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Short Interpregnancy Interval Following a Multifetal Pregnancy: Maternal and Neonatal Outcomes

Objective: To evaluate the maternal and neonatal outcomes of women with short interpregnancy intervals (IPI < 6 months) following a multifetal pregnancy. Study design: A multicenter retrospective cohort study of women with an index multifetal delivery and a subsequent singleton gestation between...

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Autores principales: Weiss, Ari, Sela, Hen Y., Grisaru-Granovsky, Sorina, Rottenstreich, Misgav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094927/
https://www.ncbi.nlm.nih.gov/pubmed/37048660
http://dx.doi.org/10.3390/jcm12072576
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author Weiss, Ari
Sela, Hen Y.
Grisaru-Granovsky, Sorina
Rottenstreich, Misgav
author_facet Weiss, Ari
Sela, Hen Y.
Grisaru-Granovsky, Sorina
Rottenstreich, Misgav
author_sort Weiss, Ari
collection PubMed
description Objective: To evaluate the maternal and neonatal outcomes of women with short interpregnancy intervals (IPI < 6 months) following a multifetal pregnancy. Study design: A multicenter retrospective cohort study of women with an index multifetal delivery and a subsequent singleton gestation between 2005 and 2021. The obstetrical outcomes of pregnancies following short IPI (<6 months) were compared to those with an IPI of 18–48 months. Additional analyses were also conducted for the other IPI groups: 7–17 months, and longer than 49 months, while women with an IPI of 18–48 months served as the reference group. The primary outcome was preterm birth (<37 weeks) rate. Secondary outcomes were other adverse maternal and neonatal outcomes. Univariate and multiple logistic regression analyses were performed. Results: Overall, 2514 women had a primary multifetal delivery with a subsequent singleton gestation at our medical centers; 160 (6.4%) had a short IPI, and 1142 (45.4%) had an optimal IPI. Women with a singleton gestation following a short IPI were younger, with lower rates of previous cesarean and fertility treatments. Women in the short IPI group had significantly higher rates of preterm birth <37 weeks, anemia (Hb < 11 gr%) on admission to the delivery room, and placental abruption. Multivariable logistic regression analysis demonstrated that short IPI is associated with an increased risk for preterm birth (aOR 2.39, 95% CI 1.12–5.11, p = 0.03). Conclusion: Short IPI following a multifetal gestation is associated with an increased risk for preterm birth in subsequent singleton pregnancy.
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spelling pubmed-100949272023-04-13 Short Interpregnancy Interval Following a Multifetal Pregnancy: Maternal and Neonatal Outcomes Weiss, Ari Sela, Hen Y. Grisaru-Granovsky, Sorina Rottenstreich, Misgav J Clin Med Article Objective: To evaluate the maternal and neonatal outcomes of women with short interpregnancy intervals (IPI < 6 months) following a multifetal pregnancy. Study design: A multicenter retrospective cohort study of women with an index multifetal delivery and a subsequent singleton gestation between 2005 and 2021. The obstetrical outcomes of pregnancies following short IPI (<6 months) were compared to those with an IPI of 18–48 months. Additional analyses were also conducted for the other IPI groups: 7–17 months, and longer than 49 months, while women with an IPI of 18–48 months served as the reference group. The primary outcome was preterm birth (<37 weeks) rate. Secondary outcomes were other adverse maternal and neonatal outcomes. Univariate and multiple logistic regression analyses were performed. Results: Overall, 2514 women had a primary multifetal delivery with a subsequent singleton gestation at our medical centers; 160 (6.4%) had a short IPI, and 1142 (45.4%) had an optimal IPI. Women with a singleton gestation following a short IPI were younger, with lower rates of previous cesarean and fertility treatments. Women in the short IPI group had significantly higher rates of preterm birth <37 weeks, anemia (Hb < 11 gr%) on admission to the delivery room, and placental abruption. Multivariable logistic regression analysis demonstrated that short IPI is associated with an increased risk for preterm birth (aOR 2.39, 95% CI 1.12–5.11, p = 0.03). Conclusion: Short IPI following a multifetal gestation is associated with an increased risk for preterm birth in subsequent singleton pregnancy. MDPI 2023-03-29 /pmc/articles/PMC10094927/ /pubmed/37048660 http://dx.doi.org/10.3390/jcm12072576 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Weiss, Ari
Sela, Hen Y.
Grisaru-Granovsky, Sorina
Rottenstreich, Misgav
Short Interpregnancy Interval Following a Multifetal Pregnancy: Maternal and Neonatal Outcomes
title Short Interpregnancy Interval Following a Multifetal Pregnancy: Maternal and Neonatal Outcomes
title_full Short Interpregnancy Interval Following a Multifetal Pregnancy: Maternal and Neonatal Outcomes
title_fullStr Short Interpregnancy Interval Following a Multifetal Pregnancy: Maternal and Neonatal Outcomes
title_full_unstemmed Short Interpregnancy Interval Following a Multifetal Pregnancy: Maternal and Neonatal Outcomes
title_short Short Interpregnancy Interval Following a Multifetal Pregnancy: Maternal and Neonatal Outcomes
title_sort short interpregnancy interval following a multifetal pregnancy: maternal and neonatal outcomes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094927/
https://www.ncbi.nlm.nih.gov/pubmed/37048660
http://dx.doi.org/10.3390/jcm12072576
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