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Extracellular Vesicles as Potential Bladder Cancer Biomarkers: Take It or Leave It?

Bladder cancer (BC) is the 10th most frequently diagnosed cancer worldwide. Although urine cytology and cystoscopy are current standards for BC diagnosis, both have limited sensitivity to detect low-grade and small tumors. Moreover, effective prognostic biomarkers are lacking. Extracellular vesicles...

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Autores principales: Teixeira-Marques, Ana, Lourenço, Catarina, Oliveira, Miguel Carlos, Henrique, Rui, Jerónimo, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094914/
https://www.ncbi.nlm.nih.gov/pubmed/37047731
http://dx.doi.org/10.3390/ijms24076757
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author Teixeira-Marques, Ana
Lourenço, Catarina
Oliveira, Miguel Carlos
Henrique, Rui
Jerónimo, Carmen
author_facet Teixeira-Marques, Ana
Lourenço, Catarina
Oliveira, Miguel Carlos
Henrique, Rui
Jerónimo, Carmen
author_sort Teixeira-Marques, Ana
collection PubMed
description Bladder cancer (BC) is the 10th most frequently diagnosed cancer worldwide. Although urine cytology and cystoscopy are current standards for BC diagnosis, both have limited sensitivity to detect low-grade and small tumors. Moreover, effective prognostic biomarkers are lacking. Extracellular vesicles (EVs) are lipidic particles that contain nucleic acids, proteins, and metabolites, which are released by cells into the extracellular space, being crucial effectors in intercellular communication. These particles have emerged as potential tools carrying biomarkers for either diagnosis or prognosis in liquid biopsies namely urine, plasma, and serum. Herein, we review the potential of liquid biopsies EVs’ cargo as BC diagnosis and prognosis biomarkers. Additionally, we address the emerging advantages and downsides of using EVs within this framework.
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spelling pubmed-100949142023-04-13 Extracellular Vesicles as Potential Bladder Cancer Biomarkers: Take It or Leave It? Teixeira-Marques, Ana Lourenço, Catarina Oliveira, Miguel Carlos Henrique, Rui Jerónimo, Carmen Int J Mol Sci Review Bladder cancer (BC) is the 10th most frequently diagnosed cancer worldwide. Although urine cytology and cystoscopy are current standards for BC diagnosis, both have limited sensitivity to detect low-grade and small tumors. Moreover, effective prognostic biomarkers are lacking. Extracellular vesicles (EVs) are lipidic particles that contain nucleic acids, proteins, and metabolites, which are released by cells into the extracellular space, being crucial effectors in intercellular communication. These particles have emerged as potential tools carrying biomarkers for either diagnosis or prognosis in liquid biopsies namely urine, plasma, and serum. Herein, we review the potential of liquid biopsies EVs’ cargo as BC diagnosis and prognosis biomarkers. Additionally, we address the emerging advantages and downsides of using EVs within this framework. MDPI 2023-04-04 /pmc/articles/PMC10094914/ /pubmed/37047731 http://dx.doi.org/10.3390/ijms24076757 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Teixeira-Marques, Ana
Lourenço, Catarina
Oliveira, Miguel Carlos
Henrique, Rui
Jerónimo, Carmen
Extracellular Vesicles as Potential Bladder Cancer Biomarkers: Take It or Leave It?
title Extracellular Vesicles as Potential Bladder Cancer Biomarkers: Take It or Leave It?
title_full Extracellular Vesicles as Potential Bladder Cancer Biomarkers: Take It or Leave It?
title_fullStr Extracellular Vesicles as Potential Bladder Cancer Biomarkers: Take It or Leave It?
title_full_unstemmed Extracellular Vesicles as Potential Bladder Cancer Biomarkers: Take It or Leave It?
title_short Extracellular Vesicles as Potential Bladder Cancer Biomarkers: Take It or Leave It?
title_sort extracellular vesicles as potential bladder cancer biomarkers: take it or leave it?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094914/
https://www.ncbi.nlm.nih.gov/pubmed/37047731
http://dx.doi.org/10.3390/ijms24076757
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