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Microwave Ablation of Recurrent Hepatocellular Carcinoma after Curative Surgical Resection

Purpose: To evaluate the efficacy and safety of microwave ablation (MWA) as a treatment for recurrent hepatocellular carcinoma (HCC) after initial successful surgical resection. Methods: This retrospective study included 40 patients (11 women and 29 men; mean age: 62.3 ± 11.7 years) with 48 recurren...

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Autores principales: Adwan, Hamzah, Hammann, Lars, Vogl, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094797/
https://www.ncbi.nlm.nih.gov/pubmed/37048644
http://dx.doi.org/10.3390/jcm12072560
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author Adwan, Hamzah
Hammann, Lars
Vogl, Thomas J.
author_facet Adwan, Hamzah
Hammann, Lars
Vogl, Thomas J.
author_sort Adwan, Hamzah
collection PubMed
description Purpose: To evaluate the efficacy and safety of microwave ablation (MWA) as a treatment for recurrent hepatocellular carcinoma (HCC) after initial successful surgical resection. Methods: This retrospective study included 40 patients (11 women and 29 men; mean age: 62.3 ± 11.7 years) with 48 recurrent lesions of HCC after initial surgical resection that were treated by percutaneous MWA. Several parameters including complications, technical success, local tumor progression (LTP), intrahepatic distant recurrence (IDR), overall survival (OS), and progression-free survival (PFS) were evaluated in order to investigate the safety and efficacy of MWA for these recurrent HCC lesions after surgical treatment. Results: All MWA treatments were performed without complications or procedure-related deaths. Technical success was achieved in all cases. Two cases developed LTP at a rate of 5%, and IDR occurred in 23 cases at a rate of 57.5% (23/40). The 1-, 2-, 3-, 4-, and 6-year OS rates were 97%, 89.2%, 80.3%, 70.2%, and 60.2%, respectively. The 1- and 3-year PFS rates were 50.2% and 34.6%, respectively. Conclusion: MWA is effective and safe as a local treatment for recurrent HCC after initial surgical resection.
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spelling pubmed-100947972023-04-13 Microwave Ablation of Recurrent Hepatocellular Carcinoma after Curative Surgical Resection Adwan, Hamzah Hammann, Lars Vogl, Thomas J. J Clin Med Article Purpose: To evaluate the efficacy and safety of microwave ablation (MWA) as a treatment for recurrent hepatocellular carcinoma (HCC) after initial successful surgical resection. Methods: This retrospective study included 40 patients (11 women and 29 men; mean age: 62.3 ± 11.7 years) with 48 recurrent lesions of HCC after initial surgical resection that were treated by percutaneous MWA. Several parameters including complications, technical success, local tumor progression (LTP), intrahepatic distant recurrence (IDR), overall survival (OS), and progression-free survival (PFS) were evaluated in order to investigate the safety and efficacy of MWA for these recurrent HCC lesions after surgical treatment. Results: All MWA treatments were performed without complications or procedure-related deaths. Technical success was achieved in all cases. Two cases developed LTP at a rate of 5%, and IDR occurred in 23 cases at a rate of 57.5% (23/40). The 1-, 2-, 3-, 4-, and 6-year OS rates were 97%, 89.2%, 80.3%, 70.2%, and 60.2%, respectively. The 1- and 3-year PFS rates were 50.2% and 34.6%, respectively. Conclusion: MWA is effective and safe as a local treatment for recurrent HCC after initial surgical resection. MDPI 2023-03-29 /pmc/articles/PMC10094797/ /pubmed/37048644 http://dx.doi.org/10.3390/jcm12072560 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Adwan, Hamzah
Hammann, Lars
Vogl, Thomas J.
Microwave Ablation of Recurrent Hepatocellular Carcinoma after Curative Surgical Resection
title Microwave Ablation of Recurrent Hepatocellular Carcinoma after Curative Surgical Resection
title_full Microwave Ablation of Recurrent Hepatocellular Carcinoma after Curative Surgical Resection
title_fullStr Microwave Ablation of Recurrent Hepatocellular Carcinoma after Curative Surgical Resection
title_full_unstemmed Microwave Ablation of Recurrent Hepatocellular Carcinoma after Curative Surgical Resection
title_short Microwave Ablation of Recurrent Hepatocellular Carcinoma after Curative Surgical Resection
title_sort microwave ablation of recurrent hepatocellular carcinoma after curative surgical resection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094797/
https://www.ncbi.nlm.nih.gov/pubmed/37048644
http://dx.doi.org/10.3390/jcm12072560
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