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Molecular Investigation of the Fatal Bloodstream Candida orthopsilosis Infection Case following Gastrectomy
Candida orthopsilosis represents a closely related cryptic genospecies of Candida parapsilosis complex-misidentified in routine diagnostic assays. This is emerging in settings where central venous catheters, invasive medical interventions, and echinocandin treatments are most likely to be used. A 59...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094972/ https://www.ncbi.nlm.nih.gov/pubmed/37047514 http://dx.doi.org/10.3390/ijms24076541 |
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author | Mnichowska-Polanowska, Magdalena Adamowicz, Magdalena Wojciechowska-Koszko, Iwona Kisiel, Anna Wojciuk, Bartosz Jarosz, Konrad Dołęgowska, Barbara |
author_facet | Mnichowska-Polanowska, Magdalena Adamowicz, Magdalena Wojciechowska-Koszko, Iwona Kisiel, Anna Wojciuk, Bartosz Jarosz, Konrad Dołęgowska, Barbara |
author_sort | Mnichowska-Polanowska, Magdalena |
collection | PubMed |
description | Candida orthopsilosis represents a closely related cryptic genospecies of Candida parapsilosis complex-misidentified in routine diagnostic assays. This is emerging in settings where central venous catheters, invasive medical interventions, and echinocandin treatments are most likely to be used. A 59-year-old, non-neutropenic male patient, was admitted to an intensive care unit (ICU) due to respiratory distress syndrome, following a partial gastrectomy. As a result of duodenal stump leakage, re-laparotomy was required, abdominal drains were provided and central line catheters were exchanged. Multiple isolates of Candida orthopsilosis drawn from consecutive blood cultures were identified, despite ongoing echinocandin therapy and confirmed in vitro echinocandins susceptibility of the isolated strain. Species identification was verified via ITS region sequencing. Herein, we report the well-documented—per clinical data and relevant laboratory diagnosis—first case of a bloodstream infection caused by Candida orthopsilosis in Poland. |
format | Online Article Text |
id | pubmed-10094972 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100949722023-04-13 Molecular Investigation of the Fatal Bloodstream Candida orthopsilosis Infection Case following Gastrectomy Mnichowska-Polanowska, Magdalena Adamowicz, Magdalena Wojciechowska-Koszko, Iwona Kisiel, Anna Wojciuk, Bartosz Jarosz, Konrad Dołęgowska, Barbara Int J Mol Sci Case Report Candida orthopsilosis represents a closely related cryptic genospecies of Candida parapsilosis complex-misidentified in routine diagnostic assays. This is emerging in settings where central venous catheters, invasive medical interventions, and echinocandin treatments are most likely to be used. A 59-year-old, non-neutropenic male patient, was admitted to an intensive care unit (ICU) due to respiratory distress syndrome, following a partial gastrectomy. As a result of duodenal stump leakage, re-laparotomy was required, abdominal drains were provided and central line catheters were exchanged. Multiple isolates of Candida orthopsilosis drawn from consecutive blood cultures were identified, despite ongoing echinocandin therapy and confirmed in vitro echinocandins susceptibility of the isolated strain. Species identification was verified via ITS region sequencing. Herein, we report the well-documented—per clinical data and relevant laboratory diagnosis—first case of a bloodstream infection caused by Candida orthopsilosis in Poland. MDPI 2023-03-31 /pmc/articles/PMC10094972/ /pubmed/37047514 http://dx.doi.org/10.3390/ijms24076541 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Mnichowska-Polanowska, Magdalena Adamowicz, Magdalena Wojciechowska-Koszko, Iwona Kisiel, Anna Wojciuk, Bartosz Jarosz, Konrad Dołęgowska, Barbara Molecular Investigation of the Fatal Bloodstream Candida orthopsilosis Infection Case following Gastrectomy |
title | Molecular Investigation of the Fatal Bloodstream Candida orthopsilosis Infection Case following Gastrectomy |
title_full | Molecular Investigation of the Fatal Bloodstream Candida orthopsilosis Infection Case following Gastrectomy |
title_fullStr | Molecular Investigation of the Fatal Bloodstream Candida orthopsilosis Infection Case following Gastrectomy |
title_full_unstemmed | Molecular Investigation of the Fatal Bloodstream Candida orthopsilosis Infection Case following Gastrectomy |
title_short | Molecular Investigation of the Fatal Bloodstream Candida orthopsilosis Infection Case following Gastrectomy |
title_sort | molecular investigation of the fatal bloodstream candida orthopsilosis infection case following gastrectomy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094972/ https://www.ncbi.nlm.nih.gov/pubmed/37047514 http://dx.doi.org/10.3390/ijms24076541 |
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