cardiovascular Disease and Toxicity through NRF2 Signalling
title_full_unstemmed Mitigation of Cardiovascular Disease and Toxicity through NRF2 Signalling
title_short Mitigation of Cardiovascular Disease and Toxicity through NRF2 Signalling
title_sort mitigation of cardiovascular disease and toxicity through nrf2 signalling
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094784/
https://www.ncbi.nlm.nih.gov/pubmed/37047696
http://dx.doi.org/10.3390/ijms24076723
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