Cargando…

Screening for Diabetes Mellitus in Patients with Hidradenitis Suppurativa—A Monocentric Study in Germany

Hidradenitis suppurativa (HS) is a chronic skin disease that is often associated with metabolic disorders. Diabetes mellitus (DM) is a frequent comorbidity in HS. There is currently no established screening for DM in HS patients. The aim of our study was to identify high-risk groups of HS patients t...

Descripción completa

Detalles Bibliográficos
Autores principales: Abu Rached, Nessr, Gambichler, Thilo, Ocker, Lennart, Dietrich, Johannes W., Quast, Daniel R., Sieger, Christina, Seifert, Caroline, Scheel, Christina, Bechara, Falk G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094965/
https://www.ncbi.nlm.nih.gov/pubmed/37047569
http://dx.doi.org/10.3390/ijms24076596
_version_ 1785023967780667392
author Abu Rached, Nessr
Gambichler, Thilo
Ocker, Lennart
Dietrich, Johannes W.
Quast, Daniel R.
Sieger, Christina
Seifert, Caroline
Scheel, Christina
Bechara, Falk G.
author_facet Abu Rached, Nessr
Gambichler, Thilo
Ocker, Lennart
Dietrich, Johannes W.
Quast, Daniel R.
Sieger, Christina
Seifert, Caroline
Scheel, Christina
Bechara, Falk G.
author_sort Abu Rached, Nessr
collection PubMed
description Hidradenitis suppurativa (HS) is a chronic skin disease that is often associated with metabolic disorders. Diabetes mellitus (DM) is a frequent comorbidity in HS. There is currently no established screening for DM in HS patients. The aim of our study was to identify high-risk groups of HS patients that develop DM and to assess the frequency of different types of DM present in HS patients. To do so, we conducted a monocentric study in 99 patients with HS. All patients underwent detailed clinical and laboratory assessments, including the determination of glycated hemoglobin. Among the 20.2% of patients that presented with DM, type 2 was by far the most prevalent (19 out of 20 patients). Moreover, male gender, age, BMI, Hurley stage, modified Hidradenitis Suppurativa Score (mHSS), DLQI and hypertension all correlated with the glycated hemoglobin levels in the HS patients. In the multivariable analysis, Hurley stage III, older age, and higher BMI were significantly associated with DM. Specifically, patients at Hurley stage III were at a 5.3-fold increased risk of having DM type II compared to patients at earlier Hurley stages. Since many of the HS patients had not been diagnosed, our study reveals shortcomings in the screening for DM and suggest that this should be routinely performed in HS patients at high risk to avoid secondary complications.
format Online
Article
Text
id pubmed-10094965
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100949652023-04-13 Screening for Diabetes Mellitus in Patients with Hidradenitis Suppurativa—A Monocentric Study in Germany Abu Rached, Nessr Gambichler, Thilo Ocker, Lennart Dietrich, Johannes W. Quast, Daniel R. Sieger, Christina Seifert, Caroline Scheel, Christina Bechara, Falk G. Int J Mol Sci Article Hidradenitis suppurativa (HS) is a chronic skin disease that is often associated with metabolic disorders. Diabetes mellitus (DM) is a frequent comorbidity in HS. There is currently no established screening for DM in HS patients. The aim of our study was to identify high-risk groups of HS patients that develop DM and to assess the frequency of different types of DM present in HS patients. To do so, we conducted a monocentric study in 99 patients with HS. All patients underwent detailed clinical and laboratory assessments, including the determination of glycated hemoglobin. Among the 20.2% of patients that presented with DM, type 2 was by far the most prevalent (19 out of 20 patients). Moreover, male gender, age, BMI, Hurley stage, modified Hidradenitis Suppurativa Score (mHSS), DLQI and hypertension all correlated with the glycated hemoglobin levels in the HS patients. In the multivariable analysis, Hurley stage III, older age, and higher BMI were significantly associated with DM. Specifically, patients at Hurley stage III were at a 5.3-fold increased risk of having DM type II compared to patients at earlier Hurley stages. Since many of the HS patients had not been diagnosed, our study reveals shortcomings in the screening for DM and suggest that this should be routinely performed in HS patients at high risk to avoid secondary complications. MDPI 2023-04-01 /pmc/articles/PMC10094965/ /pubmed/37047569 http://dx.doi.org/10.3390/ijms24076596 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Abu Rached, Nessr
Gambichler, Thilo
Ocker, Lennart
Dietrich, Johannes W.
Quast, Daniel R.
Sieger, Christina
Seifert, Caroline
Scheel, Christina
Bechara, Falk G.
Screening for Diabetes Mellitus in Patients with Hidradenitis Suppurativa—A Monocentric Study in Germany
title Screening for Diabetes Mellitus in Patients with Hidradenitis Suppurativa—A Monocentric Study in Germany
title_full Screening for Diabetes Mellitus in Patients with Hidradenitis Suppurativa—A Monocentric Study in Germany
title_fullStr Screening for Diabetes Mellitus in Patients with Hidradenitis Suppurativa—A Monocentric Study in Germany
title_full_unstemmed Screening for Diabetes Mellitus in Patients with Hidradenitis Suppurativa—A Monocentric Study in Germany
title_short Screening for Diabetes Mellitus in Patients with Hidradenitis Suppurativa—A Monocentric Study in Germany
title_sort screening for diabetes mellitus in patients with hidradenitis suppurativa—a monocentric study in germany
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094965/
https://www.ncbi.nlm.nih.gov/pubmed/37047569
http://dx.doi.org/10.3390/ijms24076596
work_keys_str_mv AT aburachednessr screeningfordiabetesmellitusinpatientswithhidradenitissuppurativaamonocentricstudyingermany
AT gambichlerthilo screeningfordiabetesmellitusinpatientswithhidradenitissuppurativaamonocentricstudyingermany
AT ockerlennart screeningfordiabetesmellitusinpatientswithhidradenitissuppurativaamonocentricstudyingermany
AT dietrichjohannesw screeningfordiabetesmellitusinpatientswithhidradenitissuppurativaamonocentricstudyingermany
AT quastdanielr screeningfordiabetesmellitusinpatientswithhidradenitissuppurativaamonocentricstudyingermany
AT siegerchristina screeningfordiabetesmellitusinpatientswithhidradenitissuppurativaamonocentricstudyingermany
AT seifertcaroline screeningfordiabetesmellitusinpatientswithhidradenitissuppurativaamonocentricstudyingermany
AT scheelchristina screeningfordiabetesmellitusinpatientswithhidradenitissuppurativaamonocentricstudyingermany
AT becharafalkg screeningfordiabetesmellitusinpatientswithhidradenitissuppurativaamonocentricstudyingermany