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Characteristics and Predictors of Alzheimer’s Disease Resilience Phenotype

Alzheimer’s disease (AD) is characterized by cognitive impairment in the presence of cerebral amyloid plaques and neurofibrillary tangles. Less is known about the characteristics and predictors of resilience to cognitive impairment in the presence of neuropathological evidence of AD, the focus of th...

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Autores principales: Sin, Mo-Kyung, Cheng, Yan, Roseman, Jeffrey M., Latimer, Caitlin, Ahmed, Ali, Zamrini, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094896/
https://www.ncbi.nlm.nih.gov/pubmed/37048547
http://dx.doi.org/10.3390/jcm12072463
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author Sin, Mo-Kyung
Cheng, Yan
Roseman, Jeffrey M.
Latimer, Caitlin
Ahmed, Ali
Zamrini, Edward
author_facet Sin, Mo-Kyung
Cheng, Yan
Roseman, Jeffrey M.
Latimer, Caitlin
Ahmed, Ali
Zamrini, Edward
author_sort Sin, Mo-Kyung
collection PubMed
description Alzheimer’s disease (AD) is characterized by cognitive impairment in the presence of cerebral amyloid plaques and neurofibrillary tangles. Less is known about the characteristics and predictors of resilience to cognitive impairment in the presence of neuropathological evidence of AD, the focus of this study. Of 3170 adults age ≥65 years in the National Alzheimer’s Coordinating Center (NACC) brain autopsy cohort, 1373 had evidence of CERAD level moderate to frequent neuritic plaque density and Braak stage V–VI neurofibrillary tangles. Resilience was defined by CDR-SOB and CDR-Global scores of 0–2.5 and 0–0.5, respectively, and non-resilience, CDR-SOB and CDR-Global scores >2.5 and >0.5, respectively. Multivariable logistic regression models were used to examine the independent associations of patient characteristics with resilience. There were 62 participants (4.8%) with resilience. Those with resilience were older (mean age, 88.3 vs. 82.4 years), more likely to be women (61.3% vs. 47.3%) and had a lower prevalence of the APOE-e4 carrier (41.9% vs. 56.2%). They also had a higher prevalence of hypertension, heart failure, atrial fibrillation, diuretic use, beta-blocker use, and APOE-e2 carrier status. Greater age at death, diuretic use, and APOE-e2 were the only characteristics independently associated with higher odds of the AD resilience phenotype (adjusted OR, 1.09; 95% CI, 1.05–1.13; p < 0.01; 2.00 (1.04–3.87), p = 0.04, 2.71 (1.31–5.64), p < 0.01, respectively). The phenotype of resilience to cognitive impairment is uncommon in older adults who have neuropathological evidence of AD.
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spelling pubmed-100948962023-04-13 Characteristics and Predictors of Alzheimer’s Disease Resilience Phenotype Sin, Mo-Kyung Cheng, Yan Roseman, Jeffrey M. Latimer, Caitlin Ahmed, Ali Zamrini, Edward J Clin Med Article Alzheimer’s disease (AD) is characterized by cognitive impairment in the presence of cerebral amyloid plaques and neurofibrillary tangles. Less is known about the characteristics and predictors of resilience to cognitive impairment in the presence of neuropathological evidence of AD, the focus of this study. Of 3170 adults age ≥65 years in the National Alzheimer’s Coordinating Center (NACC) brain autopsy cohort, 1373 had evidence of CERAD level moderate to frequent neuritic plaque density and Braak stage V–VI neurofibrillary tangles. Resilience was defined by CDR-SOB and CDR-Global scores of 0–2.5 and 0–0.5, respectively, and non-resilience, CDR-SOB and CDR-Global scores >2.5 and >0.5, respectively. Multivariable logistic regression models were used to examine the independent associations of patient characteristics with resilience. There were 62 participants (4.8%) with resilience. Those with resilience were older (mean age, 88.3 vs. 82.4 years), more likely to be women (61.3% vs. 47.3%) and had a lower prevalence of the APOE-e4 carrier (41.9% vs. 56.2%). They also had a higher prevalence of hypertension, heart failure, atrial fibrillation, diuretic use, beta-blocker use, and APOE-e2 carrier status. Greater age at death, diuretic use, and APOE-e2 were the only characteristics independently associated with higher odds of the AD resilience phenotype (adjusted OR, 1.09; 95% CI, 1.05–1.13; p < 0.01; 2.00 (1.04–3.87), p = 0.04, 2.71 (1.31–5.64), p < 0.01, respectively). The phenotype of resilience to cognitive impairment is uncommon in older adults who have neuropathological evidence of AD. MDPI 2023-03-23 /pmc/articles/PMC10094896/ /pubmed/37048547 http://dx.doi.org/10.3390/jcm12072463 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sin, Mo-Kyung
Cheng, Yan
Roseman, Jeffrey M.
Latimer, Caitlin
Ahmed, Ali
Zamrini, Edward
Characteristics and Predictors of Alzheimer’s Disease Resilience Phenotype
title Characteristics and Predictors of Alzheimer’s Disease Resilience Phenotype
title_full Characteristics and Predictors of Alzheimer’s Disease Resilience Phenotype
title_fullStr Characteristics and Predictors of Alzheimer’s Disease Resilience Phenotype
title_full_unstemmed Characteristics and Predictors of Alzheimer’s Disease Resilience Phenotype
title_short Characteristics and Predictors of Alzheimer’s Disease Resilience Phenotype
title_sort characteristics and predictors of alzheimer’s disease resilience phenotype
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094896/
https://www.ncbi.nlm.nih.gov/pubmed/37048547
http://dx.doi.org/10.3390/jcm12072463
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