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Molecular Investigation of the Fatal Bloodstream Candida orthopsilosis Infection Case following Gastrectomy

Candida orthopsilosis represents a closely related cryptic genospecies of Candida parapsilosis complex-misidentified in routine diagnostic assays. This is emerging in settings where central venous catheters, invasive medical interventions, and echinocandin treatments are most likely to be used. A 59...

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Autores principales: Mnichowska-Polanowska, Magdalena, Adamowicz, Magdalena, Wojciechowska-Koszko, Iwona, Kisiel, Anna, Wojciuk, Bartosz, Jarosz, Konrad, Dołęgowska, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094972/
https://www.ncbi.nlm.nih.gov/pubmed/37047514
http://dx.doi.org/10.3390/ijms24076541
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author Mnichowska-Polanowska, Magdalena
Adamowicz, Magdalena
Wojciechowska-Koszko, Iwona
Kisiel, Anna
Wojciuk, Bartosz
Jarosz, Konrad
Dołęgowska, Barbara
author_facet Mnichowska-Polanowska, Magdalena
Adamowicz, Magdalena
Wojciechowska-Koszko, Iwona
Kisiel, Anna
Wojciuk, Bartosz
Jarosz, Konrad
Dołęgowska, Barbara
author_sort Mnichowska-Polanowska, Magdalena
collection PubMed
description Candida orthopsilosis represents a closely related cryptic genospecies of Candida parapsilosis complex-misidentified in routine diagnostic assays. This is emerging in settings where central venous catheters, invasive medical interventions, and echinocandin treatments are most likely to be used. A 59-year-old, non-neutropenic male patient, was admitted to an intensive care unit (ICU) due to respiratory distress syndrome, following a partial gastrectomy. As a result of duodenal stump leakage, re-laparotomy was required, abdominal drains were provided and central line catheters were exchanged. Multiple isolates of Candida orthopsilosis drawn from consecutive blood cultures were identified, despite ongoing echinocandin therapy and confirmed in vitro echinocandins susceptibility of the isolated strain. Species identification was verified via ITS region sequencing. Herein, we report the well-documented—per clinical data and relevant laboratory diagnosis—first case of a bloodstream infection caused by Candida orthopsilosis in Poland.
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spelling pubmed-100949722023-04-13 Molecular Investigation of the Fatal Bloodstream Candida orthopsilosis Infection Case following Gastrectomy Mnichowska-Polanowska, Magdalena Adamowicz, Magdalena Wojciechowska-Koszko, Iwona Kisiel, Anna Wojciuk, Bartosz Jarosz, Konrad Dołęgowska, Barbara Int J Mol Sci Case Report Candida orthopsilosis represents a closely related cryptic genospecies of Candida parapsilosis complex-misidentified in routine diagnostic assays. This is emerging in settings where central venous catheters, invasive medical interventions, and echinocandin treatments are most likely to be used. A 59-year-old, non-neutropenic male patient, was admitted to an intensive care unit (ICU) due to respiratory distress syndrome, following a partial gastrectomy. As a result of duodenal stump leakage, re-laparotomy was required, abdominal drains were provided and central line catheters were exchanged. Multiple isolates of Candida orthopsilosis drawn from consecutive blood cultures were identified, despite ongoing echinocandin therapy and confirmed in vitro echinocandins susceptibility of the isolated strain. Species identification was verified via ITS region sequencing. Herein, we report the well-documented—per clinical data and relevant laboratory diagnosis—first case of a bloodstream infection caused by Candida orthopsilosis in Poland. MDPI 2023-03-31 /pmc/articles/PMC10094972/ /pubmed/37047514 http://dx.doi.org/10.3390/ijms24076541 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Mnichowska-Polanowska, Magdalena
Adamowicz, Magdalena
Wojciechowska-Koszko, Iwona
Kisiel, Anna
Wojciuk, Bartosz
Jarosz, Konrad
Dołęgowska, Barbara
Molecular Investigation of the Fatal Bloodstream Candida orthopsilosis Infection Case following Gastrectomy
title Molecular Investigation of the Fatal Bloodstream Candida orthopsilosis Infection Case following Gastrectomy
title_full Molecular Investigation of the Fatal Bloodstream Candida orthopsilosis Infection Case following Gastrectomy
title_fullStr Molecular Investigation of the Fatal Bloodstream Candida orthopsilosis Infection Case following Gastrectomy
title_full_unstemmed Molecular Investigation of the Fatal Bloodstream Candida orthopsilosis Infection Case following Gastrectomy
title_short Molecular Investigation of the Fatal Bloodstream Candida orthopsilosis Infection Case following Gastrectomy
title_sort molecular investigation of the fatal bloodstream candida orthopsilosis infection case following gastrectomy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094972/
https://www.ncbi.nlm.nih.gov/pubmed/37047514
http://dx.doi.org/10.3390/ijms24076541
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